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Acquired Immunity to Dermatophytes

Acquired Immunity to Dermatophytes Abstract Experimental dermatophyte (Trichophyton mentagrophytes) infections were initiated by using quantified spore inoculi on the forearms of 13 healthy volunteers who manifested no evidence of prior infection. Active lesions typical of tinea corporis developed. Following the emergence of delayed-type hypersensitivity, the lesions resolved spontaneously. Subsequently, seven of the now immunologically experienced volunteers were reinoculated. Early, atypical inflammatory lesions developed. There was no spread of infection, the organism rapidly disappeared, and the course of infection was shortened. The number of spores required to initiate an infection that persisted three weeks increased from less than six to approximately 300. Thus, the acquired immunity was relative. Cell-mediated immunity correlated with this enhanced resistance. Cell-mediated immunity is hypothesized to act indirectly by destroying the "privileged" nature of the stratum corneum. References 1. Bloch BR, Massini R: Studien uber immunitat und uberemptindlichkeit bei hyphomyzetenerkrankungen . Zeit Hygiene Infektionskrankheiten 63:68-89, 1909.Crossref 2. De Lamater ED, Benham RW: Experimental studies with the dermatophytes: I. Primary disease in laboratory animals . J Invest Dermatol 1:451-467, 1938.Crossref 3. De Lamater ED, Benham RW: Experimental studies with the dermatophytes: II. Immunity and hypersensitivity produced in laboratory animals . J Invest Dermatol 1:469-488, 1938.Crossref 4. De Lamater ED: Experimental studies with the dermatophytes: III. Development and duration of immunity and hypersensitivity in guinea pigs . J Invest Dermatol 4:143-158, 1941.Crossref 5. Lepper AWD: Immunological aspects of dermatomycoses in animals and man . Rev Med Vet Mycol 6:435-446, 1969. 6. Knight MB: A review of experimental human fungus infections . J Invest Dermatol 59:354-358, 1973.Crossref 7. Sloper JC: A study of experimental human infections due to Trichophyton rubrum, Trichophyton mentagrophytes and Epidermophyton floccosum, with particular reference to the selflimitation of the resultant lesions . J Invest Dermatol 25:21-28, 1955.Crossref 8. Desai SC: Immunology of dermatophytosis, Symposium VII Fungus diseases , in Pillsbury DM, Livingood CS (eds): Proceedings of the International Congress of Dermatology . Amsterdam, Excerpta Medica Foundation, 1962, pp 557-562. 9. Desai SC, Bhat MLA: Studies on experimental infections with T rubrum in humans and the mechanism of griseovulvin effect . J Invest Dermatol 35:297-303, 1960.Crossref 10. Desai SC, Bhat MLA, Modi PJ: Biology of T rubrum infections . Indian J Med Res 51:233-242, 1963: 11. Braun W: New views on immunobiology in trichophytosis , in Hegyi E (ed): Recent Advances of Human and Animal Mycology . Bratislava, Czechoslovakia, Publishing House of the Slovak Academy of Science, 1967, pp 301-303. 12. Sonck CE: Repeated inoculations of microsporon into human skin , in Hegyi E (ed): Recent Advances of Human and Animal Mycology . Bratislava, Czechoslovakia, Publishing House of the Slovak Academy of Science, 1967, pp 113-114. 13. Greenbaum SS: Immunity in ringworm infections . Arch Dermatol 10:279-288, 1924.Crossref 14. Epstein S, Grunmandel S: Untersuchungen über die spontane abhleilung von oberflachlichen trichophytien . Arch Dermatol Syphilol 161:395-428, 1930.Crossref 15. Huppert M, Keeney EL: Immunization against superficial fungus infection: II. Studies on human volunteer subjects . J Invest Dermatol 32:15-19, 1959. 