Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

ABSORPTION OF POLIOMYELITIS VIRUS BY POSSIBLY DEFICIENTLY MEDULLATED NERVES

ABSORPTION OF POLIOMYELITIS VIRUS BY POSSIBLY DEFICIENTLY MEDULLATED NERVES The dictum has been formulated that poliomyelitis virus has an almost obligate affinity for gray nerve fibers.1 When the virus is injected into medullated peripheral nerves of a normal Macaca mulatta monkey its spread is resisted, unless there has been previous manipulation whereby gray-fibered axis-cylinders have become exposed.2 Even under these conditions, the disease is difficult to produce. It may be concluded, therefore, that poliomyelitis virus has but a slight affinity for the exposed axons of peripheral medullated nerves, and, by inference, it might be deduced that its spread to the central nervous system is stopped by the myelin contained in the sheath which covers the gray fibers. This would explain why there is not in every case of poliomyelitis involvement of the vagus nerve, which is actually a bundle of well medullated connector fibers, the postganglionic unmedullated gray fibers of which are found in the walls of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

ABSORPTION OF POLIOMYELITIS VIRUS BY POSSIBLY DEFICIENTLY MEDULLATED NERVES

Loading next page...
 
/lp/american-medical-association/absorption-of-poliomyelitis-virus-by-possibly-deficiently-medullated-ewNEYyN6sn

References (2)

Publisher
American Medical Association
Copyright
Copyright © 1940 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1940.02000030080007
Publisher site
See Article on Publisher Site

Abstract

The dictum has been formulated that poliomyelitis virus has an almost obligate affinity for gray nerve fibers.1 When the virus is injected into medullated peripheral nerves of a normal Macaca mulatta monkey its spread is resisted, unless there has been previous manipulation whereby gray-fibered axis-cylinders have become exposed.2 Even under these conditions, the disease is difficult to produce. It may be concluded, therefore, that poliomyelitis virus has but a slight affinity for the exposed axons of peripheral medullated nerves, and, by inference, it might be deduced that its spread to the central nervous system is stopped by the myelin contained in the sheath which covers the gray fibers. This would explain why there is not in every case of poliomyelitis involvement of the vagus nerve, which is actually a bundle of well medullated connector fibers, the postganglionic unmedullated gray fibers of which are found in the walls of

Journal

American journal of diseases of childrenAmerican Medical Association

Published: Sep 1, 1940

There are no references for this article.