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ACTION OF ATOPHAN AND NOVATOPHAN IN GOUT AND IRITIS

ACTION OF ATOPHAN AND NOVATOPHAN IN GOUT AND IRITIS Abstract Since the work of Nicolaier and Dohrn1 showing an increased elimination of uric acid, due to the action of 2-phenylquinolin-4-carboxylic acid (atophan), a great deal of work has been done by many investigators with this substance. All get results showing an increased elimination, but all are not in accord in explaining the mechanism by which this increased elimination is obtained. Weintraud,2 as well as Frank and Bauch,3 have concluded from results of experiments in which uric acid was injected and sodium nucleinate was fed, that the atophan acts by increasing the efficiency of the kidney for uric acid elimination. Deutsch,4 Folin and Lyman5 and Zuelzer6 have reached the same conclusion by showing a decrease in the uric acid content of the blood, after the administration of atophan. Retzlaff7 and Brugsch,8 as well as Gudzent, Klemperer and Dohrn (cited References 1. Nicolaier, A., and Dohrn, M.: Ueber die Wirkung von Chinolincarbonsäure und ihre Derivate auf die Ausscheidung der Harnsäure , Deutsch. Arch. f. inn. Med. , 1908, xciii, 331. 2. Weintraud, W.: Zur Wirkung der Stophan bei Gicht , Verhand. d. deutsch. Kong. f. inn. Med. , 1911, p. 482. 3. Frank, E., and Bauch, B.: Ueber den Angriffspunkt des Atophans bei seiner Einwirkung auf die Harnsäure Ausscheidung . . . Berl. klin. Wchnschr. , 1911, xlviii, 1463. 4. Deutsch. F.: Ueber die Wirkung des Atophans bei Gesunden und Gichtkranken , München. med. Wchnschr. , 1911, lviii, 2652. 5. Folin, O., and Lyman, H.: On the Influence of Phenylquinolin Carbonic Acid (Atophan) on the Uric Acid Elimination , Jour. Pharm. and Exper. Ther. , 1912-13, iv, 539. 6. Zuelzer, G.: Ueber die Diagnose der Gicht durch Atophan , Berl. klin. Wchnschr. , 1911, xlviii, 2101. 7. Retzlaff : Ueber Atophan Therapie bei der Gicht , Deutsch. med. Wchnschr. , 1912, xxxviii, 404. 8. Brugsch, T.: Diagnose, Wesen und Behandlung der Gicht , Berl. klin. Wchnschr. , 1912, xlix, 1597. 9. Daniels, Amy L.: The Influence of Lithium and Atophan on the Uric Acid Excretion of a Gouty Patient , The Archives Int. Med. , 1914, xiii, 480.Crossref 10. Abl: Arch. f. exper. Path. u. Pharmakol. , 1914, lxxiv, 119. 11. Richter, Paul Friedrich: Ueber Wesen und Behandlungen der Gicht , Deutsch. med. Wchnschr. , 1911, xxxvii, 2361.Crossref 12. Haskins, H. D.: The Effect of Atophan and Novatophan on the Endogenous Uric Acid Excretion of Normal Men , Jour. Pharm. and Exper. Ther. , 1913, v, 63. 13. Starkenstein, E., and Wiechowski, W. : Ueber die Pharmakologie des Atrophaus , Prager med. Wchnschr. , 1913. 14. Herrick, W. W.: A Scarlatiniform Rash from Atophan , Jour. Am. Med. Assn. , 1913, lxi, 1376.Crossref 15. Skorczewski, W., and Sohn, I.: Ueber einige in Atophanharne auftretende characteristische Reaktionen , Wien. klin. Wchnschr. , 1911, xxiv, 1700. 16. Dohrn, Max : Ueber Farbreaktion speziell die Diazoreaktion im Atophanharn , München. med. Wchnschr. , 1912, lix, 568. 17. Folin, O., and Denis, W.: A New (Colorimetric) Method for the Determination of Uric Acid in Blood , Jour. Biol. Chem. , 1913, xiii, 469. 18. Personal communication. 19. Folin, O., and Denis, W.: Jour. Biol. Chem. , 1913, xiv, 95. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

