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ACETYLSALICYLIC ACID POISONING

ACETYLSALICYLIC ACID POISONING Acetylsalicylic acid ("aspirin") poisoning appears to occur infrequently. This is evidenced by the fact that we were able to find reports of only 7 fatalities due to acetylsalicylic acid in the American literature,1 2 of which were due to hypersensitivity. Poisoning by this drug appears to be commoner in Europe, especially England, as indicated by the reports of Balazs2 and numerous British authors.3 We wish to record another fatal case and to focus attention on the fact that acetylsalicylic acid poisoning may be overlooked because of its mimicry of other toxic states. This fact, plus the close similarity between acetylsalicylic acid and sodium salicylate, the latter now being used in massive doses intravenously for the treatment of rheumatic fever, as suggested by Coburn,4 requires some caution in the use of these drugs.5 Space does not permit a full consideration of the pharmacologic, toxicologic and pathologic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

ACETYLSALICYLIC ACID POISONING

KRASNOFF, SIDNEY O.; BERNSTEIN, MITCHELL
JAMA , Volume 135 (11) – Nov 15, 1947
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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1947 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1947.62890110001008
Publisher site
See Article on Publisher Site

Abstract

Acetylsalicylic acid ("aspirin") poisoning appears to occur infrequently. This is evidenced by the fact that we were able to find reports of only 7 fatalities due to acetylsalicylic acid in the American literature,1 2 of which were due to hypersensitivity. Poisoning by this drug appears to be commoner in Europe, especially England, as indicated by the reports of Balazs2 and numerous British authors.3 We wish to record another fatal case and to focus attention on the fact that acetylsalicylic acid poisoning may be overlooked because of its mimicry of other toxic states. This fact, plus the close similarity between acetylsalicylic acid and sodium salicylate, the latter now being used in massive doses intravenously for the treatment of rheumatic fever, as suggested by Coburn,4 requires some caution in the use of these drugs.5 Space does not permit a full consideration of the pharmacologic, toxicologic and pathologic

Journal

JAMA – American Medical Association

Published: Nov 15, 1947

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