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Absorption of Glucose Solutions From the Peritoneal Cavity in Rabbits

Absorption of Glucose Solutions From the Peritoneal Cavity in Rabbits Abstract • Complications created by the long-term administration of intravenous total-bowel parenteral nutrition solutions and the observed high transfer rate of solutes across the peritoneum during long-term peritoneal dialysis suggested that glucose absorption from the peritoneal cavity could be evaluated as a technique for providing nutritional support. We performed peritoneal dialysis on 55 rabbits using dextrose solutions. Infusion every two hours with different concentrations of dextrose solutions (in 18 rabbits) showed a direct correlation of glucose absorption with the dextrose concentration in the peritoneal fluid. Varying the duration of peritoneal fluid infusion showed (in 28 rabbits) that the maximal glucose disappearance from the peritoneal cavity and the maximum increase in serum glucose occur within two hours. Varying the volume of dialysate with each exchange (in 14 rabbits) showed a direct correlation between glucose absorption and increased fluid volumes. Resection of the omentum or 40% to 60% of the small intestine (in 11 rabbits) caused only a 6.5% to 14% decrease in glucose absorption compared with normal rabbits. (Arch Surg 1984;119:1247-1251) References 1. Fonkalsrud EW, Ament ME, Berquist WE, et al: Occlusion of the vena cava in infants receiving central venous hyperalimentation . Surg Gynecol Obstet 1982;154:189-192. 2. Stephens WP, Lawler W: Thrombus formation and central venous catheters . Lancet 1982;2:664-665.Crossref 3. Philips JB III, Ruiz-Castaneda N, Setzer ES: Coronary sinus thrombosis: A central venous catheter complication . J Pediatr Surg 1981;16: 733-734.Crossref 4. Strobel CT, Byrne WJ, Fonkalsrud EW, et al: Home parenteral nutrition: Results in 34 pediatric patients . Ann Surg 1978;394-403. 5. Klein GL, Cannon RA, Diament M, et al: Infantile vitamin D-resistant rickets associated with total parenteral nutrition . AJDC 1982;136:74-76. 6. Touloukian RJ, Downing SE: Cholestasis associated with long-term parenteral hyperalimentation . Arch Surg 1973;106:58-62.Crossref 7. Wiley EL, Hutchins GM: Superior vena cava syndrome secondary to candida thrombophlebitis complicating parenteral alimentation . J Pediatr 1977;91:977-979.Crossref 8. Groff DB: Complications of intravenous hyperalimentation in new-borns and infants . J Pediatr Surg 1969;4:460-464.Crossref 9. Kulkarni PB, Dorand RD, Simmons EM: Pericardial tamponade: Complication of total parenteral nutrition . J Pediatr Surg 1981;16:735-736.Crossref 10. Franciosi RA, Ellefson RD, Ulen D, et al: Sudden unexpected death during central hyperalimentation . Pediatrics 1982;69:305-307. 11. Firor HV: Pulmonary embolization complicating total intravenous alimentation . J Pediatr Surg 1972;7:81.Crossref 12. Redline RW, Dahms BB: Malassezia pulmonary vasculitis in an infant on long-term Intralipid therapy . N Engl J Med 1981;305:1395-1398.Crossref 13. Kawarasaki H, Fujiwara T, Fonkalsrud EW: The effects of administering hyperalimentation solutions into the atrium and pulmonary artery. J Pediatr Surg, in press. 14. Baum M, Powell D, Calvins S, et al: Continuous ambulatory peritoneal dialysis in children: Comparison with hemodialysis . N Engl J Med 1982;307:1537-1542.Crossref 15. Fennell RS, Orak JK, Garin EH, et al: Continuous ambulatory peritoneal dialysis in a pediatric population . AJDC 1983;137:388-392. 16. DeSanto NG, Capidocasa G, Senatore R, et al: Glucose utilization from dialysate in patients on continuous ambulatory peritoneal dialysis (CPAD) . Int J Artif Organs 1979;2:119-124. 17. Giordano C, Capodicasa G, DeSanto NG: Artificial gut for total parenteral nutrition through the peritoneal cavity . Int J Artif Organs 1980;3:325-330. 18. DeSanto NG, Capodicasa G, Gilli G, et al: Metabolic aspects of CAPD with reference to energy-protein input and growth . Int J Pediatr Nephrol 1982;3:279-286. 19. VonBaeyer H: Adaptation of CAPD patients to the continuous peritoneal energy uptake . Kidney Int 1983;23:29-34.Crossref 20. Grodstein GP, Blumenkrantz MK, Kopple JD, et al: Glucose absorption during continuous ambulatory peritoneal dialysis . Kidney Int 1981; 19:564-567.Crossref 21. Allen L: On the penetrability of the lymphatics of the diaphragm . Anat Rec 1956;124:639-658.Crossref 22. Popovich R: Physiological transport parameters in patients . Dialysis Transpl 1978;7:823-828. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Absorption of Glucose Solutions From the Peritoneal Cavity in Rabbits

