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Sandgärde B Swahn C-G (1976)
Simultaneous determination of the three major monoamine metabolites in brain tissue and body fluids by a mass fragmentographic methodPsychopharmacology, 48
C. Gottfries, I. Gottfries, B. Johansson, R. Olsson, T. Persson, B. Roos, R. Sjöström (1971)
Acid monoamine metabolites in human cerebrospinal fluid and their relations to age and sex.Neuropharmacology, 10 6
G. Ashcroft, T. Crawford, D. Eccleston, D.F. Sharman, ElizabethJ. Macdougall, J.B. Stanton, J.K. Binns (1966)
5-hydroxyindole compounds in the cerebrospinal fluid of patients with psychiatric or neurological diseases.Lancet, 2 7472
B. Wode-Helgodt, B. Fyrö, B. Gullberg, G. Sedvall (1977)
Effect of chlorpromazine treatment on monoamine metabolite levels in cerebrospinal fluid of psychotic patientsActa Psychiatrica Scandinavica, 56
S. Kety (1977)
AND ADOPTIVE RELATIVES OF ADOPTEES WHO BECAME SCHIZOPHRENIC
S. Matthysse, J. Lipinski (1975)
Biochemical aspects of schizophrenia.Annual review of medicine, 26
G. Sedvall, B. Fyrö, H. Nybäck, F. Wiesel, B. Wode-Helgodt (1974)
Mass fragmentometric determination of homovanillic acid in lumbar cerebrospinal fluid of schizophrenic patients during treatment with antipsychotic drugs.Journal of psychiatric research, 11
M. Åsberg, L. Träskman, P. Thoren (1976)
5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor?Archives of general psychiatry, 33 10
S. Kety, D. Rosenthal, P. Wender, F. Schulsinger, B. Jacobsen (1976)
Mental illness in the biological and adoptive families of adopted individuals who have become schizophrenicBehavior Genetics, 6
G. Sedvall, L. Bjerkenstedt, C. Swahn, F. Wiesel, B. Wode-Helgodt (1977)
Mass fragmentography to study dopamine metabolism.Advances in biochemical psychopharmacology, 16
T. Persson, B. Roos (1969)
Acid Metabolites from Monoamines in Cerebrospinal Fluid of Chronic SchizophrenicsBritish Journal of Psychiatry, 115
Bjerkenstedt L Sedvall G (1977)
Advances in Biochemical Psychopharmacology, 16
Bleuler PE (1911)
Dementia praecox oder die Gruppe der Schizophrenien
M. Bowers (1974)
Central dopamine turnover in schizophrenic syndromes.Archives of general psychiatry, 31 1
L. Bertilsson (1973)
Quantitative determination of 4-hydroxy-3-methoxyphenyl glycol and its conjugates in cerebrospinal fluid by mass fragmentography.Journal of chromatography, 87 1
Åsberg M Bertilsson L (1974)
Differential effect of chloripramine and nortriptyline on cerebrospinal fluid metabolites of serotonin and noradrenaline in depressionEur J Clin Pharmacol, 7
A. Carlsson (1978)
Antipsychotic drugs, neurotransmitters, and schizophrenia.The American journal of psychiatry, 135 2
B. Sjöquist, E. Anggard (1972)
Gas chromatographic determination of homovanillic acid in human cerebrospinal fluid by electron capture detection and by mass fragmentography with a deuterated internal standard.Analytical chemistry, 44 14
Rosenthal D Kety SS (1975)
Genetic Research in Psychiatry
G. Sedvall, B. Fyrö, B. Gullberg, H. Nybäck, F. Wiesel, B. Wode-Helgodt (1980)
Relationships in Healthy Volunteers Between Concentrations of Monoamine Metabolites in Cerebrospinal Fluid and Family History of Psychiatric MorbidityBritish Journal of Psychiatry, 136
R. Post, E. Fink, W. Carpenter, F. Goodwin (1975)
Cerebrospinal fluid amine metabolites in acute schizophrenia.Archives of general psychiatry, 32 8
