Key PointsQuestionIs plus disease in retinopathy of prematurity more reliably and accurately diagnosed by eye-based assessment of overall retinal appearance or by quadrant-based assessment combining grades of individual quadrants? FindingsIn this multicenter cohort study including 141 preterm infants, graders diagnosed 197 eyes by reviewing the entire wide-angle retinal images (eye-based diagnosis; plus vs not plus) and subsequently by reviewing each of the cropped quadrant images (plus vs not plus), which was combined into a quadrant-based diagnosis. Graders had lower intragrader and intergrader agreement and agreement with reference standard diagnosis using quadrant-based diagnosis than eye-based diagnosis. MeaningEye-based diagnosis may have advantages over quadrant-based diagnosis regarding reliability and accuracy.
JAMA Ophthalmology – American Medical Association
Published: Jun 26, 2018
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