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Aberrant Monoamine Metabolite Levels in CSF and Family History of Schizophrenia: Their Relationships in Schizophrenic Patients

Aberrant Monoamine Metabolite Levels in CSF and Family History of Schizophrenia: Their... Abstract • In 36 drug-free schizophrenic patients, lumbar CSF was analyzed by mass fragmentography for the major monoaminergic transmitter metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG). High or deviant concentrations of 5-HIAA were significantly related to a family history of schizophrenia. For patients with deviant 5-HIAA levels, the probability for a family history of schizophrenia was eight times higher than in subjects with normal values. High concentrations of HVA also tended to be significantly related to a family history of schizophrenia. The majority of schizophrenic patients, who lacked family history for the disorder, had normal monoamine metabolite concentrations in CSF. The results suggest a coupling between biochemical variables related to central serotonin and dopamine metabolism and forms of schizophrenia that have a familial disposition. References 1. Bleuler PE: Dementia praecox oder die Gruppe der Schizophrenien . Leipzig, Germany, Deutiche, 1911. 2. Slater E, Cowie VA: The Genetics of Mental Disorders . New York, Oxford University Press Inc, 1971. 3. Kety SS, Rosenthal D, Wender PH, et al: Mental illness in the biological and adoptive families of adopted individuals who have become schizophrenic: A preliminary report based on psychiatric interviews , in Fieve R, Jacobsen B (eds): Genetic Research in Psychiatry . Baltimore, The John Hopkins Press, 1975, pp 147-165. 4. Carlsson A: Antipsychotic drugs, neurotransmitters, and schizophrenia . Am J Psychiatry 135:164-173, 1973. 5. Matthysse S, Lipinsky J: Biochemical aspects of schizophrenia . Annu Rev Med 26:551-565, 1975.Crossref 6. Bertilsson L, Atkinson AJ, Althaus JR, et al: Quantitative determination of 5-hydroxyindole-3-acetic acid in cerebrospinal fluid by gas chromatography-mass spectrometry . Anal Chem 44:1434-1438, 1972.Crossref 7. Sjöqvist B, Anggård E: Gas chromatographic determination of homovanillic acid in human cerebrospinal fluid by electron capture detection and by mass fragmentography with a deuterated internal standard . Anal Chem 44:2297-2301, 1972.Crossref 8. Bertilsson L: Quantitative determination of 4-hydroxy-3-methoxyphenylglycol and its conjugates in cerebrospinal fluid by mass fragmentography . J Chromatogr 87:147-153, 1973.Crossref 9. Sedvall G, Fyrö B, Nybäck H, et al: Mass fragmentometric determination of homovanillic acid in lumbar cerebrospinal fluid of schizophrenic patients during treatment with antipsychotic drugs . J Psychiatr Res 11:75-80, 1974.Crossref 10. Sedvall G, Alfredsson G, Bjerkenstedt L, et al: Selective effects of psychoactive drugs on levels of monoamine metabolites and prolactin in cerebrospinal fluid of psychiatric patients, in Paasonen M, Tuomisto J (eds): Proceedings of the Sixth International Congress of Pharmacology: Helsinki, 1975. New York, Pergamon Press, 1976, vol 3, pp 255-267. 11. Bertilsson L, Åsberg M, Thorén P: Differential effect of chloripramine and nortriptyline on cerebrospinal fluid metabolites of serotonin and noradrenaline in depression . Eur J Clin Pharmacol 7:365-368, 1974.Crossref 12. Ashcroft GW, Crawford TBB, Eccleston DF, et al: 5-Hydroxyindole compounds in the cerebrospinal fluid of patients with psychiatric or neurological diseases . Lancet 2:1049-1052, 1966.Crossref 13. Persson T, Roos BE: Acid metabolites from monoamine in cerebrospinal fluid of chronic schizophrenics . Br J Psychiatry 115:95-98, 1969.Crossref 14. Bowers MB: Central dopamine turnover in schizophrenic syndromes . Arch Gen Psychiatry 31:50-54, 1974.Crossref 15. Post RM, Fink E, Carpenter WT, et al: Cerebrospinal fluid amine metabolites in acute schizophrenia . Arch Gen Psychiatry 32:1063-1069, 1975.Crossref 16. Sedvall G, Bjerkenstedt L, Swahn C-G, et al: Mass fragmentography to study dopamine metabolism , in Costa E, Gessa GL (eds): Advances in Biochemical Psychopharmacology . New York, Raven Press, 1977, vol 16, pp 343-348. 17. Gottfries CG, Gottfries I, Johansson B, et al: Acid monoamine metabolites in human cerebrospinal fluid and their relations to age and sex . Neuropharmacology 10:665-672, 1971.Crossref 18. Spitzer RL, Endicott J, Robins E: Research Diagnostic Criteria: Rationale and reliability . Arch Gen Psychiatry 35:773-782, 1978.Crossref 19. Fri C-G, Wiesel F-A, Sedvall G: Simultaneous quantification of homovanillic acid and 5-hydroxyindoleacetic acid in cerebrospinal fluid by mass fragmentography . Life Sci 14:2469-2480, 1974.Crossref 20. Swahn C-G, Sandgärde B, Wiesel F-A, et al: Simultaneous determination of the three major monoamine metabolites in brain tissue and body fluids by a mass fragmentographic method . Psychopharmacology 48:147-152, 1976.Crossref 21. Sedvall G, Fyrö B, Gullberg B, et al: Relationships in healthy volunteers between concentrations of monoamine metabolites in cerebrospinal fluid and family history of psychiatric morbidity . Br J Psychiatry 136:366-374, 1980.Crossref 22. Wode-Helgodt B, Fyrö B, Gullberg B, et al: Effect of chlorpromazine treatment on monoamine metabolite levels in cerebrospinal fluid of psychotic patients . Acta Psychiatr Scand 56:129-142, 1977.Crossref 23. Post RM, Goodwin FK, Gordon E, et al: Amine metabolites in human cerebrospinal fluid: Effects of cord transection and spinal fluid block . Science 179:897-899, 1973.Crossref 24. Post RM, Kotin J, Goodwin FK: Psychomotor activity and cerebrospinal fluid amine metabolites in affective illness . Am J Psychiatry 130:67-72, 1973. 25. Van Praag HM, Korf J: Endogenous depressions with and without disturbances in the 5-hydroxytryptamine metabolism: A biochemical classification? Psychopharmacologia 19:148-152, 1971.Crossref 26. Åsberg M, Thorén P, Träskman L, et al: Serotonin depression: A biochemical subgroup within the affective disorders? Science 191:478-480, 1976.Crossref 27. Åsberg M, Träskman L, Thorén P: 5-HIAA in the cerebrospinal fluid: A biochemical suicide predictor? Arch Gen Psychiatry 33:1193-1197, 1976.Crossref 28. Kety SS: Genetic aspects of schizophrenia: Observations on the biological and adoptive relatives of adoptees who became schizophrenic , in Gershon RH, Belmaker SS, Kety M (eds): The Impact of Biology on Modern Psychiatry . New York, Plenum Press Inc, 1977, pp 195-206. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of General Psychiatry American Medical Association

