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ABNORMALITIES IN THE CHEMICAL COMPOSITION OF THE SKIN SURFACE FILM IN PSORIASIS

ABNORMALITIES IN THE CHEMICAL COMPOSITION OF THE SKIN SURFACE FILM IN PSORIASIS Abstract ANALYSIS of the surface film of the uninvolved skin in psoriasis as compared with that of the skin of normal persons was undertaken on the basis of a working hypothesis which seems to be in accord with all known data on psoriasis. Psoriasis, on one hand, has features of diseases caused by micro-organisms, such as peripheral spread and central healing of the lesions with formation of annular elements and arciform edges. On the other hand, it is a familial disease with irregularly dominant mendelian inheritance.1 In the present hypothesis it is assumed that it is the susceptibility to the unknown causative organisms which is inherited. The organism is ubiquitous but only those persons who have genetically induced susceptibility will acquire lesions on contact with the organism. Thus psoriasis is not contagious though it is caused by an infective agent. The lesions of psoriasis can be cleared References 1. Hoede, K.: Umwelt und Erblichkeit bei der Entstehung der Schuppenflechte , Würzburg. Abhandl. a. d. Gesamtgeb. d. med. 27:211-254, 1931. 2. Saifer, A., and Kammerer, O. F.: Photometric Determination of Total Cholesterol in Plasma or Serum by a Modified Liebermann-Burchard Reaction , J. Biol. Chem. 164:657-677, 1946. 3. In this series cholesterol and cholesterol ester estimations were carried out according to the method of Saifer and Kammerer.2 4. Rothman, S.; Smiljanic, A. M., and Murphy, J. C.: The Nitrogenous Material on Normal Human Skin Surface , J. Invest. Dermat. 13:317-318, 1949.Crossref 5. Rothman, S., and Sullivan, M. B.: Amino-Acids on the Normal Human Skin Surface , J. Invest. Dermat. 13:319-321, 1949.Crossref 6. Koch, F. C., and Hanke, M. E.: Practical Methods in Biochemistry , ed. 4, Baltimore, Williams & Wilkins Company, 1943, p. 163. 7. Krebs, H., and Henseleit, K.: Untersuchungen über die Harnstoffbildung im Tierkörper , Klin. Wchnschr. 11:757-759 and 1137-1139, 1932Crossref 8. Ztschr. f. physiol. Chem. 210:33-66, 1932.Crossref 9. Kooyman, D. J.: LXI. Lipids of the Skin: Some Changes in the Lipids of the Epidermis During the Process of Keratinization , Arch. Dermat. & Syph. 25:444-450 ( (March) ) 1932. 10. Marchionini, A.; Manz, E., and Huss, F.: Der Cholesteringehalt der Hautoberschicht bei der Seborrhöe und bei der Psoriasis: Beiträge zur Kenntnis der pathochemischen Hautkonstitution des Status seborrhoicus , Arch. f. Dermat. u. Syph. 176:613-645, 1938. 11. Grütz, O., and Bürger, M.: Die Psoriasis als Stoffwechselproblem , Klin. Wchnschr. 12:373-379, 1933 12. Arch. f. Dermat. u. Syph. 170:143-150, 1934. 13. Incedayi, C. K., and Ottenstein, B.: Neuere Untersuchungen über die Beziehungen zwischen Psoriasis und Lipoidosen , Acta dermat.-venereol. 21:674-698, 1940. 14. Madden, J. F., and Barthell, J. H.: Liver Function in Psoriasis: Preliminary Report , J. Invest. Dermat. 9:125-130, 1947. 15. Walsh, E. N.; Clark, D. E.; Dragstedt, L. R., and Becker, S. W.: Further Observations on the Use of Lipocaic in the Treatment of Psoriasis , J. Invest. Dermat. 4:59-67, 1941. 16. Gross, P., and Kesten, B. M.: Treatment of Psoriasis with Lipotropic Substances Derived from Foodstuffs , Arch. Dermat. & Syph. 47:159-174 ( (Feb.) ) 1943. 17. Campana, C., and Gualandi, G.: Tentativo di cura della psoriasi volgare con pancreas "per os," Policlinico (sez. prat.) 54:7-10, 1947. 18. Sinclair, R. G.: Fat Metabolism , Ann. Rev. Biochem. 6:245-268, 1937. 19. McHenry, E. W., and Patterson, J. M.: Lipotropic Factors , Physiol. Rev. 24:128-167, 1944. 20. Ottolenghi-Lodigiani, F.: Studi sulla colesterina della cute umana normale e patologica: Nota II. La presenza nella cute umana del fermento esterificante la colesterina; la colesterinesterasi , Gior. ital. dermat. e. sif. 89:363-373, 1948. 21. Madden, J. F.: Histologic Studies of Uninvolved Skin of Patients with Psoriasis , Arch. Dermat. & Syph. 44:655-664 ( (Oct.) ) 1941. 22. Hier, S. W.; Cornbleet, T., and Bergheim, O.: The Amino-Acids of Human Sweat , J. Biol. Chem. 166:327-333, 1946. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology & Syphilology American Medical Association

ABNORMALITIES IN THE CHEMICAL COMPOSITION OF THE SKIN SURFACE FILM IN PSORIASIS

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References (23)

