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Acquired Generalized Anhidrosis

Acquired Generalized Anhidrosis Abstract • A patient developed generalized anhidrosis, probably following sunstroke. Light microscopy showed an atrophic, deeply lobulated or elongated configuration of the eccrine sweat glands, most of them containing many vacuoles that possessed strong acid phosphatase activity. Electron microscopy revealed that the vacuoles were bound by a unit membrane and that the contents varied. Fusion of the vacuoles and accumulation of cellular debris in the lumen were also seen. It was concluded that the vacuoles showed areas of autolysis and were classified in the group of lysosomes. In addition, it is postulated that the anhidrosis resulted from a critical rise in body temperature with subsequent changes in the secretory cells. (Arch Dermatol 112:1310-1314, 1976) References 1. Chakravartia MDN, Tyagi N: A case of hemi-anhidrosis . J R Army Med Corps 72:336-337, 1939. 2. Da Costa JL, Tan KK, Seah CS: Generalized anhidrosis following exposure to radiant heat . Br J Dermatol 78:311-321, 1966.Crossref 3. Ichihashi T: Effect of drugs on sweat glands by cataphoresis, and effective method for suppression of local sweating: Antisudorific effect of formalin by cataphoretic application, and its practical use . J Orient Med 25:105-106, 1936. 4. Sulzberger MB, Zack FG, Herrmann F: Studies of sweating: On mechanism of action of local antiperspirants . Arch Dermatol Syphilol 60:404-418, 1949.Crossref 5. Shelley WB, Horvath PN, Pillsbury DM: Anhidrosis: An etiologic interpretation . Medicine 29:195-224, 1950.Crossref 6. Barka T, Anderson P: Phosphatases , in Histochemistry . New York, Harper & Row Publishers Inc, 1963, pp 244-246. 7. Luft JH: Improvement in epoxy resin embedding methods . J Biophys Biochem Cytol 9:409-414, 1961.Crossref 8. Terzakis JA: The ultrastructure of monkey eccrine sweat glands . Z Zellforsch Mikrosk Anat 64:493-509, 1964.Crossref 9. Saito K: Local sweating on heated area of skin in man . J Orient Med 13:53, 1930. 10. Randall WC: Local sweat gland activity due to direct effects of radiant heat . Am J Physiol 150:365-371, 1947. 11. Janowitz HD, Grossman MI: Response of sweat glands to some locally acting agents in human subjects . J Invest Dermatol 14:453-458, 1950. 12. Benjamin FB: Sweating response to local heat application . J Appl Physiol 5:594-598, 1953. 13. McLaughlin JT, Sonnenschein RR: Response of human sweat glands to local heating . J Invest Dermatol 41:27-29, 1963.Crossref 14. Kuno Y: The Physiology of Human Sweating . London, J & A Churchill, Ltd, 1934. 15. Engelhardt HT, Melvin JP Jr: General acquired anhydrosis . Am J Med Sci 210:323-328, 1945.Crossref 16. Fog M: General acquired anhidrosis: Report of a case and investigations of the heat regulation and circulation . JAMA 107:2040-2045, 1936.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Acquired Generalized Anhidrosis

Archives of Dermatology , Volume 112 (9) – Sep 1, 1976

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Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1976.01630330072021
Publisher site
See Article on Publisher Site

Abstract

Abstract • A patient developed generalized anhidrosis, probably following sunstroke. Light microscopy showed an atrophic, deeply lobulated or elongated configuration of the eccrine sweat glands, most of them containing many vacuoles that possessed strong acid phosphatase activity. Electron microscopy revealed that the vacuoles were bound by a unit membrane and that the contents varied. Fusion of the vacuoles and accumulation of cellular debris in the lumen were also seen. It was concluded that the vacuoles showed areas of autolysis and were classified in the group of lysosomes. In addition, it is postulated that the anhidrosis resulted from a critical rise in body temperature with subsequent changes in the secretory cells. (Arch Dermatol 112:1310-1314, 1976) References 1. Chakravartia MDN, Tyagi N: A case of hemi-anhidrosis . J R Army Med Corps 72:336-337, 1939. 2. Da Costa JL, Tan KK, Seah CS: Generalized anhidrosis following exposure to radiant heat . Br J Dermatol 78:311-321, 1966.Crossref 3. Ichihashi T: Effect of drugs on sweat glands by cataphoresis, and effective method for suppression of local sweating: Antisudorific effect of formalin by cataphoretic application, and its practical use . J Orient Med 25:105-106, 1936. 4. Sulzberger MB, Zack FG, Herrmann F: Studies of sweating: On mechanism of action of local antiperspirants . Arch Dermatol Syphilol 60:404-418, 1949.Crossref 5. Shelley WB, Horvath PN, Pillsbury DM: Anhidrosis: An etiologic interpretation . Medicine 29:195-224, 1950.Crossref 6. Barka T, Anderson P: Phosphatases , in Histochemistry . New York, Harper & Row Publishers Inc, 1963, pp 244-246. 7. Luft JH: Improvement in epoxy resin embedding methods . J Biophys Biochem Cytol 9:409-414, 1961.Crossref 8. Terzakis JA: The ultrastructure of monkey eccrine sweat glands . Z Zellforsch Mikrosk Anat 64:493-509, 1964.Crossref 9. Saito K: Local sweating on heated area of skin in man . J Orient Med 13:53, 1930. 10. Randall WC: Local sweat gland activity due to direct effects of radiant heat . Am J Physiol 150:365-371, 1947. 11. Janowitz HD, Grossman MI: Response of sweat glands to some locally acting agents in human subjects . J Invest Dermatol 14:453-458, 1950. 12. Benjamin FB: Sweating response to local heat application . J Appl Physiol 5:594-598, 1953. 13. McLaughlin JT, Sonnenschein RR: Response of human sweat glands to local heating . J Invest Dermatol 41:27-29, 1963.Crossref 14. Kuno Y: The Physiology of Human Sweating . London, J & A Churchill, Ltd, 1934. 15. Engelhardt HT, Melvin JP Jr: General acquired anhydrosis . Am J Med Sci 210:323-328, 1945.Crossref 16. Fog M: General acquired anhidrosis: Report of a case and investigations of the heat regulation and circulation . JAMA 107:2040-2045, 1936.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Sep 1, 1976

References