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Abstract At the meeting of the Vienese Dermatological Society in November 1927 one of us (M. O.)1 presented a patient with pemphigus serpiginosus who had been treated with acetarsone. This was a 58 year old woman who had an eruption of three and one-half months' duration. Acetarsone and exposure to ultraviolet radiation from a quartz mercury vapor lamp caused improvement with a tendency toward epithelization. After this demonstration several cases of eruptions of the pemphigus group were published in which the disease was favorably influenced by acetarsone. Kromayer2 in 1929 reported 6 cases of pemphigus, including 2 in which it was severe, in which the eruption was healed. The drug was administered over a long period with intermissions. In 1 case 600 tablets were given. All the patients improved so that they were able to return to their former occupations. Relapses in the form of blisters and in 1 References 1. Oppenheim, M.: Pemphigus chronicus serpiginosus , Zentralbl. f. Haut- u. Geschlechtskr. 26:350, 1927. 2. Kromayer, E.: Sechs durch Spirozid geheilte Pemphigusfälle , Deutsche med. Wchnschr. 55:229-230, 1929.Crossref 3. Vamos, L.: Pemphigus vegetans , Zentralbl. f. Haut- u. Geschlechtskr. 32: 791, 1929 4. Mit Spirozid geheilter Pemphigus , Vamos Zentralbl. f. Haut- u. Geschlechtskr. 34:22, 1930. 5. Brann: Zwei Fälle Pemphigus vulgaris , Zentralbl. f. Haut- u. Geschlechtskr. 32:557, 1929. 6. Langer, E.: Pemphigus vulgaris: II. Pemphigus vegetans , Zentralbl. f. Haut- u. Geschlechtskr. 33:301, 1930. 7. Freund and Mueller: Pemphigus vulgaris , Zentralbl. f. Haut- u. Geschlechtskr. 34:531, 1930. 8. Footnote deleted on proof. 9. Oppenheim, M.: Ueber die Verwendung des Spirocids beim Pemphigus vulgaris chronicus und vegetans nebst Bemerkungen zur Spirocidtherapie , Dermat. Wchnschr. 91:1855, 1930. 10. Rothman, S., in discussion on Rattner, H., and Cornbleet, T.: A Case for Diagnosis (Bullous Eruption) , Arch. Dermat. & Syph. 43:1061 ( (June) ) 1941. 11. Oppenheim, M., and Cohen, D.: Primary Lesions of Pemphigus Vulgaris , Arch. Dermat. & Syph. 46:201 ( (Aug.) ) 1942. 12. Ebert, M. H.: Pemphigus Vulgaris Treated with Acetarsone , Arch. Dermat. & Syph. 45:796 ( (April) ) 1942. 13. Zakon, S. J.: Pemphigus Erythematodes (Senear-Usher) , Arch. Dermat. & Syph. 45:791 ( (April) ) 1942.
Archives of Dermatology and Syphilology – American Medical Association
Published: Jan 1, 1943
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