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Acute Leukemia After Radioactive Iodine (I131) Therapy for Hyperthyroidism

Acute Leukemia After Radioactive Iodine (I131) Therapy for Hyperthyroidism Abstract During the 13 years since radioactive iodine, I131, became available, there has been little direct evidence to cast doubt on its safety. Attention has been focused largely on the possibility that radioactive iodine therapy for hyperthyroidism would lead to a higher incidence of cancer of the thyroid.1,2 This concern is based on the obvious fact that thyroid tissue is by far the most heavily irradiated after radioactive iodine administration, by the observation that there is an increased incidence of carcinoma of the thyroid in children treated with x-ray therapy of the thymus,3,4 and by animal experiments in which carcinoma of the thyroid was produced by irradiation.5 Recently, the occurrence of adenomata in three patients who had received radioactive iodine therapy for hyperthyroidism before the age of 20 has been reported.6 In one of these, the pathological findings were interpreted as "low-grade follicular carcinoma." The possibility that radioactive iodine may be References 1. Duffy, B. J., Jr.: Can Radiation Cause Thyroid Cancer? Editorial Review , J. Clin. Endocrinol. 17:1383, 1957.Crossref 2. Ochsner, A.: Is the Treatment of Benign Thyroid Disease with Radioactive Iodine Without Danger? Editorial , Surgery 40:1128, 1956. 3. Clark, D. E.: Association of Irradiation with Cancer of the Thyroid in Children and Adolescents , J.A.M.A. 159:1007, 1955.Crossref 4. Simpson, C. L.; Hempelmann, L. H., and Fuller, L. M.: Neoplasia in Children Treated with X-Rays in Infancy for Thymic Enlargement , Radiology 64:840, 1955.Crossref 5. Doniach, I.: The Effect of Radioactive Iodine Alone and in Combination with Methylthiouracil Upon Tumour Production in the Rat's Thyroid Gland , Brit. J. Cancer 7:181, 1953.Crossref 6. Sheline, G. E.; Lindsay, S., and Bell, H. G.: Occurrence of Thyroid Nodules in Children Following Therapy with Radioiodine for Hyperthyroidism , J. Clin. Endocrinol. 19:127, 1959.Crossref 7. Pochin, E. E.; Myant, N. B., and Corbett, B. D.: Leukaemia Following Radioiodine Treatment of Hyperthyroidism , Brit. J. Radiol. 29:31, 1956.Crossref 8. Abbatt, J. D.; Farran, H. E. A., and Greene, R.: Acute Myeloid-Leukaemia After Radioactive-Iodine Therapy , Lancet 1:782, 1956.Crossref 9. Werner, S. C., and Ouimby, E. H.: Acute Leukemia After Radioactive Iodine (I131) Therapy for Hyperthyroidism , J.A.M.A. 165:1558, 1957.Crossref 10. Kennedy, W. M., and Fish, R. G.: Acute Granulocytic Leukemia After Radioactive Iodine Therapy for Hyperthyroidism , New England J. Med. 260:76, 1959.Crossref 11. Werner, S., in Proceedings of the Conference on Radio-Iodine, Nov. 5 and 6, 1956, Chicago, Ill. Sponsored by the Argonne Cancer Research Hospital, U.S. Atomic Energy Commission, and the Clinics of the University of Chicago, p. 33. 12. Childs, D., in Proceedings of the Conference on Radio-Iodine, Nov. 5 and 6, 1956, Chicago, Ill. Sponsored by the Argonne Cancer Research Hospital, U.S. Atomic Energy Commission, and the Clinics of the University of Chicago, p. 33. 13. Blomfield, G. W.; Eckert, H.; Fisher, M.; Miller, H.; Munro, D. S., and Wilson, G. M.: Treatment of Thyrotoxicosis with I131: A Review of 500 Cases , Brit. M.J. 1:63, 1959.Crossref 14. Vetter, H., and Hofer, R.: Acute Leukaemia Following Radioiodine Therapy of Thyrotoxicosis , Brit. J. Radiol. 32:263, 1959.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Acute Leukemia After Radioactive Iodine (I131) Therapy for Hyperthyroidism

