Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Acute Iron Intoxication: Treatment With Desferrioxamine (Ba-29837)

Acute Iron Intoxication: Treatment With Desferrioxamine (Ba-29837) Abstract Many physicians are not aware of the seriousness of poisoning with the ferrous and ferric salts of iron. At the turn of the century, before iron therapy became widespread, there were few reports of iron intoxication. However, with the increased clinical use of iron, there has been an alarming increase in the incidence of iron toxicity. One of the first of these was the report by Forbes, in 1947,1 of two fatal cases of ferrous sulfate poisoning in children. In Great Britain, iron is considered the most important single cause of poisoning in children.2 Cumulative experience discloses close to 50% mortality in dosage ranges from 2 to 4 gm of orally ingested iron 3 in children. Because of the high mortality rate associated with iron toxicity, a more effective form of treatment is required. A number of approaches have been directed toward chelation of free iron in order References 1. Forbes, G.: Poisoning With Preparation of Iron, Copper and Manganese , Brit Med J 1:367, 1947.Crossref 2. Accidental Iron Poisoning in Children, Committee on Toxicology , JAMA 170:676, 1959.Crossref 3. Ross, F. G. H.: Pyloric Stenosis and Fibrous Stricture of Stomach Due to Ferrous Sulfate Poisoning , Brit Med J 2:1200, 1953.Crossref 4. Simpson, K., and Blunt, A.: Acute Ferrous Sulfate Poisoning Treated With Edathamil Calcium Disodium , Lancet 2:1120, 1960.Crossref 5. Barrie, H., and Wilson, B.D.R.: Calcium Disodium Edathamil in Treatment of Ferrous Sulfate Poisoning , JAMA 180:244, 1962.Crossref 6. Shoss, J.: Ferrous Sulfate Poisoning: A Case Treated With BAL , J Pediat 44:77, 1954.Crossref 7. Amerman, E. E.; Brescia, M. A.; and Aftahi, F.: Ferrous Sulfate Poisoning: Report of a Case Successfully Treated by Exchange Transfusion , J Pediat 53:476, 1958.Crossref 8. Moeschlin, S., and Schnider, U.: Treatment of Primary and Secondary Hemochromatosis and Acute Iron Poisoning With New, Potent Iron-Eliminating Agent (Desferrioxamine-B) , New Eng J Med 269:57, 1963.Crossref 9. Bannerman, R. M.; Callender, S. T.; and Williams, D. L.: Effect of Desferrioxamine and D.T.P.A. in Iron Overload , Brit Med J 2:1573, 1962.Crossref 10. Foucar, F. H.; Gordon, E. S.; and Kaye, S.: Death Following Ingestion of Ferrous Sulfate , Amer J Clin Path 18:971, 1948. 11. Bromson, W. R., and Sisson, T. R. C.: Studies on Acute Iron Poisoning , AMA J Dis Child 99:18, 1960. 12. Brown, R. J. K., and Gray, J. D.: The Mechanism of Acute Ferrous Sulfate Poisoning , Canad Med Ass J 73:192, 1955. 13. Prain, J. H.: Fatal Poisoning of Infant by Anti-Anaemic Pills Containing Iron, Manganese and Copper , Brit Med J 2:1019, 1949.Crossref 14. Luongo, M. A., and Bjornson, S. S.: The Liver in Ferrous Sulfate Poisoning: Report of Three Fatal Cases in Children and Experimental Study , New Eng J Med 251:995, 1954.Crossref 15. Annotation on "Iron as a Liver Poison," Lancet 1:552, 1955. 16. Smith, J. P.: The Pathology of Ferrous Sulfate Poisoning , J Path Bact 64:467, 1952.Crossref 17. Mazur, A., and Shorr, E.: Hepatorenal Factors in Circulating Homeostasis: IX. The Identification of the Hepatic Vasodepressor Substance, VDM, With Ferritin , J Biol Chem 176:771, 1948. 18. Reissmann, K. R., and Coleman, T. J.: Acute Intestinal Iron Intoxication: II. Metabolic, Respiratory and Circulating Effects of Absorbed Iron Salts , Blood 10:46, 1955. 19. Awai, M.: Pathophysiological Studies on Ferric Iron: 2. Quantitative Observations on Reaction Between Ferric Iron and Serum Protein , Acta Med Okayama 12:320, 1958. 20. Awai, M.: Pathophysiological Studies on Ferric Iron: 4. Biological Observations of Serum Colloid , Acta Med Okayama 12:336, 1958. 21. Imhof, P.: "Experience to Date With Desferrioxamine in the Treatment of Diseases Involving a Pathological Deposition of Iron in the Organism," in Proceedings of the Meeting of Clinical Investigators, CIBA, Basel, Switzerland, Nov 16, 1961. 22. Imhof, P.: "Results With Desferrioxamine in Pathological Deposition," in Proceedings of the Annual Meeting of the Swiss Hematology Society, CIBA, Lugano, Switzerland, May 18, 1962. 23. Sunderman, F. W., and Boerner, F.: Normal Values in Clinical Medicine , Philadelphia: W. B. Saunders Co., 1949, p 360. 24. Fahey, J. L., et al: Evaluation of Trisodium Calcium Diethylenetriaminepenta Acetate in Iron Storage Disease , J Lab Clin Med 57:436, 1961. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Acute Iron Intoxication: Treatment With Desferrioxamine (Ba-29837)

Loading next page...
 
