Abstract Because of the rarity of Darier's disease (keratosis follicularis) occurring as an acute, eruptive disease in a mature adult, a case with sudden onset in a 51-year-old white man is reported. Small, pale-gray, smooth papules on the sides of the arms spread to the sides of the chest, abdomen, and legs within a week. With a biopsy examination, histopathologic findings were acanthosis, hyperkeratosis, lacunae, acantholysis, corps ronds, and grains. Topical therapy with 0.05% fluocinonide (Lidex) cream has given marked improvement. References 1. Andrews GC: Darier's disease , in Diseases of the Skin , ed 4. Philadelphia, WB Saunders Co, 1954, pp 605-607. 2. Sutton RL, Sutton RL Jr: Darier's disease , in Diseases of the Skin , ed 10. St Louis, CV Mosby Co, 1939, pp 592-597. 3. Ormsby OS, Montgomery H: Darier's disease , in Diseases of the Skin , ed 8. Philadelphia, Lea & Febiger Publishers, 1954, pp 583-589. 4. Montgomery H: Dermatopathology . New York, Paul B Hoeber, 1967, vol 1, pp 92-99. 5. Fernet P, Scheikevitch: Sur un cas d'érythrodermie ichthyosiforme non congenitale . Bull Soc Fr Dermatol Syphiligr , pp 87-90, 1919. 6. Witten VH, Gelfarb M: Keratosis follicularis of sudden inset . Arch Dermatol 87:733-735, 1963.
Archives of Dermatology – American Medical Association
Published: Feb 1, 1975
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