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Acid-Base Disturbances in Pulmonary Edema

Acid-Base Disturbances in Pulmonary Edema Abstract CHANGES of the acid-base equilibrium in frank pulmonary edema have been studied only recently by Anthonisen and Smith,1 who reported values up to 120 mm Hg of arterial carbon dioxide pressure (Pco2) in four cases of pulmonary edema. In the present paper we are reporting the values of the pH, Pco2, HCO3-, oxygen pressure (Po2), lactate, and pyruvate concentration in the arterial blood of six patients with severe pulmonary edema before and after treatment. These results are compared with those observed in congestive heart failure, in chronic cor pulmonale, and hypercapnic coma. Material and Methods Arterial blood samples were obtained by percutaneous puncture of the femoral or brachial arteries with a 20 gauge needle attached to a heparinized syringe. For the lactate and pyruvate determination, 8 ml of a 10 ml blood sample was immediately deproteinized with 6% perchloric acid added in a 1:1 ratio. References 1. Anthonisen, U.R., and Smith, H.J.: Respiratory Acidosis as a Consequence of Pulmonary Edema , Ann Intern Med 62:993-999, 1965.Crossref 2. Scholz, R., et al: Uber die Wirkung von Nystatin auf Bäckerhefe , Biochem Z 331:71-86, 1959. 3. Segal, S.; Blair, A.E.; and Wyngaarden, G.B.: An Enzymatic Spectrophotometric Method for the Determination of Pyruvic Acid in Blood , J Lab Clin Med 48:137-143, 1956. 4. Siggaard-Andersen, O.: The Acid-Base Status of the Blood , Copenhagen: Munksgaard, 1965. 5. Eichenholz, A., et al: Primary Hypocapnia: A Cause of Metabolic Acidosis , J Appl Physiol 17: 283-288, 1962. 6. Refsum, H.E.: Acid-Base Status in Patients With Chronic Hypercapnia and Hypoxaemia , Clin Sci 27:407-415, 1964. 7. Huckabee, W.E.: Metabolic Consequences of Chronic Hypoxia , Ann NY Acad Sci 121:723-730, 1965.Crossref 8. Eldridge, F.: Blood Lactate and Pyruvate in Pulmonary Insufficiency , New Eng J Med 274: 878-883, 1965.Crossref 9. Hurtado, A.: "Animals in High Altitudes: Resident Man," in Dill, D.B. (ed.): Handbook of Physiology, Adaptation to the Environment , Washington, DC: American Physiological Society, 1964, pp 843-860. 10. Huckabee, W.E.: Lactic Acidosis , Amer J Cardiol 12:663-666, 1963.Crossref 11. Scheuer, J., and Berry, M.N.: Splanchnic Lactic Acid Production During Hyperventilation and Shock , J Clin Invest 45:1069, 1966. 12. Stewart, J.S.; Stewart, W.K.; and Gillies, H.G.: Cardiac Arrest and Acidosis , Lancet 2: 964-967, 1962.Crossref 13. Neaverson, M.A.: Metabolic Acidosis in Acute Myocardial Infarction , Brit Med J 2:383-385, 1966.Crossref 14. Vogel, J.H.K., and Blount, S.G., Jr.: The Role of Hydrogen Ion Concentration in the Regulation of Pulmonary Arterial Pressure , Circulation 32:788-796, 1965.Crossref 15. Rudolph, A.M., and Yuan, S.: Response of the Pulmonary Vasculature to Hypoxia and H+Ion Concentration Changes , J Clin Invest 45:399-411, 1966.Crossref 16. Lloyd, T.C., Jr.: Influence of Blood pH on Hypoxic Pulmonary Vasoconstriction , J Appl Physiol 21:358-364, 1966. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Acid-Base Disturbances in Pulmonary Edema

Archives of Internal Medicine , Volume 120 (3) – Sep 1, 1967

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Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1967.00300030049009
Publisher site
See Article on Publisher Site

Abstract

Abstract CHANGES of the acid-base equilibrium in frank pulmonary edema have been studied only recently by Anthonisen and Smith,1 who reported values up to 120 mm Hg of arterial carbon dioxide pressure (Pco2) in four cases of pulmonary edema. In the present paper we are reporting the values of the pH, Pco2, HCO3-, oxygen pressure (Po2), lactate, and pyruvate concentration in the arterial blood of six patients with severe pulmonary edema before and after treatment. These results are compared with those observed in congestive heart failure, in chronic cor pulmonale, and hypercapnic coma. Material and Methods Arterial blood samples were obtained by percutaneous puncture of the femoral or brachial arteries with a 20 gauge needle attached to a heparinized syringe. For the lactate and pyruvate determination, 8 ml of a 10 ml blood sample was immediately deproteinized with 6% perchloric acid added in a 1:1 ratio. References 1. Anthonisen, U.R., and Smith, H.J.: Respiratory Acidosis as a Consequence of Pulmonary Edema , Ann Intern Med 62:993-999, 1965.Crossref 2. Scholz, R., et al: Uber die Wirkung von Nystatin auf Bäckerhefe , Biochem Z 331:71-86, 1959. 3. Segal, S.; Blair, A.E.; and Wyngaarden, G.B.: An Enzymatic Spectrophotometric Method for the Determination of Pyruvic Acid in Blood , J Lab Clin Med 48:137-143, 1956. 4. Siggaard-Andersen, O.: The Acid-Base Status of the Blood , Copenhagen: Munksgaard, 1965. 5. Eichenholz, A., et al: Primary Hypocapnia: A Cause of Metabolic Acidosis , J Appl Physiol 17: 283-288, 1962. 6. Refsum, H.E.: Acid-Base Status in Patients With Chronic Hypercapnia and Hypoxaemia , Clin Sci 27:407-415, 1964. 7. Huckabee, W.E.: Metabolic Consequences of Chronic Hypoxia , Ann NY Acad Sci 121:723-730, 1965.Crossref 8. Eldridge, F.: Blood Lactate and Pyruvate in Pulmonary Insufficiency , New Eng J Med 274: 878-883, 1965.Crossref 9. Hurtado, A.: "Animals in High Altitudes: Resident Man," in Dill, D.B. (ed.): Handbook of Physiology, Adaptation to the Environment , Washington, DC: American Physiological Society, 1964, pp 843-860. 10. Huckabee, W.E.: Lactic Acidosis , Amer J Cardiol 12:663-666, 1963.Crossref 11. Scheuer, J., and Berry, M.N.: Splanchnic Lactic Acid Production During Hyperventilation and Shock , J Clin Invest 45:1069, 1966. 12. Stewart, J.S.; Stewart, W.K.; and Gillies, H.G.: Cardiac Arrest and Acidosis , Lancet 2: 964-967, 1962.Crossref 13. Neaverson, M.A.: Metabolic Acidosis in Acute Myocardial Infarction , Brit Med J 2:383-385, 1966.Crossref 14. Vogel, J.H.K., and Blount, S.G., Jr.: The Role of Hydrogen Ion Concentration in the Regulation of Pulmonary Arterial Pressure , Circulation 32:788-796, 1965.Crossref 15. Rudolph, A.M., and Yuan, S.: Response of the Pulmonary Vasculature to Hypoxia and H+Ion Concentration Changes , J Clin Invest 45:399-411, 1966.Crossref 16. Lloyd, T.C., Jr.: Influence of Blood pH on Hypoxic Pulmonary Vasoconstriction , J Appl Physiol 21:358-364, 1966.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Sep 1, 1967

References