Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Acquired Deficiency and Urinary Excretion of Antithrombin III in Nephrotic Syndrome

Acquired Deficiency and Urinary Excretion of Antithrombin III in Nephrotic Syndrome Abstract • The published data concerning changes of antithrombin III (ATIII) In nephrotic syndrome (NS) are contradictory. While increased ATIII activity has been reported by some investigators, decreased concentration has been shown by others and normal values by yet another group of authors. We determined plasma and urine concentrations of ATIII in a group of 20 patients with NS using an immunologic assay. In addition, plasma ATIII activity was determined. The results were compared with those obtained in a group of normal volunteers. Plasma concentration and activity of ATIII were both greatly reduced in the patients with NS. In addition, substantial quantities of ATIII were recovered in the urine of all tested patients. The present study, therefore, substantiates the low plasma concentrations of ATIII and its urinary losses in NS. In addition, a parallel reduction in plasma ATIII activity is demonstrated providing functional evidence of acquired ATIII deficiency in this condition. (Arch Intern Med 1984;144:1802-1803) References 1. Kanfer A, Kleinknecht D, Broyer M, et al: Coagulation studies in 45 cases of nephrotic syndrome without uremia. Thromb Haemost 1970;24: 562-571. 2. Kaufmann RH, Veltkamp JJ, Van Tilburg NH, et al: Acquired antithrombin deficiency and thrombosis in nephrotic syndrome. Am J Med 1978;65:607-613.Crossref 3. Panicucci F, Sagripanti A, Vispi M, et al: Comprehensive study of haemostasis in nephrotic syndrome. Nephron 1983;33:9-13.Crossref 4. Ibsen KH, Ngo JLT, Sanders DA, et al: Use of the gradient plate immunodiffusion technique. J Immunol Methods 1983;56:381-387.Crossref 5. Abildgaard U, Gravem K, Godal HC: Assay of progressive antithrombin in plasma. Thromb Haemost 1970;24:224-229. 6. Howie PW, Prentice CRW, McNicol GP: A method of antithrombin estimation using plasma defibrinated with ancrod. Br J Haematol 1973;25:101-110.Crossref 7. Egeberg O: Inherited antithrombin deficiency causing thrombophilia. Thromb Haemost 1965;13:516-530. 8. Marciniak E, Farley CH, DeSimone PA: Familial thrombosis due to antithrombin III deficiency. Blood 1974;43:219-231. 9. Thomson C, Forbes CD, Prentice CRM, et al: Changes in blood coagulation and fibrinolysis in the nephrotic syndrome. Q J Med 1974;43: 399-407. 10. Abildgaard U, Fagerhol MK, Egeberg O: Comparison of progressive antithrombin activity and the concentrations of three thrombin inhibitors in human plasma. Scand J Clin Invest 1970;26:349-354.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Acquired Deficiency and Urinary Excretion of Antithrombin III in Nephrotic Syndrome

Loading next page...
 
/lp/american-medical-association/acquired-deficiency-and-urinary-excretion-of-antithrombin-iii-in-200lh1etNf
Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1984.00350210124021
Publisher site
See Article on Publisher Site

Abstract

Abstract • The published data concerning changes of antithrombin III (ATIII) In nephrotic syndrome (NS) are contradictory. While increased ATIII activity has been reported by some investigators, decreased concentration has been shown by others and normal values by yet another group of authors. We determined plasma and urine concentrations of ATIII in a group of 20 patients with NS using an immunologic assay. In addition, plasma ATIII activity was determined. The results were compared with those obtained in a group of normal volunteers. Plasma concentration and activity of ATIII were both greatly reduced in the patients with NS. In addition, substantial quantities of ATIII were recovered in the urine of all tested patients. The present study, therefore, substantiates the low plasma concentrations of ATIII and its urinary losses in NS. In addition, a parallel reduction in plasma ATIII activity is demonstrated providing functional evidence of acquired ATIII deficiency in this condition. (Arch Intern Med 1984;144:1802-1803) References 1. Kanfer A, Kleinknecht D, Broyer M, et al: Coagulation studies in 45 cases of nephrotic syndrome without uremia. Thromb Haemost 1970;24: 562-571. 2. Kaufmann RH, Veltkamp JJ, Van Tilburg NH, et al: Acquired antithrombin deficiency and thrombosis in nephrotic syndrome. Am J Med 1978;65:607-613.Crossref 3. Panicucci F, Sagripanti A, Vispi M, et al: Comprehensive study of haemostasis in nephrotic syndrome. Nephron 1983;33:9-13.Crossref 4. Ibsen KH, Ngo JLT, Sanders DA, et al: Use of the gradient plate immunodiffusion technique. J Immunol Methods 1983;56:381-387.Crossref 5. Abildgaard U, Gravem K, Godal HC: Assay of progressive antithrombin in plasma. Thromb Haemost 1970;24:224-229. 6. Howie PW, Prentice CRW, McNicol GP: A method of antithrombin estimation using plasma defibrinated with ancrod. Br J Haematol 1973;25:101-110.Crossref 7. Egeberg O: Inherited antithrombin deficiency causing thrombophilia. Thromb Haemost 1965;13:516-530. 8. Marciniak E, Farley CH, DeSimone PA: Familial thrombosis due to antithrombin III deficiency. Blood 1974;43:219-231. 9. Thomson C, Forbes CD, Prentice CRM, et al: Changes in blood coagulation and fibrinolysis in the nephrotic syndrome. Q J Med 1974;43: 399-407. 10. Abildgaard U, Fagerhol MK, Egeberg O: Comparison of progressive antithrombin activity and the concentrations of three thrombin inhibitors in human plasma. Scand J Clin Invest 1970;26:349-354.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Sep 1, 1984

References