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ACCURATE PREGNANCY TESTING IN TRANQUILIZED PATIENTS

ACCURATE PREGNANCY TESTING IN TRANQUILIZED PATIENTS The reported occurrence of false-positive results of pregnancy tests in patients taking certain tranquilizers has been investigated. The test in question involved the intra-abdominal injection of a urine concentrate from the patient into male frogs, and the production of spermaturia constituted a positive result. The 50 psychiatric patients in the present study were all receiving promazine, prochlorperazine, or perphenazine daily in substantial doses. Samples of serum were obtained for use in place of urine concentrates. Hyaluronidase was injected with the serum to facilitate adsorption. Two frogs weighing from 25 to 50 Gm. were used for each of the 50 tests. There was no evidence that the test carried out in this way would give false-positive results in patients receiving tranquilizers of the phenothiazine group. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

ACCURATE PREGNANCY TESTING IN TRANQUILIZED PATIENTS

JAMA , Volume 170 (16) – Aug 15, 1959

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Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1959.03010160006002
Publisher site
See Article on Publisher Site

Abstract

The reported occurrence of false-positive results of pregnancy tests in patients taking certain tranquilizers has been investigated. The test in question involved the intra-abdominal injection of a urine concentrate from the patient into male frogs, and the production of spermaturia constituted a positive result. The 50 psychiatric patients in the present study were all receiving promazine, prochlorperazine, or perphenazine daily in substantial doses. Samples of serum were obtained for use in place of urine concentrates. Hyaluronidase was injected with the serum to facilitate adsorption. Two frogs weighing from 25 to 50 Gm. were used for each of the 50 tests. There was no evidence that the test carried out in this way would give false-positive results in patients receiving tranquilizers of the phenothiazine group.

Journal

JAMAAmerican Medical Association

Published: Aug 15, 1959

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