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Acquired Reversible Autistic Syndrome in Acute Encephalopathic Illness in Children

Acquired Reversible Autistic Syndrome in Acute Encephalopathic Illness in Children Abstract • In seeking the neurologic substrate of the autistic syndrome of childhood, previous studies have implicated the medial temporal lobe or the ring of mesolimbic cortex located in the mesial frontal and temporal lobes. During an acute encephalopathic illness, a clinical picture developed in three children that was consistent with infantile autism. This development was reversible. It was differentiated from acquired epileptic aphasia, and the language disorder was differentiated from aphasia. One child had rises in serum herpes simplex titers, and a computerized tomographic (CT) scan revealed an extensive lesion of the temporal lobes, predominantly on the left. The other two, with similar clinical syndromes, had normal CT scans, and no etiologic agent was defined. These cases are examples of ah acquired and reversible autistic syndrome in childhood, emphasizing the clinical similarities to bilateral medial temporal lobe disease as described in man, including the Klüver-Bucy syndrome seen in postencephalitic as well as postsurgical states. References 1. Rutter M: Diagnosis and definition of childhood autism . J Autism Child Schizophr 1978;8:139-161.Crossref 2. Damasio AR, Maurer RG: A neurological model for childhood autism . Arch Neurol 1978;35:777-786.Crossref 3. Hauser SL, DeLong GR, Rosman NP: Pneumographic findings in the infantile autism syndrome: A correlation with temporal lobe disease . Brain 1975;98:667-688.Crossref 4. DeLong GR: A neuropsychological interpretation of infantile autism , in Rutter M, Shopler E (eds): Autism: A Reappraisal of Concepts and Treatment . New York, Plenum Press, 1978, pp 207-218. 5. Boucher J, Warrington EK: Memory deficits in early infantile autism: Some similarities to the amnesic syndrome . Br J Psychol 1976;67:73-87.Crossref 6. Boucher J: Alternation and sequencing behaviour, and response to novelty in autistic children . J Child Psychol Psychiatry 1977;18:67-72.Crossref 7. Bartak L, Rutter M, Cox A: A comparative study of infantile autism and specific developmental receptive language disorders: I. The children . Br J Psychiatry 1975;126:127-145.Crossref 8. Bartak L, Rutter M, Cox A: A comparative study of infantile autism and specific developmental receptive language disorders: III. Discriminant function analysis . J Autism Child Schizophr 1977;7:383-396.Crossref 9. Landau WM, Kleffner FR: Syndrome of acquired aphasia with convulsive disorder in children . Neurology 1957;7:523-530.Crossref 10. Worster-Drought C: An unusual form of acquired aphasia in children . Dev Med Child Neurol 1971;13:563-571.Crossref 11. Gascon G, Victor D, Lombroso CT, et al: Language disorder, convulsive disorder, and electroencephalographic abnormalities . Arch Neurol 1973;28:156-162.Crossref 12. Terzian H, Delleore G: Syndrome of Klüver and Bucy reproduced in man by bilateral removal of the temporal lobes . Neurology 1955;3:373-380.Crossref 13. Marlowe WB, Maxcall EL, Thomas JJ: Complete Klüver-Bucy syndrome in man . Cortex 1975;11:53-59.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Acquired Reversible Autistic Syndrome in Acute Encephalopathic Illness in Children

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Publisher
American Medical Association
Copyright
Copyright © 1981 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1981.00510030085013
Publisher site
See Article on Publisher Site

Abstract

Abstract • In seeking the neurologic substrate of the autistic syndrome of childhood, previous studies have implicated the medial temporal lobe or the ring of mesolimbic cortex located in the mesial frontal and temporal lobes. During an acute encephalopathic illness, a clinical picture developed in three children that was consistent with infantile autism. This development was reversible. It was differentiated from acquired epileptic aphasia, and the language disorder was differentiated from aphasia. One child had rises in serum herpes simplex titers, and a computerized tomographic (CT) scan revealed an extensive lesion of the temporal lobes, predominantly on the left. The other two, with similar clinical syndromes, had normal CT scans, and no etiologic agent was defined. These cases are examples of ah acquired and reversible autistic syndrome in childhood, emphasizing the clinical similarities to bilateral medial temporal lobe disease as described in man, including the Klüver-Bucy syndrome seen in postencephalitic as well as postsurgical states. References 1. Rutter M: Diagnosis and definition of childhood autism . J Autism Child Schizophr 1978;8:139-161.Crossref 2. Damasio AR, Maurer RG: A neurological model for childhood autism . Arch Neurol 1978;35:777-786.Crossref 3. Hauser SL, DeLong GR, Rosman NP: Pneumographic findings in the infantile autism syndrome: A correlation with temporal lobe disease . Brain 1975;98:667-688.Crossref 4. DeLong GR: A neuropsychological interpretation of infantile autism , in Rutter M, Shopler E (eds): Autism: A Reappraisal of Concepts and Treatment . New York, Plenum Press, 1978, pp 207-218. 5. Boucher J, Warrington EK: Memory deficits in early infantile autism: Some similarities to the amnesic syndrome . Br J Psychol 1976;67:73-87.Crossref 6. Boucher J: Alternation and sequencing behaviour, and response to novelty in autistic children . J Child Psychol Psychiatry 1977;18:67-72.Crossref 7. Bartak L, Rutter M, Cox A: A comparative study of infantile autism and specific developmental receptive language disorders: I. The children . Br J Psychiatry 1975;126:127-145.Crossref 8. Bartak L, Rutter M, Cox A: A comparative study of infantile autism and specific developmental receptive language disorders: III. Discriminant function analysis . J Autism Child Schizophr 1977;7:383-396.Crossref 9. Landau WM, Kleffner FR: Syndrome of acquired aphasia with convulsive disorder in children . Neurology 1957;7:523-530.Crossref 10. Worster-Drought C: An unusual form of acquired aphasia in children . Dev Med Child Neurol 1971;13:563-571.Crossref 11. Gascon G, Victor D, Lombroso CT, et al: Language disorder, convulsive disorder, and electroencephalographic abnormalities . Arch Neurol 1973;28:156-162.Crossref 12. Terzian H, Delleore G: Syndrome of Klüver and Bucy reproduced in man by bilateral removal of the temporal lobes . Neurology 1955;3:373-380.Crossref 13. Marlowe WB, Maxcall EL, Thomas JJ: Complete Klüver-Bucy syndrome in man . Cortex 1975;11:53-59.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Mar 1, 1981

References