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Acute Anterior Descending Coronary Artery Ligation, Ventricular Fibrillation, and Ventricular Assistance: Survival Following These in the Miniature Pig

Acute Anterior Descending Coronary Artery Ligation, Ventricular Fibrillation, and Ventricular... Abstract Lumb1-4 has demonstrated that gradual occlusion of the coronary arteries in the pig allows nonfunctional collateral vessels to become functional in the ischemic myocardium. Lumb2 and Garamella5 demonstrated that acute occlusion of the left anterior descending coronary artery in the pig consistently produced ventricular fibrillation within 30 minutes. Our previous data6 confirmed this finding. Skinner7 demonstrated increased survival of dogs when acute occlusion of the left circumflex coronary artery was supported by mechanical ventricular assistance for five hours. Following acute occlusion of the left anterior descending coronary artery in the pig and ventricular fibrillation, we6 demonstrated that ventricular assistance for three hours allowed all hearts to be defibrillated with survival for 30 to 180 minutes. This experiment was devised to determine whether six hours of ventricular assistance with the Anstadt Ventricular Assistor8 would allow nonfunctioning coronary collaterals to become functional and increase survival References 1. Lumb, G.D., and Hardy, L.B.: Collateral Circulation and Survival Related to Gradual Occlusion of the Right Coronary Artery in the Pig , Circulation 27:717-721 ( (April) ) 1963.Crossref 2. Lumb, G., and Hardy, L.B.: Collaterals and Coronary Artery Narrowing: I. The Effect of Coronary Artery Narrowing on Collateral Channels in Swine , Lab Invest 13:1530-1540 ( (Dec) ) 1964. 3. Lumb, G., and Hardy, L.B.: Collateral Circulation in the Heart , N Carolina Med J 24:456-460 ( (Oct) ) 1963. 4. Lumb, G.; Singletary, H.P.; and Hardy, L.B.: Collateral Circulation Following Experimental Gradual Narrowing of the Coronary Arteries , Angiology 13:463-465 ( (Oct) ) 1962.Crossref 5. Garamella, J.J., et al: Antifibrillatory Agents and Surgery Tested by Closed Chest Coronary Occlusion in the Pig , Surgery 45:292-297 ( (Feb) ) 1959. 6. Hoffer, R.E., et al: Mechanical Ventricular Assistance for Circulatory Support in Acute Coronary Artery Occlusion in the Pig: The Anstadt Cup , Dis Chest 53:502-506 ( (April) ) 1968.Crossref 7. Skinner, D.B.; Anstadt, G.L.; and Camp, T.F., Jr.: Acute Circulatory Support by Mechanical Ventricular Assistance Following Myocardial Infarction , J Thorac Cardiovasc Surg 54:785-794 ( (Dec) ) 1967. 8. Anstadt, G.L.; Schiff, P.; and Baue, A.E.: Prolonged Circulatory Support by Direct Mechanical Ventricular Assistance , Trans Amer Soc Artif Intern Organs 12:72-79, 1966. 9. Lumb, G., and Hardy, L.B.: Technique for Dissection and Perfusion of Heart , Arch Path 77:233-238 ( (March) ) 1964. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Acute Anterior Descending Coronary Artery Ligation, Ventricular Fibrillation, and Ventricular Assistance: Survival Following These in the Miniature Pig

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References (9)

Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1969.01340120051005
Publisher site
See Article on Publisher Site

Abstract

Abstract Lumb1-4 has demonstrated that gradual occlusion of the coronary arteries in the pig allows nonfunctional collateral vessels to become functional in the ischemic myocardium. Lumb2 and Garamella5 demonstrated that acute occlusion of the left anterior descending coronary artery in the pig consistently produced ventricular fibrillation within 30 minutes. Our previous data6 confirmed this finding. Skinner7 demonstrated increased survival of dogs when acute occlusion of the left circumflex coronary artery was supported by mechanical ventricular assistance for five hours. Following acute occlusion of the left anterior descending coronary artery in the pig and ventricular fibrillation, we6 demonstrated that ventricular assistance for three hours allowed all hearts to be defibrillated with survival for 30 to 180 minutes. This experiment was devised to determine whether six hours of ventricular assistance with the Anstadt Ventricular Assistor8 would allow nonfunctioning coronary collaterals to become functional and increase survival References 1. Lumb, G.D., and Hardy, L.B.: Collateral Circulation and Survival Related to Gradual Occlusion of the Right Coronary Artery in the Pig , Circulation 27:717-721 ( (April) ) 1963.Crossref 2. Lumb, G., and Hardy, L.B.: Collaterals and Coronary Artery Narrowing: I. The Effect of Coronary Artery Narrowing on Collateral Channels in Swine , Lab Invest 13:1530-1540 ( (Dec) ) 1964. 3. Lumb, G., and Hardy, L.B.: Collateral Circulation in the Heart , N Carolina Med J 24:456-460 ( (Oct) ) 1963. 4. Lumb, G.; Singletary, H.P.; and Hardy, L.B.: Collateral Circulation Following Experimental Gradual Narrowing of the Coronary Arteries , Angiology 13:463-465 ( (Oct) ) 1962.Crossref 5. Garamella, J.J., et al: Antifibrillatory Agents and Surgery Tested by Closed Chest Coronary Occlusion in the Pig , Surgery 45:292-297 ( (Feb) ) 1959. 6. Hoffer, R.E., et al: Mechanical Ventricular Assistance for Circulatory Support in Acute Coronary Artery Occlusion in the Pig: The Anstadt Cup , Dis Chest 53:502-506 ( (April) ) 1968.Crossref 7. Skinner, D.B.; Anstadt, G.L.; and Camp, T.F., Jr.: Acute Circulatory Support by Mechanical Ventricular Assistance Following Myocardial Infarction , J Thorac Cardiovasc Surg 54:785-794 ( (Dec) ) 1967. 8. Anstadt, G.L.; Schiff, P.; and Baue, A.E.: Prolonged Circulatory Support by Direct Mechanical Ventricular Assistance , Trans Amer Soc Artif Intern Organs 12:72-79, 1966. 9. Lumb, G., and Hardy, L.B.: Technique for Dissection and Perfusion of Heart , Arch Path 77:233-238 ( (March) ) 1964.

Journal

Archives of Surgery – American Medical Association

Published: Jun 1, 1969

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