16. Cruickshank CND, Trotter MD, Wood SR: Studies on trichophytin sensitivity . J Invest Dermatol 35:219-223, 1960.Crossref 17. Wood SR, Cruickshank CND: The relation between trichophytin sensitivity and fungal infection . Br J Dermatol 74:329-336, 1962.Crossref 18. Barker SA, Cruickshank CND, Holden JH: Structure of a galactomannan peptide allergen from Trichophyton mentagrophytes . Biochim Biophys Acta 74:239-246, 1963.Crossref 19. Allen AM, et al: Griseovulvin in the prevention of experimental human dermatophytosis . Arch Dermatol 108:233-236, 1973.Crossref 20. Jones HE, Reinhardt J, Rinaldi M: A clinical, mycological and immunological survey for dermatophytosis . Arch Dermatol 108:61-64, 1973.Crossref 21. Taplin D, et al: Isolation and recognition of dermatophytes on a new medium (DTM) . Arch Dermatol 99:203-209, 1969.Crossref 22. Ajello L, et al: Laboratory Manual for Medical Mycology , publication 994. Public Health Service 1963. 23. Rebell G, Taplin D: Dermatophytes: Their Recognition and Identification . Miami, Fla, University of Miami Press, 1970. 24. Jones HE: Delayed Type Skin Reaction and Lymphocyte Transformation in Cutaneous Diseases . Annual progress report, FY 1972. San Francisco, Letterman Army Institute of Research, 1972. 25. Fisher AA: Contact Dermatitis . Philadelphia, Lea & Febiger, 1967, p 86. 26. Koch R: Weitere mittheilungen über ein heilmittel gegen tuberkulose . Dtsch Med Wochenschr 16:1029-1032, 1890.Crossref 27. Gonzalez-Ochoa A, Cordova J: Sensitization factor in the dermatophytes of the glabrous skin . Acta Derm Venereol 3:1179-1183, 1957. 28. Roth FJ, et al: An evaluation of the fungistatic activity of serum . J Invest Dermatol 32:549-556, 1959.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1974 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1974.01630060018003
Publisher site
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Abstract

Abstract Experimental dermatophyte (Trichophyton mentagrophytes) infections were initiated by using quantified spore inoculi on the forearms of 13 healthy volunteers who manifested no evidence of prior infection. Active lesions typical of tinea corporis developed. Following the emergence of delayed-type hypersensitivity, the lesions resolved spontaneously. Subsequently, seven of the now immunologically experienced volunteers were reinoculated. Early, atypical inflammatory lesions developed. There was no spread of infection, the organism rapidly disappeared, and the course of infection was shortened. The number of spores required to initiate an infection that persisted three weeks increased from less than six to approximately 300. Thus, the acquired immunity was relative. Cell-mediated immunity correlated with this enhanced resistance. Cell-mediated immunity is hypothesized to act indirectly by destroying the "privileged" nature of the stratum corneum. References 1. Bloch BR, Massini R: Studien uber immunitat und uberemptindlichkeit bei hyphomyzetenerkrankungen . Zeit Hygiene Infektionskrankheiten 63:68-89, 1909.Crossref 2. De Lamater ED, Benham RW: Experimental studies with the dermatophytes: I. Primary disease in laboratory animals . J Invest Dermatol 1:451-467, 1938.Crossref 3. De Lamater ED, Benham RW: Experimental studies with the dermatophytes: II. Immunity and hypersensitivity produced in laboratory animals . J Invest Dermatol 1:469-488, 1938.Crossref 4. De Lamater ED: Experimental studies with the dermatophytes: III. Development and duration of immunity and hypersensitivity in guinea pigs . J Invest Dermatol 4:143-158, 1941.Crossref 5. Lepper AWD: Immunological aspects of dermatomycoses in animals and man . Rev Med Vet Mycol 6:435-446, 1969. 