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Acanthamoeba Keratitis Possibly Acquired From a Hot Tub

Acanthamoeba Keratitis Possibly Acquired From a Hot Tub Abstract • An irritated left eye followed by a geographic epithelial corneal defect developed in a 42-year-old man. Disciform edema developed in the cornea, and the lesion progressed to a ring-shaped abscess. The lesion failed to respond to medical therapy. After two penetrating keratoplasties, histopathologic examination and electron microscopic studies established the diagnosis of Acanthamoeba keratitis. Subsequent cultures and immunofluorescent studies identified the organism as Acanthamoeba castellani. Following treatment with antibiotics and corneal cryotherapy, there has been no evidence of recurrence. Morphologically and immunologically identical amebae were also cultured from the patient's hot tub and surrounding garden. References 1. Naginton J, Watson PG, Playfair TJ, et al: Amoebic infection of the eye . Lancet 1974;2:1547-1550. 2. Jones DB, Visvesvara GS, Robinson NM: Acanthamoeba polyphaga keratitis and Acanthamoeba uveitis associated with fatal meningoencephalitis . Trans Ophthalmol Soc UK 1975;95:221-231. 3. Lund OE, Stefani FH, Dechant W: Amoebic keratitis: A clinicopathologic case report . Br J Ophthalmol 1978;62:373-375.Crossref 4. Ma P, Juechter KB: The sixth case of Acanthamoeba infection of the eye. Presented at the 79th annual meeting of the American Society of Microbiology, Los Angeles, May 4, 1979. 5. Key SN, Green WR, Willaert E: Keratitis due to Acanthamoeba castellani: A clinicopathologic case report . Arch Ophthalmol 1980;98:475-479.Crossref 6. Bos HJ, Volker-Dieben HJ, Kok-Van Alphen CC: A case of Acanthamoeba keratitis in the Netherlands . Trans R Soc Trop Med Hyg 1981; 75:86-91.Crossref 7. Ma P, Willaert E, Juechter KB, et al: A case of keratitis due to Acanthamoeba in New York, New York and features of ten cases . J Infect Dis 1981;143:662-667.Crossref 8. Hamburg A, DeJonckheere JF: Amoebic keratitis . Ophthalmologica 1980;181:74-80.Crossref 9. Cleveland PH, Richman DD, Redfield DC, et al: Enzyme immunofiltration technique for a rapid diagnosis of herpes simplex virus eye infections in a rabbit model . J Clin Microbiol 1982; 16:676-685. 10. Visvesvara GS: Free living pathogenic amoebae , in Lennette EH, Balows A, Hausler WJ, et al (eds): Manual of Clinical Microbiology . Washington, DC, American Society for Microbiology, 1980, pp 704-708. 11. Griffin J: Temperature tolerance of pathogenic and non-pathogenic free living amoeba . Science 1972;17:869-870.Crossref 12. Neff RJ, Ray SA, Benton WF, et al: Induction of synchronous encystment (differentiates) in Acanthamoeba species , Methods in Cell Physiology . New York, Academic Press Inc, 1964, vol 1, pp 55-83. 13. Cerva L: Studies of limax amoeba in a swimming pool . Hydrobiologia 1971;38:141-161.Crossref 14. Visvesvara GS, Jones DM, Robinson NM: Isolation, identification and biological characterization of Acanthamoeba polyphaga from a human eye . Am J Trop Med Hyg 1975;24:785-790. 15. Willaert E, Stevens AR: Indirect immunofluorescent identification of Acanthamoeba causing meningoencephalitis . Pathol Biol 1976;24:545-547. 16. Bowers B, Korn ED: The fine structure of Acanthamoeba castellani: I. The trophozoite . J Cell Biol 1968;39:95-111.Crossref 17. Bowers B, Korn ED: The fine structure of Acanthamoeba castellani: II. Encystment . J Cell Biol 1968;41:786-805.Crossref 18. Font RL, Taper MJ, Robinson NM, et al: An animal model of Acanthamoeba keratitis: Further studies with emphasis on early phase of destruction of trophozoites . Invest Ophthalmol Vis Sci Suppl 1982;21:163. 19. Naginton J, Richards JE: Chemotherapeutic compounds and Acanthamoebae from eye infections . J Clin Pathol 1976;29:648-651.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1984.01040030563018
Publisher site
See Article on Publisher Site