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Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1960.03820010099014
Publisher site
See Article on Publisher Site

Abstract

Abstract During the 13 years since radioactive iodine, I131, became available, there has been little direct evidence to cast doubt on its safety. Attention has been focused largely on the possibility that radioactive iodine therapy for hyperthyroidism would lead to a higher incidence of cancer of the thyroid.1,2 This concern is based on the obvious fact that thyroid tissue is by far the most heavily irradiated after radioactive iodine administration, by the observation that there is an increased incidence of carcinoma of the thyroid in children treated with x-ray therapy of the thymus,3,4 and by animal experiments in which carcinoma of the thyroid was produced by irradiation.5 Recently, the occurrence of adenomata in three patients who had received radioactive iodine therapy for hyperthyroidism before the age of 20 has been reported.6 In one of these, the pathological findings were interpreted as "low-grade follicular carcinoma." The possibility that radioactive iodine may be References 1. Duffy, B. J., Jr.: Can Radiation Cause Thyroid Cancer? Editorial Review , J. Clin. Endocrinol. 17:1383, 1957.Crossref 2. Ochsner, A.: Is the Treatment of Benign Thyroid Disease with Radioactive Iodine Without Danger? Editorial , Surgery 40:1128, 1956. 3. Clark, D. E.: Association of Irradiation with Cancer of the Thyroid in Children and Adolescents , J.A.M.A. 159:1007, 1955.Crossref 4. Simpson, C. L.; Hempelmann, L. H., and Fuller, L. M.: Neoplasia in Children Treated with X-Rays in Infancy for Thymic Enlargement , Radiology 64:840, 1955.Crossref 5. Doniach, I.: The Effect of Radioactive Iodine Alone and in Combination with Methylthiouracil Upon Tumour Production in the Rat's Thyroid Gland , Brit. J. Cancer 7:181, 1953.Crossref 6. Sheline, G. E.; Lindsay, S., and Bell, H. G.: Occurrence of Thyroid Nodules in Children Following Therapy with Radioiodine for Hyperthyroidism , J. Clin. Endocrinol. 19:127, 1959.Crossref 7. Pochin, E. E.; Myant, N. B., and Corbett, B. D.: Leukaemia Following Radioiodine Treatment of Hyperthyroidism , Brit. J. Radiol. 29:31, 1956.Crossref 8. Abbatt, J. D.; Farran, H. E. A., and Greene, R.: Acute Myeloid-Leukaemia After Radioactive-Iodine Therapy , Lancet 1:782, 1956.Crossref 9. Werner, S. C., and Ouimby, E. H.: Acute Leukemia After Radioactive Iodine (I131) Therapy for Hyperthyroidism , J.A.M.A. 165:1558, 1957.Crossref 10. Kennedy, W. M., and Fish, R. G.: Acute Granulocytic Leukemia After Radioactive Iodine Therapy for Hyperthyroidism , New England J. Med. 260:76, 1959.Crossref 11. Werner, S., in Proceedings of the Conference on Radio-Iodine, Nov. 5 and 6, 1956, Chicago, Ill. Sponsored by the Argonne Cancer Research Hospital, U.S. Atomic Energy Commission, and the Clinics of the University of Chicago, p. 33. 12. Childs, D., in Proceedings of the Conference on Radio-Iodine, Nov. 5 and 6, 1956, Chicago, Ill. Sponsored by the Argonne Cancer Research Hospital, U.S. Atomic Energy Commission, and the Clinics of the University of Chicago, p. 33. 13. Blomfield, G. W.; Eckert, H.; Fisher, M.; Miller, H.; Munro, D. S., and Wilson, G. M.: Treatment of Thyrotoxicosis with I131: A Review of 500 Cases , Brit. M.J. 1:63, 1959.Crossref 14. Vetter, H., and Hofer, R.: Acute Leukaemia Following Radioiodine Therapy of Thyrotoxicosis , Brit. J. Radiol. 32:263, 1959.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jul 1, 1960

References