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Absence of Human T-Cell Lymphotropic Virus Genomic Determinants in Canine Mycosis Fungoides

Absence of Human T-Cell Lymphotropic Virus Genomic Determinants in Canine Mycosis Fungoides Abstract Cutaneous T-cell lymphoma (CTCL) is usually characterized by erythematous scaling patches, plaques, and tumors that can have a varied clinical course ranging from an indolent disease lasting for many years to a rapidly progressive fatal disease with extensive visceral involvement.1 Recently, we have reported that canine CTCL mimics human CTCL ultrastructurally, genetically, and immunophenotypically,2,3 and we propose that canine CTCL can be used as a model for the study of CTCL in humans.3-5 Pancake et al6 have associated human mycosis fungoides (MF) and the adult T-cell lymphoma/leukemia syndrome with human T-cell lymphotropic virus type 1 (HTLV-1). There is also a report of reverse transcriptase activity in 1 dog with CTCL, suggesting a retroviral link.4 Herein we show that there is no detectable HTLV-1 or HTLV-2n DNA in a total of 10 cases of canine CTCL by either routine Southern blot analysis or by the polymerase References 1. Winkler CF, Bunn PA Jr. Cutaneous T cell lymphoma: a review . Crit Rev Oncol Hematol. 1983;1:49-92.Crossref 2. Fivenson DP, Beck ER, Dunstan RW, Nickoloff BJ, Moore PF. Dermal dendrocytes and T cells in canine mycosis fungoides: support for an animal model of human cutaneous T cell lymphoma . Cancer . 1992;70:2091-2098.Crossref 3. Fivenson DP, Saed GM, Beck ER, Dunstan RW, Moore PF. T cell receptor gene rearrangement in canine mycosis fungoides: further support for a canine model of cutaneous T cell lymphoma . J Invest Dermatol. 1994;102:227-230.Crossref 4. Tomley FM, Armstrong SJ, Mahy BWJ, Owen LN. Reverse transcriptase activity and particles of retroviral density in cultured canine lymphosarcoma cells . Br J Cancer . 1983;47:277-284.Crossref 5. Hall WW, Liu CR, Schneewind O, et al. Deleted HTLV-I provirus in blood and cutaneous lesions of patients with mycosis fungoides . Science . 1991;253: 317-320.Crossref 6. Pancake BA, Zucker-Franklin D, Coutavas EE. The cutaneous T cell lymphoma, mycosis fungoides, is a human T cell lymphotropic virus-associated disease: a study of 50 patients . J Clin Invest. 1995;95:547-554.Crossref 7. Boni R, Daneschfar AD, Burg G, Fuchs D, Wood GS. No detection of HTLV-I proviral DNA in lesional biopsies from Swiss and German patients with cutanteous T cell lymphoma . Br J Dermatol. In press. 8. Katajima I, Yamamoto K, Sato K, et al. Detection of human T cell lymphotropic virus type I proviral DNA and its gene expression in synovial cells in chronic inflammatory arthropathy . J Clin Invest. 1991;88:1315-1322.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Absence of Human T-Cell Lymphotropic Virus Genomic Determinants in Canine Mycosis Fungoides

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Publisher
American Medical Association
Copyright
Copyright © 1996 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1996.03890310133029
Publisher site
See Article on Publisher Site

Abstract

Abstract Cutaneous T-cell lymphoma (CTCL) is usually characterized by erythematous scaling patches, plaques, and tumors that can have a varied clinical course ranging from an indolent disease lasting for many years to a rapidly progressive fatal disease with extensive visceral involvement.1 Recently, we have reported that canine CTCL mimics human CTCL ultrastructurally, genetically, and immunophenotypically,2,3 and we propose that canine CTCL can be used as a model for the study of CTCL in humans.3-5 Pancake et al6 have associated human mycosis fungoides (MF) and the adult T-cell lymphoma/leukemia syndrome with human T-cell lymphotropic virus type 1 (HTLV-1). There is also a report of reverse transcriptase activity in 1 dog with CTCL, suggesting a retroviral link.4 Herein we show that there is no detectable HTLV-1 or HTLV-2n DNA in a total of 10 cases of canine CTCL by either routine Southern blot analysis or by the polymerase References 1. Winkler CF, Bunn PA Jr. Cutaneous T cell lymphoma: a review . Crit Rev Oncol Hematol. 1983;1:49-92.Crossref 2. Fivenson DP, Beck ER, Dunstan RW, Nickoloff BJ, Moore PF. Dermal dendrocytes and T cells in canine mycosis fungoides: support for an animal model of human cutaneous T cell lymphoma . Cancer . 1992;70:2091-2098.Crossref 3. Fivenson DP, Saed GM, Beck ER, Dunstan RW, Moore PF. T cell receptor gene rearrangement in canine mycosis fungoides: further support for a canine model of cutaneous T cell lymphoma . J Invest Dermatol. 1994;102:227-230.Crossref 4. Tomley FM, Armstrong SJ, Mahy BWJ, Owen LN. Reverse transcriptase activity and particles of retroviral density in cultured canine lymphosarcoma cells . Br J Cancer . 1983;47:277-284.Crossref 5. Hall WW, Liu CR, Schneewind O, et al. Deleted HTLV-I provirus in blood and cutaneous lesions of patients with mycosis fungoides . Science . 1991;253: 317-320.Crossref 6. Pancake BA, Zucker-Franklin D, Coutavas EE. The cutaneous T cell lymphoma, mycosis fungoides, is a human T cell lymphotropic virus-associated disease: a study of 50 patients . J Clin Invest. 1995;95:547-554.Crossref 7. Boni R, Daneschfar AD, Burg G, Fuchs D, Wood GS. No detection of HTLV-I proviral DNA in lesional biopsies from Swiss and German patients with cutanteous T cell lymphoma . Br J Dermatol. In press. 8. Katajima I, Yamamoto K, Sato K, et al. Detection of human T cell lymphotropic virus type I proviral DNA and its gene expression in synovial cells in chronic inflammatory arthropathy . J Clin Invest. 1991;88:1315-1322.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Jul 1, 1996

References