REVIEW ARTICLE Individual Patient Data Meta-analysis Andrew J. Vickers, DPhil; Angel M. Cronin, MS; Alexandra C. Maschino, BS; George Lewith, MD; Hugh MacPherson, PhD; Nadine E. Foster, DPhil; Karen J. Sherman, PhD; Claudia M. Witt, MD; Klaus Linde, MD; for the Acupuncture Trialists’ Collaboration Background: Although acupuncture is widely used for (95% CI, 0.13-0.33), 0.16 (95% CI, 0.07-0.25), and 0.15 chronic pain, there remains considerable controversy as (95% CI, 0.07-0.24) SDs lower than sham controls for to its value. We aimed to determine the effect size of acu- back and neck pain, osteoarthritis, and chronic head- puncture for 4 chronic pain conditions: back and neck ache, respectively; the effect sizes in comparison to no- pain, osteoarthritis, chronic headache, and shoulder pain. acupuncture controls were 0.55 (95% CI, 0.51-0.58), 0.57 (95% CI, 0.50-0.64), and 0.42 (95% CI, 0.37-0.46) SDs. Methods: We conducted a systematic review to iden- These results were robust to a variety of sensitivity analy- tify randomized controlled trials (RCTs) of acupunc- ses, including those related to publication bias. ture for chronic pain in which allocation concealment was determined unambiguously to be adequate. Indi- Conclusions: Acupuncture is effective for the treat- vidual patient data meta-analyses were conducted using
JAMA Internal Medicine – American Medical Association
Published: Oct 22, 2012
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