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Acrodermatitis Enteropathica: Successful Zinc Therapy

Acrodermatitis Enteropathica: Successful Zinc Therapy Abstract • Acrodermatitis enteropathica (AE) is a familial syndrome with a high incidence of morbidity and mortality. The pathogenesis is unknown. Diiodohydroxyquin and related preparations have been the mainstay of treatment for the past 20 years. Recent evidence indicates that zinc therapy given orally may be the most effective treatment. We will describe the case of a 21-year-old woman who had had AE since she was 3 months old. Successful results were obtained with zinc therapy alone. (Arch Dermatol 112:1304-1307, 1976) References 1. Danbolt N, Closs K: Acrodermatitis enteropathica . Acta Derm Venereol 23:127-169, 1942. 2. Danbolt N: Acrodermatitis enteropathica: Report of two additional cases . Acta Derm Venereol 28:532-543, 1948. 3. Hansson 0: Acrodermatitis enteropathica: Report of two cases with a hypothesis concerning the pathogenesis of the disease . Acta Derm Venereol 43:465-471, 1963. 4. Cash R, Berger CK: Acrodermatitis enteropathica: Defective metabolism of unsaturated fatty acids . J Pediatr 74:717-729, 1969.Crossref 5. White HB Jr, Montalvo JM: Serum fatty acids before and after recovery from acrodermatitis enteropathica: Comparison of an infant with her family . J Pediatr 83:999-1006, 1973.Crossref 6. Robertson AF, Schuerger GS, Brown RR, et al: Tryptophan metabolism in acrodermatitis enteropathica . J Pediatr 83:1012-1016, 1973.Crossref 7. Neldner KH, Hagler L, Wise WR, et al: Acrodermatitis enteropathica: A clinical and biochemical survey . Arch Dermatol 110:711-721, 1974.Crossref 8. Moynahan EJ: Acrodermatitis enteropathica: A lethal inherited human zinc-deficiency disorder . Lancet 2:399-400, 1974.Crossref 9. Dillaha CJ, Lorincz AL, Aavik OR: Acrodermatitis enteropathica: Review of the literature and report of a case successfully treated with diodoquin . JAMA 152:509-512, 1953.Crossref 10. Berggren L, Hansson 0: Treating acrodermatitis enteropathica . Lancet 1:52, 1966.Crossref 11. Neldner KH, Hambridge KM: Zinc therapy of acrodermatitis enteropathica . N Engl J Med 292:879-882, 1975.Crossref 12. Barnes PM, Moynahan EJ: Zinc deficiency in acrodermatitis enteropathica: Multiple dietary intolerance treated with synthetic diet . Proc Roy Soc Med 66:327-329, 1973. 13. Moynahan, cited by Michaëlsson G: Zinc therapy in acrodermatitis enteropathica . Acta Derm Venereol 54:377-381, 1974. 14. Thyresson N: Acrodermatitis enteropathica: Report of a case healed with zinc therapy . Acta Derm Venereol 54:383-385, 1974. 15. Portnoy B, Molokhia M: Zinc in acrodermatitis enteropathica . Lancet 2:663-664, 1974.Crossref 16. Michaëlsson G: Zinc therapy in acrodermatitis enteropathica . Acta Derm Venereol 54:377-381, 1974. 17. Neldner KH, Hambridge KM, Walravens PA: Zinc therapy of acrodermatitis enteropathica (AE) , abstracted. Read before a joint meeting of the Society of Investigative Dermatology and the European Society for Dermatological Research, Amsterdam, 1975 . 18. Cooper LF, Barber EM, Mitchell HS, et al: Nutrition in Health and Disease . Philadelphia, JB Lippincott Co, 1958, pp 66 and 597. 19. Mills CF, Quarterman J, Chesters JK, et al: Metabolic Role of Zinc . Am J Clin Nutr 22:1240-1249, 1969. 20. Zinc deficiency in man, editorial . Lancet 1:299, 1973. 21. Tucker HF, Salmon WD: Parakeratosis or zinc deficiency in the pig . Proc Soc Exp Biol Med 88:613-616, 1955.Crossref 22. O'Dell BL, Newberne PM, Savage JE: Significance of dietary zinc for the growing chicken . 65:503-518, 1958. 23. Guthrie HA: Introductory Nutrition . St Louis, CV Mosby Co, 1971, pp 160-162. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Acrodermatitis Enteropathica: Successful Zinc Therapy