E. Slater, V. Cowie (1971)
The genetics of mental disorders
Korf J Van Praag HM (1971)
Endogenous depressions with and without disturbances in the 5-hydroxytryptamine metabolism: A biochemical classification?Psychopharmacologia, 19
R. Spitzer, J. Endicott, E. Robins (1978)
Research diagnostic criteria: rationale and reliability.Archives of general psychiatry, 35 6
Leif. Bertilsson, Arthur Atkinson, James Althaus, Ase. Harfast, Jan-Erik Lindgren, Bo Holmstedt (1972)
Quantitative determination of 5-hydroxyindole-3-acetic acid in cerebrospinal fluid by gas chromatography-mass spectrometry.Analytical chemistry, 44 8
R. Post, J. Kotin, F. Goodwin, E. Gordon (1973)
Psychomotor activity and cerebrospinal fluid amine metabolites in affective illness.The American journal of psychiatry, 130 1
M. Åsberg, P. Thorén, L. Träskman, L. Bertilsson, V. Ringberger (2003)
"Serotonin depression"--a biochemical subgroup within the affective disorders?Science, 191 4226
R. Post, F. Goodwin, E. Gordon, D. Watkin (1973)
Amine Metabolites in Human Cerebrospinal Fluid: Effects of Cord Transection and Spinal Fluid BlockScience, 179
C. Fri, F. Wiesel, G. Sedvall (1974)
Simultaneous quantification of homovanillic acid and 5-hydroxyindoleacetic acid in cerebrospinal fluid by mass fragmentography.Life sciences, 14 12
Kety SS (1977)
The Impact of Biology on Modern Psychiatry
Abstract • In 36 drug-free schizophrenic patients, lumbar CSF was analyzed by mass fragmentography for the major monoaminergic transmitter metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG). High or deviant concentrations of 5-HIAA were significantly related to a family history of schizophrenia. For patients with deviant 5-HIAA levels, the probability for a family history of schizophrenia was eight times higher than in subjects with normal values. High concentrations of HVA also tended to be significantly related to a family history of schizophrenia. The majority of schizophrenic patients, who lacked family history for the disorder, had normal monoamine metabolite concentrations in CSF. The results suggest a coupling between biochemical variables related to central serotonin and dopamine metabolism and forms of schizophrenia that have a familial disposition. References 1. Bleuler PE: Dementia praecox oder die Gruppe der Schizophrenien . Leipzig, Germany, Deutiche, 1911. 2. Slater E, Cowie VA: The Genetics of Mental Disorders . New York, Oxford University Press Inc, 1971. 3. Kety SS, Rosenthal D, Wender PH, et al: Mental illness in the biological and adoptive families of adopted individuals who have become schizophrenic: A preliminary report based on psychiatric interviews , in Fieve R, Jacobsen B (eds): Genetic Research in Psychiatry . Baltimore, The John Hopkins Press, 1975, pp 147-165. 4. Carlsson A: Antipsychotic drugs, neurotransmitters, and schizophrenia . Am J Psychiatry 135:164-173, 1973. 5. Matthysse S, Lipinsky J: Biochemical aspects of schizophrenia . Annu Rev Med 26:551-565, 1975.Crossref 6. Bertilsson L, Atkinson AJ, Althaus JR, et al: Quantitative determination of 5-hydroxyindole-3-acetic acid in cerebrospinal fluid by gas chromatography-mass spectrometry . Anal Chem 44:1434-1438, 1972.Crossref 7. 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New York, Pergamon Press, 1976, vol 3, pp 255-267. 