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ACUTE HEMOLYTIC ANEMIA ASSOCIATED WITH AUTOAGGLUTINATION WITH A THERMAL AMPLITUDE OF 0 TO 37 C.

ACUTE HEMOLYTIC ANEMIA ASSOCIATED WITH AUTOAGGLUTINATION WITH A THERMAL AMPLITUDE OF 0 TO 37 C. AUTOAGGLUTINATION is defined as the agglutination of a person's red cells by his own serum, because of the presence of an absorbable agglutinin in the serum and a corresponding agglutinogen in the cells (Wiener1). Although reports concerning clumping or sticking together of red cells, observed when counting red cells, go back as far as 1890 (Reitman,2 Klein,3 Ascoli4 and others), it is not certain whether these authors dealt with true autoagglutination or with pseudoagglutination (rouleaux formation). The first comprehensive description of true autoagglutination was given by Landsteiner5 (1903). He described the cold (auto) agglutinin as present in many normal serums, active at a temperature of 0 to 5 C. only and effective not only against the cells of the same person but also against each group of human erythrocytes and some groups of animal erythrocytes. The agglutination is reversible by warming and reappears in the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

ACUTE HEMOLYTIC ANEMIA ASSOCIATED WITH AUTOAGGLUTINATION WITH A THERMAL AMPLITUDE OF 0 TO 37 C.

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References (12)

Publisher
American Medical Association
Copyright
Copyright © 1946 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1946.02020320076009
Publisher site
See Article on Publisher Site

Abstract

AUTOAGGLUTINATION is defined as the agglutination of a person's red cells by his own serum, because of the presence of an absorbable agglutinin in the serum and a corresponding agglutinogen in the cells (Wiener1). Although reports concerning clumping or sticking together of red cells, observed when counting red cells, go back as far as 1890 (Reitman,2 Klein,3 Ascoli4 and others), it is not certain whether these authors dealt with true autoagglutination or with pseudoagglutination (rouleaux formation). The first comprehensive description of true autoagglutination was given by Landsteiner5 (1903). He described the cold (auto) agglutinin as present in many normal serums, active at a temperature of 0 to 5 C. only and effective not only against the cells of the same person but also against each group of human erythrocytes and some groups of animal erythrocytes. The agglutination is reversible by warming and reappears in the

Journal

American journal of diseases of childrenAmerican Medical Association

Published: Sep 1, 1946

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