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/lp/american-medical-association/acid-base-changes-during-lidocaine-induced-seizures-in-macaca-mulatta-ByAcX2bfAI
- Publisher
- American Medical Association
- Copyright
- Copyright © 1969 American Medical Association. All Rights Reserved.
- ISSN
- 0003-9942
- eISSN
- 1538-3687
- DOI
- 10.1001/archneur.1969.00480100082012
- Publisher site
- See Article on Publisher Site
Abstract
Abstract THE central nervous system (CNS) effects of lidocaine have been studied in both animals and man. It has been shown that an inverse relationship exists between the dose of lidocaine required to produce seizures and the arterial carbon dioxide partial pressure (PaCO2).1,2 The CNS responses to local anesthetics during nonrespiratory disturbances of acid-base balance, however, are less well documented. In this regard recent studies may be of interest, namely that a significant metabolic acidosis may occur in conjunction with electroshock or pentylenetetrazol induced seizures.3,4 The present study was undertaken in unanesthetized rhesus monkeys to evaluate lidocaine seizure threshold and acid-base equilibrium. The relationship of these factors as well as the accompanying behavioral and electrical changes was also evaluated. In contrast to most previous studies of local anesthetic drug tolerance arterial plasma lidocaine concentration was measured in addition to the calculation of seizure dosage on the basis References 1. de Jong, R.H.; Wagman, I.H.; and Prince, D.A.: Effect of Carbon Dioxide on the Cortical Seizure Threshold to Lidocaine , Exp Neurol 17:221-232 ( (Feb) ) 1967.Crossref 2. Englesson, S.; Paymaster, N.J.; and Hill, T.R.: Electrical Seizure Activity Produced by Xylocaine and Citanest , Acta Anaesth Scand , (suppl 16) , pp 47-50, 1965. 3. Hamilton, R.W., Jr., and Schoolman, A.: Acid Base Changes in Cats Following Experimental Epileptic Seizures , Neurology 15:444-448 ( (May) ) 1965.Crossref 4. Beresford, H.R.; Posner, J.B.; and Plum, F.: Changes in Brain Lactate During Experimental Seizures , Neurology 18:283 ( (March) ) 1968. 5. Wagman, I.H.; de Jong, R.H.; and Prince, D.A.: Effects of Lidocaine on Spontaneous Cortical and Subcortical Electrical Activity: Production of Seizure Discharges , Arch Neurol 18:277-290 ( (March) ) 1968.Crossref 6. Sung, C., and Truant, A.P.: The Physiological Disposition of Lidocaine and Its Comparison in Some Respects With Procaine , J Pharmacol Exp Ther 112:432-443 ( (Dec) ) 1954. 7. Andersen, O.S., and Engel, K.: A New Acid Base Nomogram , Scand J Clin Lab Invest 12:177-186, 1960.Crossref 8. Wagman, I.H.; de Jong, R.H.; and Prince, D.A.: Effects of Lidocaine on the Central Nervous System , Anesthesiology 28:155-172 ( (Jan) ) 1967.Crossref 9. Foldes, F.F., et al: Comparison of Toxicity of Intravenously Given Local Anesthetic Agents in Man , JAMA 172:1493-1498 ( (April 2) ) 1960.Crossref 10. Usubiaga, J.E., et al: Local Anesthetic-Induced Convulsions in Man , Anesth Analg 45:611-620 ( (Sept) ) 1966.Crossref 11. Kurosawa, M., et al: Cardiovascular Changes During Electroconvulsive Therapy (Japanese) , Therapeutics 21:1047-1057 ( (Sept) ) 1957. 12. Dusser De Barenne, J.G.; McCulloch, W.S.; and Nims, L.F.: Functional Activity and pH of the Cerebral Cortex , J Cell Comp Physiol 10:277-289 ( (Oct) ) 1937.Crossref 13. Ward, A.A., Jr., " Epilepsy ," in Pfeiffer, C.C., et al (eds.): International Review ofNeurobiology , New York: Academic Press, Inc., 1961, pp 137-186. 14. Arseni, C.; Stoica, I.; and Servanescu, T.: Electroclinical Investigations on the Role of Proprioceptive Stimuli in the Onset and Arrest of Convulsive Epileptic Paroxysms , Epilepsia 8:162-170 ( (Sept) ) 1967.Crossref 15. Moore, D.C., and Bridenbaugh, D.: Oxygen: The Antidote for Systemic Toxic Reaction From Local Anesthetic Drugs , JAMA 174:842-847 ( (Oct 15) ) 1960.Crossref
Journal
Archives of Neurology – American Medical Association
Published: Apr 1, 1969
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