11. Bertilsson L, Åsberg M, Thorén P: Differential effect of chloripramine and nortriptyline on cerebrospinal fluid metabolites of serotonin and noradrenaline in depression . Eur J Clin Pharmacol 7:365-368, 1974.Crossref 12. Ashcroft GW, Crawford TBB, Eccleston DF, et al: 5-Hydroxyindole compounds in the cerebrospinal fluid of patients with psychiatric or neurological diseases . Lancet 2:1049-1052, 1966.Crossref 13. Persson T, Roos BE: Acid metabolites from monoamine in cerebrospinal fluid of chronic schizophrenics . Br J Psychiatry 115:95-98, 1969.Crossref 14. Bowers MB: Central dopamine turnover in schizophrenic syndromes . Arch Gen Psychiatry 31:50-54, 1974.Crossref 15. Post RM, Fink E, Carpenter WT, et al: Cerebrospinal fluid amine metabolites in acute schizophrenia . Arch Gen Psychiatry 32:1063-1069, 1975.Crossref 16. Sedvall G, Bjerkenstedt L, Swahn C-G, et al: Mass fragmentography to study dopamine metabolism , in Costa E, Gessa GL (eds): Advances in Biochemical Psychopharmacology . New York, Raven Press, 1977, vol 16, pp 343-348. 17. Gottfries CG, Gottfries I, Johansson B, et al: Acid monoamine metabolites in human cerebrospinal fluid and their relations to age and sex . Neuropharmacology 10:665-672, 1971.Crossref 18. Spitzer RL, Endicott J, Robins E: Research Diagnostic Criteria: Rationale and reliability . Arch Gen Psychiatry 35:773-782, 1978.Crossref 19. Fri C-G, Wiesel F-A, Sedvall G: Simultaneous quantification of homovanillic acid and 5-hydroxyindoleacetic acid in cerebrospinal fluid by mass fragmentography . Life Sci 14:2469-2480, 1974.Crossref 20. Swahn C-G, Sandgärde B, Wiesel F-A, et al: Simultaneous determination of the three major monoamine metabolites in brain tissue and body fluids by a mass fragmentographic method . Psychopharmacology 48:147-152, 1976.Crossref 21. Sedvall G, Fyrö B, Gullberg B, et al: Relationships in healthy volunteers between concentrations of monoamine metabolites in cerebrospinal fluid and family history of psychiatric morbidity . Br J Psychiatry 136:366-374, 1980.Crossref 22. Wode-Helgodt B, Fyrö B, Gullberg B, et al: Effect of chlorpromazine treatment on monoamine metabolite levels in cerebrospinal fluid of psychotic patients . Acta Psychiatr Scand 56:129-142, 1977.Crossref 23. Post RM, Goodwin FK, Gordon E, et al: Amine metabolites in human cerebrospinal fluid: Effects of cord transection and spinal fluid block . Science 179:897-899, 1973.Crossref 24. Post RM, Kotin J, Goodwin FK: Psychomotor activity and cerebrospinal fluid amine metabolites in affective illness . Am J Psychiatry 130:67-72, 1973. 25. Van Praag HM, Korf J: Endogenous depressions with and without disturbances in the 5-hydroxytryptamine metabolism: A biochemical classification? Psychopharmacologia 19:148-152, 1971.Crossref 26. Åsberg M, Thorén P, Träskman L, et al: Serotonin depression: A biochemical subgroup within the affective disorders? Science 191:478-480, 1976.Crossref 27. Åsberg M, Träskman L, Thorén P: 5-HIAA in the cerebrospinal fluid: A biochemical suicide predictor? Arch Gen Psychiatry 33:1193-1197, 1976.Crossref 28. Kety SS: Genetic aspects of schizophrenia: Observations on the biological and adoptive relatives of adoptees who became schizophrenic , in Gershon RH, Belmaker SS, Kety M (eds): The Impact of Biology on Modern Psychiatry . New York, Plenum Press Inc, 1977, pp 195-206.
Archives of General Psychiatry – American Medical Association
Published: Oct 1, 1980
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