Abstract In some patients receiving corticotropin there develops an eruption which, in many respects, resembles acne vulgaris. Certain clinical features (Table 1) distinguish the drug eruption (Fig. 1) from acne vulgaris. The purpose of this report is to compare the histopathologic features of the two conditions. MATERIAL Biopsy specimens were taken from early and advanced lesions of 6 patients exhibiting acneform eruptions due to corticotropin and from similar lesions of 15 patients with acne vulgaris. The clinical features of the two groups are summarized in Tables 2 and 3. RESULTS A comparison of the microscopic findings is listed in Table 4. In summary, there are similarities in the development of the two References 1. References 3 and 4. 2. References 3 and 5. 3. References 10 and 11. 4. Allen, A. C.: The Skin: A Clinicopathologic Treatise , St. Louis, C. V. Mosby Company, 1954, pp. 136, 546, 547. 5. Rothman, S.: Physiology and Biochemistry of the Skin , Chicago, University of Chicago Press, 1954, Chap. 12 , Sebaceous Gland Excretion, Pt. (6) , Endocrine Influences, pp. 297-305. 6. Ebling, F. J.: Sebaceous Glands: I. The Effect of Sex Hormones on the Sebaceous Glands of the Female Albino Rat , J. Endocrinol. 5:297, 1948.Crossref 7. Ebling, F. J.: Sebaceous Glands: 2. Changes in Sebaceous Glands Following Implantation of Oestradiol Benzoate in Female Albino Rat , J. Endocrinol. 7:288, 1951.Crossref 8. Hamilton, J. B., and Montagna, W.: The Sebaceous Glands of the Hamster: Morphological Effects of Androgens on Integumentary Structures , Am. J. Anat. 86:191, 1950.Crossref 9. Reis, F., and Gellis, S.: Effects Produced on the Pilosebaceous System and the Adrenals of the Rabbit by the Inunction of Sex Hormones , J. Invest. Dermat. 12:159, 1949. 10. Rony, H. R., and Zakon, S. J.: Effect of Androgens on the Sebaceous Glands of Human Skin , Arch. Dermat. & Syph. 48:601, 1943. 11. Haskin, D.; Lasher, N., and Rothman, S.: Some Effects of ACTH, Cortisone, Progesterone and Testosterone on Sebaceous Glands in the White Rat , J. Invest. Dermat. 20:207, 1953. 12. Aron-Brunetiere, R.: Attempt at Physiopathological Explanation of Seborrhoea and Acne Vulgaris , Brit. J. Dermat. 65:157, 1953. 13. Ketron, L. W.: The Acne Bacillus , Arch. Dermat. & Syph. 15:568, 1927. 14. Ketron, L. W.: The Relation of the Acne Bacillus to Acne Vulgaris , South. M. J. 21:368, 1928. 15. Ketron, L. W., and Burkey, E. L.: The Cultural Requirements of the Acne Bacillus , Arch. Dermat. & Syph. 11:354, 1925. 16. Ketron, L. W., and Brown, J. H.: The Acne Bacillus: Experimental Observations on Its Pathogenicity for Animals and Man , Arch. Dermat. & Syph. 20:835, 1929. 17. Unna, P. G.: The Histopathology of the Diseases of the Skin , translated by N. Walker, New York, Macmillan & Co., 1896, p. 357.
A.M.A. Archives of Dermatology – American Medical Association
Published: Feb 1, 1956