Abstract A number of cases of agammaglobulinemia have been reported in the medical literature since Bruton1 described the first case in 1952. This condition is encountered more frequently because patients who are unable to produce antibodies against infection are surviving now with the aid of antibiotics. It is recognized more readily because a high index of suspicion of this is becoming widespread, and methods of establishing the diagnosis by the study of serum proteins are now available to most physicians. Two forms of isolated agammaglobulinemia exist: (1) a congential type. occuring as a recessive sex-linked trait in male children, with symptoms developing reduced form the normal of approximately 1,000 mg. % to less than 10 mg. %, and (2) an acquired type occurring in either sex, with symptoms developing in adulthood and serum γ-globulin levels of 20-40 mg. %. Such a distinction may be arbitrary and more apparent than real, for References 1. Bruton, O. C.: Agammaglobulinemia , Pediatrics 9:722, 1952. 2. Good, R. A.: Disturbances in Gamma Globulin Synthesis as Experiments of Nature , Pediatrics 18:109, 1950. 3. Bruton, O. C.; Apt, L.; Gitlin, D., and Janeway, C. A.: Absence of Serum Gamma Globulin , A. M. A. Am. J. Dis. Child. 84:632, 1952. 4. Clinical Staff Conference, National Institutes of Health: Agammaglobulinemia , Ann. Int. Med. 47:533, 1957.Crossref 5. Kuhns, W. J.; Ridley, E., Weigk, W.: Agammaglobulinemia: The Role of Hemagglutination Technics in Its Diagnosis , Am. J. Clin. Path. 26:750, 1956. 6. Prasad, A. S., and Koza, D. W.: Agammaglobulinemia , Ann. Int. Med. 41:629, 1954.Crossref 7. Elphinstone, R. H.; Wickes, I. G., and Anderson, A. B.: Familial Agammaglobulinemia , Brit. M. J. 2:336, 1956.Crossref 8. Brem, T. H., and Morton, M. E.: Defective Serum Gamma Globulin Formation , Ann. Int. Med. 43:465, 1955.Crossref 9. Keidan, S. E.; McCarthy, K., and Haworth, J. C.: Fatal Generalized Vaccinia with Failure of Antibody Production and Absence of Serum Gamma Globulin , Arch. Dis. Childhood 28:138, 1953.Crossref 10. Young, I. I., and Wolfson, W. Q.: The Agammaglobulinemia Syndrome in Adult Men , Clin. Res. Proc. 2:101, 1954. 11. Young, I. I.; Wolfson, W. Q., and Cohn, C.: Studies in Serum Proteins—Agammaglobulinemia in the Adult , Am. J. Med. 19:222, 1955.Crossref 12. Hayles, A. B.; Stickler, G. B., and McKenzie, B. F.: Decrease in Serum Gamma Globulin (Agammaglobulinemia) , Pediatrics 14:449, 1954. 13. Good, R. A., and Varco, R. L.: A Clinical and Experimental Study of Agammaglobulinemia , Journal-Lancet 75:245, 1955. 14. Martin, C. M.; Gordon, R. S., and McCullough, N. B.: Acquired Hypogammaglobulinemia in an Adult , New England J. Med. 254: 449, 1956.Crossref 15. Laski, B.; Sass-Korstak, A., and Hillman, D. A.: Cyclic Neutropenia with Agammaglobulinemia , A. M. A. Am. J. Dis. Child. 88:811, 1954. 16. Grant, G. H., and Wallace, W. D.: Agammaglobulinemia , Lancet 267:671, 1954.Crossref 17. Fischer, C. C.: Variations in Serum Gamma Globulin , Postgrad. Med. 17:406, 1955. 18. Rohn, R. J.; Behnke, R. H., and Bond, W. H.: Acquired Agammaglobulinemia with Hypersplenism , Am. J. M. Sc. 229:406, 1955.Crossref 19. Zinneman, H. H.; Hall, W. H., and Heller, B. I.: Acquired Agammaglobulinemia , J. A. M. A. 156:1390, 1954.Crossref 20. Arends, T.; Coonrad, E. V., and Rundles, R. W.: Serum Proteins in Hodgkins Disease and Malignant Lymphoma , Am. J. Med. 16:833, 1954.Crossref 21. Collins, H. D., and Dudley, H. R.: Agammaglobulinemia and Bronchiectasis , New England J. Med. 252:255, 1955.Crossref 22. Klayman, M. I., and Brandborg, L.: Clinical Application of Cobalt60 Labelled Vitamin B12 Urine Test , New England J. Med. 253:808, 1955.Crossref 23. Lewis, E. C., and Brown, H. E., Jr.: Agammaglobulinemia Associated with Pernicious Anemia and Diabetes Mellitus , A. M. A. Arch. Int. Med. 100:296, 1957.Crossref 24. Unglaub, W. G., and Goldsmith, G. A.: Folic Acid and Vitamin B12 in Medical Practice , J. A. M. A. 161:625, 1956. 25. Wechsler, H. F., and Wolf, M. J.: Agammaglobulinemia , J. A. M. A. 161:526, 1956.Crossref 26. Harris, T. N., and Harris, S.: The Genesis of Antibodies , Am. J. Med. 20:144, 1956.Crossref 27. Menzel, A. E. O.; Kessler, W. R.; Cooke, R. A., and Myers, P.: Immuno-Serologic Studies of the Immediate Wheal Type Allergies , J. Allergy 23:483, 1952.Crossref 28. Campbell, D. H.; Cann, J. R.; Friedman, T. B., and Brown, R. A.: Reagic Serum Fractions Obtained by the Electrophoresis-Convection Method , J. Allergy 21:519, 1950.Crossref 29. Williams, C. A., Jr., and Graybar, P.: Immunoelectrophoretic Studies on Serum Proteins , J. Immunol 74:158, 1955.
A.M.A. Archives of Internal Medicine – American Medical Association
Published: Mar 1, 1959
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