/lp/american-medical-association/acute-iron-intoxication-treatment-with-desferrioxamine-ba-29837-LrGsDM7Ius

References (23)

Publisher
American Medical Association
Copyright
Copyright © 1964 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1964.02080060426016
Publisher site
See Article on Publisher Site

Abstract

Abstract Many physicians are not aware of the seriousness of poisoning with the ferrous and ferric salts of iron. At the turn of the century, before iron therapy became widespread, there were few reports of iron intoxication. However, with the increased clinical use of iron, there has been an alarming increase in the incidence of iron toxicity. One of the first of these was the report by Forbes, in 1947,1 of two fatal cases of ferrous sulfate poisoning in children. In Great Britain, iron is considered the most important single cause of poisoning in children.2 Cumulative experience discloses close to 50% mortality in dosage ranges from 2 to 4 gm of orally ingested iron 3 in children. Because of the high mortality rate associated with iron toxicity, a more effective form of treatment is required. A number of approaches have been directed toward chelation of free iron in order References 1. Forbes, G.: Poisoning With Preparation of Iron, Copper and Manganese , Brit Med J 1:367, 1947.Crossref 2. Accidental Iron Poisoning in Children, Committee on Toxicology , JAMA 170:676, 1959.Crossref 3. Ross, F. G. H.: Pyloric Stenosis and Fibrous Stricture of Stomach Due to Ferrous Sulfate Poisoning , Brit Med J 2:1200, 1953.Crossref 4. Simpson, K., and Blunt, A.: Acute Ferrous Sulfate Poisoning Treated With Edathamil Calcium Disodium , Lancet 2:1120, 1960.Crossref 5. Barrie, H., and Wilson, B.D.R.: Calcium Disodium Edathamil in Treatment of Ferrous Sulfate Poisoning , JAMA 180:244, 1962.Crossref 6. Shoss, J.: Ferrous Sulfate Poisoning: A Case Treated With BAL , J Pediat 44:77, 1954.Crossref 7. Amerman, E. E.; Brescia, M. A.; and Aftahi, F.: Ferrous Sulfate Poisoning: Report of a Case Successfully Treated by Exchange Transfusion , J Pediat 53:476, 1958.Crossref 8. Moeschlin, S., and Schnider, U.: Treatment of Primary and Secondary Hemochromatosis and Acute Iron Poisoning With New, Potent Iron-Eliminating Agent (Desferrioxamine-B) , New Eng J Med 269:57, 1963.Crossref 9. Bannerman, R. M.; Callender, S. T.; and Williams, D. L.: Effect of Desferrioxamine and D.T.P.A. in Iron Overload , Brit Med J 2:1573, 1962.Crossref 10. Foucar, F. H.; Gordon, E. S.; and Kaye, S.: Death Following Ingestion of Ferrous Sulfate , Amer J Clin Path 18:971, 1948. 11. Bromson, W. R., and Sisson, T. R. C.: Studies on Acute Iron Poisoning , AMA J Dis Child 99:18, 1960. 12. Brown, R. J. K., and Gray, J. D.: The Mechanism of Acute Ferrous Sulfate Poisoning , Canad Med Ass J 73:192, 1955. 13. Prain, J. H.: Fatal Poisoning of Infant by Anti-Anaemic Pills Containing Iron, Manganese and Copper , Brit Med J 2:1019, 1949.Crossref 14. Luongo, M. A., and Bjornson, S. S.: The Liver in Ferrous Sulfate Poisoning: Report of Three Fatal Cases in Children and Experimental Study , New Eng J Med 251:995, 1954.Crossref 15. Annotation on "Iron as a Liver Poison," Lancet 1:552, 1955. 16. Smith, J. P.: The Pathology of Ferrous Sulfate Poisoning , J Path Bact 64:467, 1952.Crossref 17. Mazur, A., and Shorr, E.: Hepatorenal Factors in Circulating Homeostasis: IX. The Identification of the Hepatic Vasodepressor Substance, VDM, With Ferritin , J Biol Chem 176:771, 1948. 18. Reissmann, K. R., and Coleman, T. J.: Acute Intestinal Iron Intoxication: II. Metabolic, Respiratory and Circulating Effects of Absorbed Iron Salts , Blood 10:46, 1955. 19. Awai, M.: Pathophysiological Studies on Ferric Iron: 2. Quantitative Observations on Reaction Between Ferric Iron and Serum Protein , Acta Med Okayama 12:320, 1958. 20. Awai, M.: Pathophysiological Studies on Ferric Iron: 4. Biological Observations of Serum Colloid , Acta Med Okayama 12:336, 1958. 21. Imhof, P.: "Experience to Date With Desferrioxamine in the Treatment of Diseases Involving a Pathological Deposition of Iron in the Organism," in Proceedings of the Meeting of Clinical Investigators, CIBA, Basel, Switzerland, Nov 16, 1961. 22. Imhof, P.: "Results With Desferrioxamine in Pathological Deposition," in Proceedings of the Annual Meeting of the Swiss Hematology Society, CIBA, Lugano, Switzerland, May 18, 1962. 23. Sunderman, F. W., and Boerner, F.: Normal Values in Clinical Medicine , Philadelphia: W. B. Saunders Co., 1949, p 360. 24. Fahey, J. L., et al: Evaluation of Trisodium Calcium Diethylenetriaminepenta Acetate in Iron Storage Disease , J Lab Clin Med 57:436, 1961.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Apr 1, 1964

There are no references for this article.