6. Knight MB: A review of experimental human fungus infections . J Invest Dermatol 59:354-358, 1973.Crossref 7. Sloper JC: A study of experimental human infections due to Trichophyton rubrum, Trichophyton mentagrophytes and Epidermophyton floccosum, with particular reference to the selflimitation of the resultant lesions . J Invest Dermatol 25:21-28, 1955.Crossref 8. Desai SC: Immunology of dermatophytosis, Symposium VII Fungus diseases , in Pillsbury DM, Livingood CS (eds): Proceedings of the International Congress of Dermatology . Amsterdam, Excerpta Medica Foundation, 1962, pp 557-562. 9. Desai SC, Bhat MLA: Studies on experimental infections with T rubrum in humans and the mechanism of griseovulvin effect . J Invest Dermatol 35:297-303, 1960.Crossref 10. Desai SC, Bhat MLA, Modi PJ: Biology of T rubrum infections . Indian J Med Res 51:233-242, 1963: 11. Braun W: New views on immunobiology in trichophytosis , in Hegyi E (ed): Recent Advances of Human and Animal Mycology . Bratislava, Czechoslovakia, Publishing House of the Slovak Academy of Science, 1967, pp 301-303. 12. Sonck CE: Repeated inoculations of microsporon into human skin , in Hegyi E (ed): Recent Advances of Human and Animal Mycology . Bratislava, Czechoslovakia, Publishing House of the Slovak Academy of Science, 1967, pp 113-114. 13. Greenbaum SS: Immunity in ringworm infections . Arch Dermatol 10:279-288, 1924.Crossref 14. Epstein S, Grunmandel S: Untersuchungen über die spontane abhleilung von oberflachlichen trichophytien . Arch Dermatol Syphilol 161:395-428, 1930.Crossref 15. Huppert M, Keeney EL: Immunization against superficial fungus infection: II. Studies on human volunteer subjects . J Invest Dermatol 32:15-19, 1959. 16. Cruickshank CND, Trotter MD, Wood SR: Studies on trichophytin sensitivity . J Invest Dermatol 35:219-223, 1960.Crossref 17. Wood SR, Cruickshank CND: The relation between trichophytin sensitivity and fungal infection . Br J Dermatol 74:329-336, 1962.Crossref 18. Barker SA, Cruickshank CND, Holden JH: Structure of a galactomannan peptide allergen from Trichophyton mentagrophytes . Biochim Biophys Acta 74:239-246, 1963.Crossref 19. Allen AM, et al: Griseovulvin in the prevention of experimental human dermatophytosis . Arch Dermatol 108:233-236, 1973.Crossref 20. Jones HE, Reinhardt J, Rinaldi M: A clinical, mycological and immunological survey for dermatophytosis . Arch Dermatol 108:61-64, 1973.Crossref 21. Taplin D, et al: Isolation and recognition of dermatophytes on a new medium (DTM) . Arch Dermatol 99:203-209, 1969.Crossref 22. Ajello L, et al: Laboratory Manual for Medical Mycology , publication 994. Public Health Service 1963. 23. Rebell G, Taplin D: Dermatophytes: Their Recognition and Identification . Miami, Fla, University of Miami Press, 1970. 24. Jones HE: Delayed Type Skin Reaction and Lymphocyte Transformation in Cutaneous Diseases . Annual progress report, FY 1972. San Francisco, Letterman Army Institute of Research, 1972. 25. Fisher AA: Contact Dermatitis . Philadelphia, Lea & Febiger, 1967, p 86. 26. Koch R: Weitere mittheilungen über ein heilmittel gegen tuberkulose . Dtsch Med Wochenschr 16:1029-1032, 1890.Crossref 27. Gonzalez-Ochoa A, Cordova J: Sensitization factor in the dermatophytes of the glabrous skin . Acta Derm Venereol 3:1179-1183, 1957. 28. Roth FJ, et al: An evaluation of the fungistatic activity of serum . J Invest Dermatol 32:549-556, 1959.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Jun 1, 1974

References