ACTION OF ATOPHAN AND NOVATOPHAN IN GOUT AND IRITIS

Archives of Internal Medicine , Volume XV (2) – Feb 1, 1915

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Publisher
American Medical Association
Copyright
Copyright © 1915 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1915.00070200003001
Publisher site
See Article on Publisher Site

Abstract

Abstract Since the work of Nicolaier and Dohrn1 showing an increased elimination of uric acid, due to the action of 2-phenylquinolin-4-carboxylic acid (atophan), a great deal of work has been done by many investigators with this substance. All get results showing an increased elimination, but all are not in accord in explaining the mechanism by which this increased elimination is obtained. Weintraud,2 as well as Frank and Bauch,3 have concluded from results of experiments in which uric acid was injected and sodium nucleinate was fed, that the atophan acts by increasing the efficiency of the kidney for uric acid elimination. Deutsch,4 Folin and Lyman5 and Zuelzer6 have reached the same conclusion by showing a decrease in the uric acid content of the blood, after the administration of atophan. Retzlaff7 and Brugsch,8 as well as Gudzent, Klemperer and Dohrn (cited References 1. Nicolaier, A., and Dohrn, M.: Ueber die Wirkung von Chinolincarbonsäure und ihre Derivate auf die Ausscheidung der Harnsäure , Deutsch. Arch. f. inn. Med. , 1908, xciii, 331. 2. Weintraud, W.: Zur Wirkung der Stophan bei Gicht , Verhand. d. deutsch. Kong. f. inn. Med. , 1911, p. 482. 3. Frank, E., and Bauch, B.: Ueber den Angriffspunkt des Atophans bei seiner Einwirkung auf die Harnsäure Ausscheidung . . . Berl. klin. Wchnschr. , 1911, xlviii, 1463. 4. Deutsch. F.: Ueber die Wirkung des Atophans bei Gesunden und Gichtkranken , München. med. Wchnschr. , 1911, lviii, 2652. 5. Folin, O., and Lyman, H.: On the Influence of Phenylquinolin Carbonic Acid (Atophan) on the Uric Acid Elimination , Jour. Pharm. and Exper. Ther. , 1912-13, iv, 539. 6. Zuelzer, G.: Ueber die Diagnose der Gicht durch Atophan , Berl. klin. Wchnschr. , 1911, xlviii, 2101. 7. Retzlaff : Ueber Atophan Therapie bei der Gicht , Deutsch. med. Wchnschr. , 1912, xxxviii, 404. 8. Brugsch, T.: Diagnose, Wesen und Behandlung der Gicht , Berl. klin. Wchnschr. , 1912, xlix, 1597. 9. Daniels, Amy L.: The Influence of Lithium and Atophan on the Uric Acid Excretion of a Gouty Patient , The Archives Int. Med. , 1914, xiii, 480.Crossref 10. Abl: Arch. f. exper. Path. u. Pharmakol. , 1914, lxxiv, 119. 11. Richter, Paul Friedrich: Ueber Wesen und Behandlungen der Gicht , Deutsch. med. Wchnschr. , 1911, xxxvii, 2361.Crossref 12. Haskins, H. D.: The Effect of Atophan and Novatophan on the Endogenous Uric Acid Excretion of Normal Men , Jour. Pharm. and Exper. Ther. , 1913, v, 63. 13. Starkenstein, E., and Wiechowski, W. : Ueber die Pharmakologie des Atrophaus , Prager med. Wchnschr. , 1913. 14. Herrick, W. W.: A Scarlatiniform Rash from Atophan , Jour. Am. Med. Assn. , 1913, lxi, 1376.Crossref 15. Skorczewski, W., and Sohn, I.: Ueber einige in Atophanharne auftretende characteristische Reaktionen , Wien. klin. Wchnschr. , 1911, xxiv, 1700. 16. Dohrn, Max : Ueber Farbreaktion speziell die Diazoreaktion im Atophanharn , München. med. Wchnschr. , 1912, lix, 568. 17. Folin, O., and Denis, W.: A New (Colorimetric) Method for the Determination of Uric Acid in Blood , Jour. Biol. Chem. , 1913, xiii, 469. 18. Personal communication. 19. Folin, O., and Denis, W.: Jour. Biol. Chem. , 1913, xiv, 95.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Feb 1, 1915

References

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