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Acute Nonlymphocytic Leukemia and Acute Aplastic Anemia: The Simultaneous Occurrence in Marital Partners

Acute Nonlymphocytic Leukemia and Acute Aplastic Anemia: The Simultaneous Occurrence in Marital... Abstract • A young husband and wife couple presented simultaneously with aplastic anemia and acute myelomonocytic leukemia, respectively. No etiologic agent or exposure was identified. With appropriate therapy, the wife achieved a complete remission and the husband has had a good response. Potential etiologic environmental factors known to cause both disorders are discussed. A single causative agent may induce stem-cell changes in genetically dissimilar persons and produce a spectrum of pathologic features ranging from aplastic anemia to acute leukemia. (Arch Intern Med 1983;143:1156-1158) References 1. Quesenberry P, Levitt L: Hematopoietic stem cells. N Engl J Med 1979;301:755-760, 819-823, 868-872.Crossref 2. Williams DM, Lynch RE, Cartwright GE: Drug-induced aplastic anemia. Semin Hematol 1973;10:195-223. 3. Aksoy M, Erdem S: Follow-up study on the mortality and the development of leukemia in 44 pancytopenic patients with chronic exposure to benzene. Blood 1978;52:285-292. 4. Alter BP, Potter NU, Li FP: Classification and aetiology of the aplastic anemias , in Thomas ED (ed): Clinics in Hematology . Philadelphia, WB Saunders Co, 1978, vol 7, pp 431-465. 5. Wintrobe MM, Lee GR, Boggs DR: Clinical Hematology , ed 8. Philadelphia, Lea & Febiger, 1981, p 1457. 6. Cohen T, Creger WP: Acute myeloid leukemia following seven years of aplastic anemia induced by chloramphenicol. Am J Med 1967;43:762-770.Crossref 7. Jensen MK, Roll K: Phenylbutazone and leukemia. Acta Med Scand 1965;178:505-513.Crossref 8. Brown WMC, Doll R: Mortality from cancer and other causes after radiotherapy for ankylosing spondylitis. Br Med J 1965;2:1327-1332.Crossref 9. Lewis EB: Leukemia, multiple myeloma, and aplastic anemia in American radiologists. Science 1963;142:1492-1494.Crossref 10. Kirshbaum JD, Matsuo T, Sato K, et al: A study of aplastic anemia in an autopsy series with special reference to atomic bomb survivors in Hiroshima and Nagasaki. Blood 1971;38:17-26. 11. The Committee for the Compilation of Materials on Damage Caused by the Atomic Bombs in Hiroshima and Nagasaki: Hiroshima and Nagasaki: The Physical, Medical, and Social Effects of the Atomic Bombings . New York, Basic Books, 1981. 12. Gutensohn N, Essex M, Francis DP, et al: Risk to humans from exposure to feline leukemia virus: Epidemiological considerations , in Essex M, Todaro G, zurHausen H (eds): Viruses in naturally occurring cancers. Cold Spring Harbor Symp Quant Biol 1980;7:699-706. 13. Mackey L, Jarrett W, Jarrett O, et al: Anemia associated with feline leukemia virus infection in cats. JNCI 1975;54:209-217. 14. Camitta BM: The role of viral infections in aplastic anemia. Hematol Blood Trans 1979;24:39-46. 