Archives of Dermatology , Volume 112 (9) – Sep 1, 1976

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Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1976.01630330066019
Publisher site
See Article on Publisher Site

Abstract

Abstract • Acrodermatitis enteropathica (AE) is a familial syndrome with a high incidence of morbidity and mortality. The pathogenesis is unknown. Diiodohydroxyquin and related preparations have been the mainstay of treatment for the past 20 years. Recent evidence indicates that zinc therapy given orally may be the most effective treatment. We will describe the case of a 21-year-old woman who had had AE since she was 3 months old. Successful results were obtained with zinc therapy alone. (Arch Dermatol 112:1304-1307, 1976) References 1. Danbolt N, Closs K: Acrodermatitis enteropathica . Acta Derm Venereol 23:127-169, 1942. 2. Danbolt N: Acrodermatitis enteropathica: Report of two additional cases . Acta Derm Venereol 28:532-543, 1948. 3. Hansson 0: Acrodermatitis enteropathica: Report of two cases with a hypothesis concerning the pathogenesis of the disease . Acta Derm Venereol 43:465-471, 1963. 4. Cash R, Berger CK: Acrodermatitis enteropathica: Defective metabolism of unsaturated fatty acids . J Pediatr 74:717-729, 1969.Crossref 5. White HB Jr, Montalvo JM: Serum fatty acids before and after recovery from acrodermatitis enteropathica: Comparison of an infant with her family . J Pediatr 83:999-1006, 1973.Crossref 6. Robertson AF, Schuerger GS, Brown RR, et al: Tryptophan metabolism in acrodermatitis enteropathica . J Pediatr 83:1012-1016, 1973.Crossref 7. Neldner KH, Hagler L, Wise WR, et al: Acrodermatitis enteropathica: A clinical and biochemical survey . Arch Dermatol 110:711-721, 1974.Crossref 8. Moynahan EJ: Acrodermatitis enteropathica: A lethal inherited human zinc-deficiency disorder . Lancet 2:399-400, 1974.Crossref 9. Dillaha CJ, Lorincz AL, Aavik OR: Acrodermatitis enteropathica: Review of the literature and report of a case successfully treated with diodoquin . JAMA 152:509-512, 1953.Crossref 10. Berggren L, Hansson 0: Treating acrodermatitis enteropathica . Lancet 1:52, 1966.Crossref 11. Neldner KH, Hambridge KM: Zinc therapy of acrodermatitis enteropathica . N Engl J Med 292:879-882, 1975.Crossref 12. Barnes PM, Moynahan EJ: Zinc deficiency in acrodermatitis enteropathica: Multiple dietary intolerance treated with synthetic diet . Proc Roy Soc Med 66:327-329, 1973. 13. Moynahan, cited by Michaëlsson G: Zinc therapy in acrodermatitis enteropathica . Acta Derm Venereol 54:377-381, 1974. 14. Thyresson N: Acrodermatitis enteropathica: Report of a case healed with zinc therapy . Acta Derm Venereol 54:383-385, 1974. 15. Portnoy B, Molokhia M: Zinc in acrodermatitis enteropathica . Lancet 2:663-664, 1974.Crossref 16. Michaëlsson G: Zinc therapy in acrodermatitis enteropathica . Acta Derm Venereol 54:377-381, 1974. 17. Neldner KH, Hambridge KM, Walravens PA: Zinc therapy of acrodermatitis enteropathica (AE) , abstracted. Read before a joint meeting of the Society of Investigative Dermatology and the European Society for Dermatological Research, Amsterdam, 1975 . 18. Cooper LF, Barber EM, Mitchell HS, et al: Nutrition in Health and Disease . Philadelphia, JB Lippincott Co, 1958, pp 66 and 597. 19. Mills CF, Quarterman J, Chesters JK, et al: Metabolic Role of Zinc . Am J Clin Nutr 22:1240-1249, 1969. 20. Zinc deficiency in man, editorial . Lancet 1:299, 1973. 21. Tucker HF, Salmon WD: Parakeratosis or zinc deficiency in the pig . Proc Soc Exp Biol Med 88:613-616, 1955.Crossref 22. O'Dell BL, Newberne PM, Savage JE: Significance of dietary zinc for the growing chicken . 65:503-518, 1958. 23. Guthrie HA: Introductory Nutrition . St Louis, CV Mosby Co, 1971, pp 160-162.

Journal

Archives of DermatologyAmerican Medical Association

Published: Sep 1, 1976

References