REVIEW ARTICLE Individual Patient Data Meta-analysis Andrew J. Vickers, DPhil; Angel M. Cronin, MS; Alexandra C. Maschino, BS; George Lewith, MD; Hugh MacPherson, PhD; Nadine E. Foster, DPhil; Karen J. Sherman, PhD; Claudia M. Witt, MD; Klaus Linde, MD; for the Acupuncture Trialists’ Collaboration Background: Although acupuncture is widely used for (95% CI, 0.13-0.33), 0.16 (95% CI, 0.07-0.25), and 0.15 chronic pain, there remains considerable controversy as (95% CI, 0.07-0.24) SDs lower than sham controls for to its value. We aimed to determine the effect size of acu- back and neck pain, osteoarthritis, and chronic head- puncture for 4 chronic pain conditions: back and neck ache, respectively; the effect sizes in comparison to no- pain, osteoarthritis, chronic headache, and shoulder pain. acupuncture controls were 0.55 (95% CI, 0.51-0.58), 0.57 (95% CI, 0.50-0.64), and 0.42 (95% CI, 0.37-0.46) SDs. Methods: We conducted a systematic review to iden- These results were robust to a variety of sensitivity analy- tify randomized controlled trials (RCTs) of acupunc- ses, including those related to publication bias. ture for chronic pain in which allocation concealment was determined unambiguously to be adequate. Indi- Conclusions: Acupuncture is effective for the treat- vidual patient data meta-analyses were conducted using
JAMA Internal Medicine – American Medical Association
Published: Oct 22, 2012
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera