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Acetophenetidin: A Critical Bibliographic Review

Acetophenetidin: A Critical Bibliographic Review This book presents a critical review of the literature on the well-known analgesic-antipyretic agent acetophenetidin and its major metabolite N-acetyl-p-aminophenol (p-hydroxyacetanilid), to which the nonproprietary names acetaminophen and paracetamol have been applied. The book includes comments by the author as well as abstracts from the literature and from unpublished data. The main text covers the drug's history, chemistry, fate and metabolism in the body, antipyretic and analgesic actions, other therapeutic uses, effects on blood and other tissues, toxicology, tolerance, and habituation, and a summary. The bibliography and a general index appear at the end of the book. In addition to reviewing data pertaining only to acetophenetidin, the literature abstracted also includes studies of its comparative and/or combined action with such other drugs as aminopyrine, antipyrine, allylbarbituric acid, amobarbital, aspirin, salicylamide, and neocinchophen. This monograph should be of special interest and use to pharmacologists and clinical investigators as http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Acetophenetidin: A Critical Bibliographic Review

JAMA , Volume 169 (10) – Mar 7, 1959

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Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1959.03000270124030
Publisher site
See Article on Publisher Site

Abstract

This book presents a critical review of the literature on the well-known analgesic-antipyretic agent acetophenetidin and its major metabolite N-acetyl-p-aminophenol (p-hydroxyacetanilid), to which the nonproprietary names acetaminophen and paracetamol have been applied. The book includes comments by the author as well as abstracts from the literature and from unpublished data. The main text covers the drug's history, chemistry, fate and metabolism in the body, antipyretic and analgesic actions, other therapeutic uses, effects on blood and other tissues, toxicology, tolerance, and habituation, and a summary. The bibliography and a general index appear at the end of the book. In addition to reviewing data pertaining only to acetophenetidin, the literature abstracted also includes studies of its comparative and/or combined action with such other drugs as aminopyrine, antipyrine, allylbarbituric acid, amobarbital, aspirin, salicylamide, and neocinchophen. This monograph should be of special interest and use to pharmacologists and clinical investigators as

Journal

JAMAAmerican Medical Association

Published: Mar 7, 1959

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