Abstract

Abstract • An irritated left eye followed by a geographic epithelial corneal defect developed in a 42-year-old man. Disciform edema developed in the cornea, and the lesion progressed to a ring-shaped abscess. The lesion failed to respond to medical therapy. After two penetrating keratoplasties, histopathologic examination and electron microscopic studies established the diagnosis of Acanthamoeba keratitis. Subsequent cultures and immunofluorescent studies identified the organism as Acanthamoeba castellani. Following treatment with antibiotics and corneal cryotherapy, there has been no evidence of recurrence. Morphologically and immunologically identical amebae were also cultured from the patient's hot tub and surrounding garden. References 1. Naginton J, Watson PG, Playfair TJ, et al: Amoebic infection of the eye . Lancet 1974;2:1547-1550. 2. Jones DB, Visvesvara GS, Robinson NM: Acanthamoeba polyphaga keratitis and Acanthamoeba uveitis associated with fatal meningoencephalitis . Trans Ophthalmol Soc UK 1975;95:221-231. 3. Lund OE, Stefani FH, Dechant W: Amoebic keratitis: A clinicopathologic case report . Br J Ophthalmol 1978;62:373-375.Crossref 4. Ma P, Juechter KB: The sixth case of Acanthamoeba infection of the eye. Presented at the 79th annual meeting of the American Society of Microbiology, Los Angeles, May 4, 1979. 5. Key SN, Green WR, Willaert E: Keratitis due to Acanthamoeba castellani: A clinicopathologic case report . Arch Ophthalmol 1980;98:475-479.Crossref 6. Bos HJ, Volker-Dieben HJ, Kok-Van Alphen CC: A case of Acanthamoeba keratitis in the Netherlands . Trans R Soc Trop Med Hyg 1981; 75:86-91.Crossref 7. Ma P, Willaert E, Juechter KB, et al: A case of keratitis due to Acanthamoeba in New York, New York and features of ten cases . J Infect Dis 1981;143:662-667.Crossref 8. Hamburg A, DeJonckheere JF: Amoebic keratitis . Ophthalmologica 1980;181:74-80.Crossref 9. Cleveland PH, Richman DD, Redfield DC, et al: Enzyme immunofiltration technique for a rapid diagnosis of herpes simplex virus eye infections in a rabbit model . J Clin Microbiol 1982; 16:676-685. 10. Visvesvara GS: Free living pathogenic amoebae , in Lennette EH, Balows A, Hausler WJ, et al (eds): Manual of Clinical Microbiology . Washington, DC, American Society for Microbiology, 1980, pp 704-708. 11. Griffin J: Temperature tolerance of pathogenic and non-pathogenic free living amoeba . Science 1972;17:869-870.Crossref 12. Neff RJ, Ray SA, Benton WF, et al: Induction of synchronous encystment (differentiates) in Acanthamoeba species , Methods in Cell Physiology . New York, Academic Press Inc, 1964, vol 1, pp 55-83. 13. Cerva L: Studies of limax amoeba in a swimming pool . Hydrobiologia 1971;38:141-161.Crossref 14. Visvesvara GS, Jones DM, Robinson NM: Isolation, identification and biological characterization of Acanthamoeba polyphaga from a human eye . Am J Trop Med Hyg 1975;24:785-790. 15. Willaert E, Stevens AR: Indirect immunofluorescent identification of Acanthamoeba causing meningoencephalitis . Pathol Biol 1976;24:545-547. 16. Bowers B, Korn ED: The fine structure of Acanthamoeba castellani: I. The trophozoite . J Cell Biol 1968;39:95-111.Crossref 17. Bowers B, Korn ED: The fine structure of Acanthamoeba castellani: II. Encystment . J Cell Biol 1968;41:786-805.Crossref 18. Font RL, Taper MJ, Robinson NM, et al: An animal model of Acanthamoeba keratitis: Further studies with emphasis on early phase of destruction of trophozoites . Invest Ophthalmol Vis Sci Suppl 1982;21:163. 19. Naginton J, Richards JE: Chemotherapeutic compounds and Acanthamoebae from eye infections . J Clin Pathol 1976;29:648-651.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: May 1, 1984

References