15. Gross L: The search for viruses as etiological agents in leukemia and malignant lymphomas: The role of the happy accident and the prepared mind. Cancer Res 1980;40:3405-3407. 16. Hagler L, Pastone RA, Bergin JJ: Aplastic anemia following viral hepatitis: Report of two fatal cases and literature review. Medicine 1975; 54:139-164.Crossref 17. Camitta BM, Nathan DG, Forman EN, et al: Posthepatitic severe aplastic anemia: An indication for early bone marrow transplantation. Blood 1974;43:473-483. 18. Purtilo DT, Sakamoto K, Barnabei V, et al: Epstein-Barr virus-induced diseases in boys with the X-linked lymphoproliferative syndrome. Am J Med 1982;73:49-56.Crossref 19. Klein G: The relationship of the virus to nasopharyngeal carcinoma , in Epstein MA, Achong BG (eds): The Epstein-Barr Virus . New York, Springer Publishing Co Inc, 1979, pp 339-350. 20. Hanto DW, Frizzera G, Gajl-Peczalska KG, et al: Epstein-Barr virus-induced B-cell lymphoma after renal transplantation. N Engl J Med 1982;306:913-918.Crossref 21. Robert-Guroff M, Nakao Y, Notake K, et al: Natural antibodies to human retrovirus HTLV in a cluster of Japanese patients with adult T-cell leukemia. Science 1982;215:975-978.Crossref 22. Alderson M: The epidemiology of leukemia. Adv Cancer Res 1980; 31:1-75. 23. Schimpff SC, Schimpff CR, Brager D, et al: Leukemia and lymphoma patients interlinked by prior social contact. Lancet 1975;1:124-129.Crossref 24. Schimpff SC, Brager DM, Schimpff CR, et al: Leukemia and lymphoma patients linked by prior social contact. Ann Intern Med 1976;84:547-550.Crossref 25. Timonen TTT, Ilvonen M: Contact with hospital, drugs, and chemicals as aetiological factors in leukemia. Lancet 1978;1:350-352.Crossref 26. Amos DA, Wellman WE, Bowie EJW, et al: Acute leukemia in a husband and wife. Mayo Clin Proc 1967;42:468-472. 27. Ly B, Stavem P, Saltvedt E: Acute myelogenous leukemia occurring at the same time in husband and wife. Scand J Haematol 1978;21:376-378.Crossref 28. Milham S Jr: Leukemia in husbands and wives. Science 1965;148: 98-100.Crossref 29. Camitta BM, Storb R, Thomas ED: Aplastic anemia. N Engl J Med 1982;306:645-652.Crossref 30. Morley A, Blake J: An animal model of chronic aplastic marrow failure: I. Late marrow failure after busulfan. Blood 1974;44:49-56. 31. Morley A, Trainor K, Blake J: A primary stem cell lesion in experimental chronic hypoplastic marrow failure. Blood 1975;45:681-688. 32. Haak HL: Experimental drug-induced aplastic anemia. Clin Haematol 1980;9:621-629. 33. Onions D, Jarrett O, Testa N, et al: Selective effect of feline leukaemia virus on early erythroid precursors. Nature 1982;296:156-158.Crossref 34. Fialkow PJ, Martin PJ, Najfeld V, et al: Evidence for a multistep pathogenesis of chronic myelogenous leukemia. Blood 1981;58:158-163. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Acute Nonlymphocytic Leukemia and Acute Aplastic Anemia: The Simultaneous Occurrence in Marital Partners