Publisher
American Medical Association
Copyright
Copyright © 1950 American Medical Association. All Rights Reserved.
ISSN
0096-5979
DOI
10.1001/archderm.1950.01530190048004
Publisher site
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Abstract

Abstract ANALYSIS of the surface film of the uninvolved skin in psoriasis as compared with that of the skin of normal persons was undertaken on the basis of a working hypothesis which seems to be in accord with all known data on psoriasis. Psoriasis, on one hand, has features of diseases caused by micro-organisms, such as peripheral spread and central healing of the lesions with formation of annular elements and arciform edges. On the other hand, it is a familial disease with irregularly dominant mendelian inheritance.1 In the present hypothesis it is assumed that it is the susceptibility to the unknown causative organisms which is inherited. The organism is ubiquitous but only those persons who have genetically induced susceptibility will acquire lesions on contact with the organism. Thus psoriasis is not contagious though it is caused by an infective agent. The lesions of psoriasis can be cleared References 1. Hoede, K.: Umwelt und Erblichkeit bei der Entstehung der Schuppenflechte , Würzburg. Abhandl. a. d. Gesamtgeb. d. med. 27:211-254, 1931. 2. Saifer, A., and Kammerer, O. F.: Photometric Determination of Total Cholesterol in Plasma or Serum by a Modified Liebermann-Burchard Reaction , J. Biol. Chem. 164:657-677, 1946. 3. In this series cholesterol and cholesterol ester estimations were carried out according to the method of Saifer and Kammerer.2 4. Rothman, S.; Smiljanic, A. M., and Murphy, J. C.: The Nitrogenous Material on Normal Human Skin Surface , J. Invest. Dermat. 13:317-318, 1949.Crossref 5. Rothman, S., and Sullivan, M. B.: Amino-Acids on the Normal Human Skin Surface , J. Invest. Dermat. 13:319-321, 1949.Crossref 6. Koch, F. C., and Hanke, M. E.: Practical Methods in Biochemistry , ed. 4, Baltimore, Williams & Wilkins Company, 1943, p. 163. 7. Krebs, H., and Henseleit, K.: Untersuchungen über die Harnstoffbildung im Tierkörper , Klin. Wchnschr. 11:757-759 and 1137-1139, 1932Crossref 8. Ztschr. f. physiol. Chem. 210:33-66, 1932.Crossref 9. Kooyman, D. J.: LXI. Lipids of the Skin: Some Changes in the Lipids of the Epidermis During the Process of Keratinization , Arch. Dermat. & Syph. 25:444-450 ( (March) ) 1932. 10. Marchionini, A.; Manz, E., and Huss, F.: Der Cholesteringehalt der Hautoberschicht bei der Seborrhöe und bei der Psoriasis: Beiträge zur Kenntnis der pathochemischen Hautkonstitution des Status seborrhoicus , Arch. f. Dermat. u. Syph. 176:613-645, 1938. 11. Grütz, O., and Bürger, M.: Die Psoriasis als Stoffwechselproblem , Klin. Wchnschr. 12:373-379, 1933 12. Arch. f. Dermat. u. Syph. 170:143-150, 1934. 13. Incedayi, C. K., and Ottenstein, B.: Neuere Untersuchungen über die Beziehungen zwischen Psoriasis und Lipoidosen , Acta dermat.-venereol. 21:674-698, 1940. 14. Madden, J. F., and Barthell, J. H.: Liver Function in Psoriasis: Preliminary Report , J. Invest. Dermat. 9:125-130, 1947. 15. Walsh, E. N.; Clark, D. E.; Dragstedt, L. R., and Becker, S. W.: Further Observations on the Use of Lipocaic in the Treatment of Psoriasis , J. Invest. Dermat. 4:59-67, 1941. 16. Gross, P., and Kesten, B. M.: Treatment of Psoriasis with Lipotropic Substances Derived from Foodstuffs , Arch. Dermat. & Syph. 47:159-174 ( (Feb.) ) 1943. 17. Campana, C., and Gualandi, G.: Tentativo di cura della psoriasi volgare con pancreas "per os," Policlinico (sez. prat.) 54:7-10, 1947. 18. Sinclair, R. G.: Fat Metabolism , Ann. Rev. Biochem. 6:245-268, 1937. 19. McHenry, E. W., and Patterson, J. M.: Lipotropic Factors , Physiol. Rev. 24:128-167, 1944. 20. Ottolenghi-Lodigiani, F.: Studi sulla colesterina della cute umana normale e patologica: Nota II. La presenza nella cute umana del fermento esterificante la colesterina; la colesterinesterasi , Gior. ital. dermat. e. sif. 89:363-373, 1948. 21. Madden, J. F.: Histologic Studies of Uninvolved Skin of Patients with Psoriasis , Arch. Dermat. & Syph. 44:655-664 ( (Oct.) ) 1941. 22. Hier, S. W.; Cornbleet, T., and Bergheim, O.: The Amino-Acids of Human Sweat , J. Biol. Chem. 166:327-333, 1946.

Journal

A.M.A. Archives of Dermatology & Syphilology – American Medical Association

Published: Dec 1, 1950

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