Abstract
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To the Editor:— The article by Leroy and Snider (The Journal, Dec. 13, 1941, p. 2019) offers convincing experimental proof that ventricular fibrillation is frequently the cause of sudden unexpected death in dogs with coronary thrombosis and myocardial infarction. However, I feel it is not entirely just to develop the therapeutic regimen they have suggested for the treatment of acute myocardial infarction in man. Some patients with myocardial infarction die of cardiac standstill rather than ventricular fibrillation (Grieco, E. H., and Schwartz, S. P.: Am. Heart J. 16:595 [Nov.] 1938). There are a number of additional reasons why I think the routine intravenous administration of theophylline with ethylene diamine (aminophylline) and atropine is inadvisable. The value of theophylline with ethylene diamine or the other so-called coronary vasodilators in the treatment of coronary artery disease is still a very debatable topic. Furthermore, ventricular fibrillation may occur on the fourteenth day
JAMA – American Medical Association
Published: Jan 17, 1942
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