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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1983.00350060080013
Publisher site
See Article on Publisher Site

Abstract

Abstract • A young husband and wife couple presented simultaneously with aplastic anemia and acute myelomonocytic leukemia, respectively. No etiologic agent or exposure was identified. With appropriate therapy, the wife achieved a complete remission and the husband has had a good response. Potential etiologic environmental factors known to cause both disorders are discussed. A single causative agent may induce stem-cell changes in genetically dissimilar persons and produce a spectrum of pathologic features ranging from aplastic anemia to acute leukemia. (Arch Intern Med 1983;143:1156-1158) References 1. Quesenberry P, Levitt L: Hematopoietic stem cells. N Engl J Med 1979;301:755-760, 819-823, 868-872.Crossref 2. Williams DM, Lynch RE, Cartwright GE: Drug-induced aplastic anemia. Semin Hematol 1973;10:195-223. 3. Aksoy M, Erdem S: Follow-up study on the mortality and the development of leukemia in 44 pancytopenic patients with chronic exposure to benzene. Blood 1978;52:285-292. 4. Alter BP, Potter NU, Li FP: Classification and aetiology of the aplastic anemias , in Thomas ED (ed): Clinics in Hematology . Philadelphia, WB Saunders Co, 1978, vol 7, pp 431-465. 5. Wintrobe MM, Lee GR, Boggs DR: Clinical Hematology , ed 8. Philadelphia, Lea & Febiger, 1981, p 1457. 6. Cohen T, Creger WP: Acute myeloid leukemia following seven years of aplastic anemia induced by chloramphenicol. Am J Med 1967;43:762-770.Crossref 7. Jensen MK, Roll K: Phenylbutazone and leukemia. Acta Med Scand 1965;178:505-513.Crossref 8. Brown WMC, Doll R: Mortality from cancer and other causes after radiotherapy for ankylosing spondylitis. Br Med J 1965;2:1327-1332.Crossref 9. Lewis EB: Leukemia, multiple myeloma, and aplastic anemia in American radiologists. Science 1963;142:1492-1494.Crossref 10. Kirshbaum JD, Matsuo T, Sato K, et al: A study of aplastic anemia in an autopsy series with special reference to atomic bomb survivors in Hiroshima and Nagasaki. Blood 1971;38:17-26. 11. The Committee for the Compilation of Materials on Damage Caused by the Atomic Bombs in Hiroshima and Nagasaki: Hiroshima and Nagasaki: The Physical, Medical, and Social Effects of the Atomic Bombings . New York, Basic Books, 1981. 12. Gutensohn N, Essex M, Francis DP, et al: Risk to humans from exposure to feline leukemia virus: Epidemiological considerations , in Essex M, Todaro G, zurHausen H (eds): Viruses in naturally occurring cancers. Cold Spring Harbor Symp Quant Biol 1980;7:699-706. 13. Mackey L, Jarrett W, Jarrett O, et al: Anemia associated with feline leukemia virus infection in cats. JNCI 1975;54:209-217. 14. Camitta BM: The role of viral infections in aplastic anemia. Hematol Blood Trans 1979;24:39-46. 15. Gross L: The search for viruses as etiological agents in leukemia and malignant lymphomas: The role of the happy accident and the prepared mind. Cancer Res 1980;40:3405-3407. 16. Hagler L, Pastone RA, Bergin JJ: Aplastic anemia following viral hepatitis: Report of two fatal cases and literature review. Medicine 1975; 54:139-164.Crossref 17. Camitta BM, Nathan DG, Forman EN, et al: Posthepatitic severe aplastic anemia: An indication for early bone marrow transplantation. Blood 1974;43:473-483. 18. Purtilo DT, Sakamoto K, Barnabei V, et al: Epstein-Barr virus-induced diseases in boys with the X-linked lymphoproliferative syndrome. Am J Med 1982;73:49-56.Crossref 19. Klein G: The relationship of the virus to nasopharyngeal carcinoma , in Epstein MA, Achong BG (eds): The Epstein-Barr Virus . New York, Springer Publishing Co Inc, 1979, pp 339-350. 20. Hanto DW, Frizzera G, Gajl-Peczalska KG, et al: Epstein-Barr virus-induced B-cell lymphoma after renal transplantation. N Engl J Med 1982;306:913-918.Crossref 21. Robert-Guroff M, Nakao Y, Notake K, et al: Natural antibodies to human retrovirus HTLV in a cluster of Japanese patients with adult T-cell leukemia. Science 1982;215:975-978.Crossref 22. Alderson M: The epidemiology of leukemia. Adv Cancer Res 1980; 31:1-75. 23. Schimpff SC, Schimpff CR, Brager D, et al: Leukemia and lymphoma patients interlinked by prior social contact. Lancet 1975;1:124-129.Crossref 24. Schimpff SC, Brager DM, Schimpff CR, et al: Leukemia and lymphoma patients linked by prior social contact. Ann Intern Med 1976;84:547-550.Crossref 25. Timonen TTT, Ilvonen M: Contact with hospital, drugs, and chemicals as aetiological factors in leukemia. Lancet 1978;1:350-352.Crossref 26. Amos DA, Wellman WE, Bowie EJW, et al: Acute leukemia in a husband and wife. Mayo Clin Proc 1967;42:468-472. 27. Ly B, Stavem P, Saltvedt E: Acute myelogenous leukemia occurring at the same time in husband and wife. Scand J Haematol 1978;21:376-378.Crossref 28. Milham S Jr: Leukemia in husbands and wives. Science 1965;148: 98-100.Crossref 29. Camitta BM, Storb R, Thomas ED: Aplastic anemia. N Engl J Med 1982;306:645-652.Crossref 30. Morley A, Blake J: An animal model of chronic aplastic marrow failure: I. Late marrow failure after busulfan. Blood 1974;44:49-56. 31. Morley A, Trainor K, Blake J: A primary stem cell lesion in experimental chronic hypoplastic marrow failure. Blood 1975;45:681-688. 32. Haak HL: Experimental drug-induced aplastic anemia. Clin Haematol 1980;9:621-629. 33. Onions D, Jarrett O, Testa N, et al: Selective effect of feline leukaemia virus on early erythroid precursors. Nature 1982;296:156-158.Crossref 34. Fialkow PJ, Martin PJ, Najfeld V, et al: Evidence for a multistep pathogenesis of chronic myelogenous leukemia. Blood 1981;58:158-163.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jun 1, 1983

References