Abstract THE central nervous system (CNS) effects of lidocaine have been studied in both animals and man. It has been shown that an inverse relationship exists between the dose of lidocaine required to produce seizures and the arterial carbon dioxide partial pressure (PaCO2).1,2 The CNS responses to local anesthetics during nonrespiratory disturbances of acid-base balance, however, are less well documented. In this regard recent studies may be of interest, namely that a significant metabolic acidosis may occur in conjunction with electroshock or pentylenetetrazol induced seizures.3,4 The present study was undertaken in unanesthetized rhesus monkeys to evaluate lidocaine seizure threshold and acid-base equilibrium. The relationship of these factors as well as the accompanying behavioral and electrical changes was also evaluated. In contrast to most previous studies of local anesthetic drug tolerance arterial plasma lidocaine concentration was measured in addition to the calculation of seizure dosage on the basis References 1. de Jong, R.H.; Wagman, I.H.; and Prince, D.A.: Effect of Carbon Dioxide on the Cortical Seizure Threshold to Lidocaine , Exp Neurol 17:221-232 ( (Feb) ) 1967.Crossref 2. Englesson, S.; Paymaster, N.J.; and Hill, T.R.: Electrical Seizure Activity Produced by Xylocaine and Citanest , Acta Anaesth Scand , (suppl 16) , pp 47-50, 1965. 3. Hamilton, R.W., Jr., and Schoolman, A.: Acid Base Changes in Cats Following Experimental Epileptic Seizures , Neurology 15:444-448 ( (May) ) 1965.Crossref 4. Beresford, H.R.; Posner, J.B.; and Plum, F.: Changes in Brain Lactate During Experimental Seizures , Neurology 18:283 ( (March) ) 1968. 5. Wagman, I.H.; de Jong, R.H.; and Prince, D.A.: Effects of Lidocaine on Spontaneous Cortical and Subcortical Electrical Activity: Production of Seizure Discharges , Arch Neurol 18:277-290 ( (March) ) 1968.Crossref 6. Sung, C., and Truant, A.P.: The Physiological Disposition of Lidocaine and Its Comparison in Some Respects With Procaine , J Pharmacol Exp Ther 112:432-443 ( (Dec) ) 1954. 7. Andersen, O.S., and Engel, K.: A New Acid Base Nomogram , Scand J Clin Lab Invest 12:177-186, 1960.Crossref 8. Wagman, I.H.; de Jong, R.H.; and Prince, D.A.: Effects of Lidocaine on the Central Nervous System , Anesthesiology 28:155-172 ( (Jan) ) 1967.Crossref 9. Foldes, F.F., et al: Comparison of Toxicity of Intravenously Given Local Anesthetic Agents in Man , JAMA 172:1493-1498 ( (April 2) ) 1960.Crossref 10. Usubiaga, J.E., et al: Local Anesthetic-Induced Convulsions in Man , Anesth Analg 45:611-620 ( (Sept) ) 1966.Crossref 11. Kurosawa, M., et al: Cardiovascular Changes During Electroconvulsive Therapy (Japanese) , Therapeutics 21:1047-1057 ( (Sept) ) 1957. 12. Dusser De Barenne, J.G.; McCulloch, W.S.; and Nims, L.F.: Functional Activity and pH of the Cerebral Cortex , J Cell Comp Physiol 10:277-289 ( (Oct) ) 1937.Crossref 13. Ward, A.A., Jr., " Epilepsy ," in Pfeiffer, C.C., et al (eds.): International Review ofNeurobiology , New York: Academic Press, Inc., 1961, pp 137-186. 14. Arseni, C.; Stoica, I.; and Servanescu, T.: Electroclinical Investigations on the Role of Proprioceptive Stimuli in the Onset and Arrest of Convulsive Epileptic Paroxysms , Epilepsia 8:162-170 ( (Sept) ) 1967.Crossref 15. Moore, D.C., and Bridenbaugh, D.: Oxygen: The Antidote for Systemic Toxic Reaction From Local Anesthetic Drugs , JAMA 174:842-847 ( (Oct 15) ) 1960.Crossref
Archives of Neurology – American Medical Association
Published: Apr 1, 1969
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera