Abstract ACINIC CELL carcinoma is a relatively rare tumor of the salivary glands, constituting from 2.3% to 7.7% of major salivary gland tumors1-4 and 12% of all malignant tumors of the major salivary glands.5 It appears to arise from the serous acinic portion of the glands, hence it is also called clear cell carcinoma or serous cell adenocarcinoma.1-3,6,7 However, Bhaskar8 considers the primary source of acinic cell carcinoma to be the ductal epithelium, which is pluripotent, rather than the acinic cells. According to Godwin et al,2 all the acinic cell tumors of the major salivary glands so far reported have arisen in the parotid gland, the serous salivary gland. These tumors account for 15% to 17% of all malignant lesions of the parotid.3,9 Submandibular gland involvement of this tumor is rare.6,10 However, Shimada4 found in Japan that among seven cases of acinic cell References 1. Foote, F.W., Jr., and Frazell, E.L.: Tumors of the Major Salivary Glands , Cancer 6:1065-1133, 1953.Crossref 2. Godwin, J.T.; Foote, F.W.; and Frazell, E.L.: Acinic Cell Adenocarcinoma of the Parotid Gland , Amer J Path 30:465-478. 1954. 3. Grage, T.B.; Lober, P.H.; and Arhelger, S.W.: Acinic Cell Carcinoma of the Parotid Gland , Amer J Surg 102:765-768, 1961.Crossref 4. Shimada, Y.: On Histogenesis of the So-Called Mixed Tumors of the Salivary Gland Type: A Comparative Study of Various Salivary Gland Tumors , J Jap Soc Path 44:243-266, 1955. 5. Grage, T.B., and Lober, P.H.: Malignant Tumor of the Major Salivary Gland , Surgery 52:284-294, 1962. 6. Fox, N.M., Jr.; Remine, W.H.; and Woolner, L.B.: Acinic Cell Carcinoma of the Major Salivary Glands , Amer J Surg 106:860-867, 1963.Crossref 7. Rivlin, R.S.: Acinic Cell Adenocarcinoma of the Parotid Gland , Amer J Surg 100:639-642, 1960.Crossref 8. Bhaskar, S.N.: Acinic Cell Carcinoma of Salivary Gland , Oral Surg 17:62-74, 1964.Crossref 9. Beahrs, O.H., et al: Surgical Management of Parotid Lesions: Review of 760 Cases , Arch Surg 80:890-904, 1960.Crossref 10. Kauffman, S.L., and Stout, A.P.: Tumor of the Major Salivary Glands in Children , Cancer 16:1317-1331, 1963.Crossref 11. Abram, A.M., et al: Acinic Cell Adenocarcinoma of the Major Salivary Glands: A Clinicopathologic Study of 77 Cases , Cancer 18:1145-1162, 1965.Crossref 12. Gorlin, R.J., and Chaudhry, A.: Acinic Cell Tumor of the Major and Minor Salivary Glands , J Oral Surg 15:304-306, 1957.Crossref 13. Burbank, P.M.; Dockerty, M.B.; and Devine, K.D.: Clinical Pathologic Study of 43 Cases of Glandular Tumors of the Tongue , Surg Gynec Obstet 109:573-582, 1959. 14. Chaudry, A.P.; Vickers, R.A.; and Gorlin, R.J.: Intra-Oral Minor Salivary Gland Tumors , Oral Surg 14:1194-1226, 1961.Crossref 15. Fine, G.; Marshall, R.O.; and Horn, R.C.: Tumor of Major Salivary Gland , Cancer 13:653-669, 1960.Crossref 16. Sikorowa, L.: Adenocarcinoma Acinosum Glandulae Salivaris, Nowotwory 12:179-190, 1962.
Archives of Otolaryngology – American Medical Association
Published: Feb 1, 1968
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