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1984.01390230019004
Publisher site
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Abstract

Abstract • Complications created by the long-term administration of intravenous total-bowel parenteral nutrition solutions and the observed high transfer rate of solutes across the peritoneum during long-term peritoneal dialysis suggested that glucose absorption from the peritoneal cavity could be evaluated as a technique for providing nutritional support. We performed peritoneal dialysis on 55 rabbits using dextrose solutions. Infusion every two hours with different concentrations of dextrose solutions (in 18 rabbits) showed a direct correlation of glucose absorption with the dextrose concentration in the peritoneal fluid. Varying the duration of peritoneal fluid infusion showed (in 28 rabbits) that the maximal glucose disappearance from the peritoneal cavity and the maximum increase in serum glucose occur within two hours. Varying the volume of dialysate with each exchange (in 14 rabbits) showed a direct correlation between glucose absorption and increased fluid volumes. Resection of the omentum or 40% to 60% of the small intestine (in 11 rabbits) caused only a 6.5% to 14% decrease in glucose absorption compared with normal rabbits. (Arch Surg 1984;119:1247-1251) References 1. Fonkalsrud EW, Ament ME, Berquist WE, et al: Occlusion of the vena cava in infants receiving central venous hyperalimentation . Surg Gynecol Obstet 1982;154:189-192. 2. Stephens WP, Lawler W: Thrombus formation and central venous catheters . Lancet 1982;2:664-665.Crossref 3. Philips JB III, Ruiz-Castaneda N, Setzer ES: Coronary sinus thrombosis: A central venous catheter complication . J Pediatr Surg 1981;16: 733-734.Crossref 4. Strobel CT, Byrne WJ, Fonkalsrud EW, et al: Home parenteral nutrition: Results in 34 pediatric patients . Ann Surg 1978;394-403. 5. Klein GL, Cannon RA, Diament M, et al: Infantile vitamin D-resistant rickets associated with total parenteral nutrition . AJDC 1982;136:74-76. 6. Touloukian RJ, Downing SE: Cholestasis associated with long-term parenteral hyperalimentation . Arch Surg 1973;106:58-62.Crossref 7. Wiley EL, Hutchins GM: Superior vena cava syndrome secondary to candida thrombophlebitis complicating parenteral alimentation . J Pediatr 1977;91:977-979.Crossref 8. Groff DB: Complications of intravenous hyperalimentation in new-borns and infants . J Pediatr Surg 1969;4:460-464.Crossref 9. Kulkarni PB, Dorand RD, Simmons EM: Pericardial tamponade: Complication of total parenteral nutrition . J Pediatr Surg 1981;16:735-736.Crossref 10. Franciosi RA, Ellefson RD, Ulen D, et al: Sudden unexpected death during central hyperalimentation . Pediatrics 1982;69:305-307. 11. Firor HV: Pulmonary embolization complicating total intravenous alimentation . J Pediatr Surg 1972;7:81.Crossref 12. Redline RW, Dahms BB: Malassezia pulmonary vasculitis in an infant on long-term Intralipid therapy . N Engl J Med 1981;305:1395-1398.Crossref 13. Kawarasaki H, Fujiwara T, Fonkalsrud EW: The effects of administering hyperalimentation solutions into the atrium and pulmonary artery. J Pediatr Surg, in press. 14. Baum M, Powell D, Calvins S, et al: Continuous ambulatory peritoneal dialysis in children: Comparison with hemodialysis . N Engl J Med 1982;307:1537-1542.Crossref 15. Fennell RS, Orak JK, Garin EH, et al: Continuous ambulatory peritoneal dialysis in a pediatric population . AJDC 1983;137:388-392. 16. DeSanto NG, Capidocasa G, Senatore R, et al: Glucose utilization from dialysate in patients on continuous ambulatory peritoneal dialysis (CPAD) . Int J Artif Organs 1979;2:119-124. 17. Giordano C, Capodicasa G, DeSanto NG: Artificial gut for total parenteral nutrition through the peritoneal cavity . Int J Artif Organs 1980;3:325-330. 18. DeSanto NG, Capodicasa G, Gilli G, et al: Metabolic aspects of CAPD with reference to energy-protein input and growth . Int J Pediatr Nephrol 1982;3:279-286. 19. VonBaeyer H: Adaptation of CAPD patients to the continuous peritoneal energy uptake . Kidney Int 1983;23:29-34.Crossref 20. Grodstein GP, Blumenkrantz MK, Kopple JD, et al: Glucose absorption during continuous ambulatory peritoneal dialysis . Kidney Int 1981; 19:564-567.Crossref 21. Allen L: On the penetrability of the lymphatics of the diaphragm . Anat Rec 1956;124:639-658.Crossref 22. Popovich R: Physiological transport parameters in patients . Dialysis Transpl 1978;7:823-828.

Journal

Archives of SurgeryAmerican Medical Association

Published: Nov 1, 1984

References