Aberrant Monoamine Metabolite Levels in CSF and Family History of Schizophrenia: Their Relationships in Schizophrenic Patients

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Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0003-990X
eISSN
1598-3636
DOI
10.1001/archpsyc.1980.01780230031004
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Abstract

Abstract • In 36 drug-free schizophrenic patients, lumbar CSF was analyzed by mass fragmentography for the major monoaminergic transmitter metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG). High or deviant concentrations of 5-HIAA were significantly related to a family history of schizophrenia. For patients with deviant 5-HIAA levels, the probability for a family history of schizophrenia was eight times higher than in subjects with normal values. High concentrations of HVA also tended to be significantly related to a family history of schizophrenia. The majority of schizophrenic patients, who lacked family history for the disorder, had normal monoamine metabolite concentrations in CSF. The results suggest a coupling between biochemical variables related to central serotonin and dopamine metabolism and forms of schizophrenia that have a familial disposition. References 1. Bleuler PE: Dementia praecox oder die Gruppe der Schizophrenien . Leipzig, Germany, Deutiche, 1911. 2. Slater E, Cowie VA: The Genetics of Mental Disorders . New York, Oxford University Press Inc, 1971. 3. Kety SS, Rosenthal D, Wender PH, et al: Mental illness in the biological and adoptive families of adopted individuals who have become schizophrenic: A preliminary report based on psychiatric interviews , in Fieve R, Jacobsen B (eds): Genetic Research in Psychiatry . Baltimore, The John Hopkins Press, 1975, pp 147-165. 4. Carlsson A: Antipsychotic drugs, neurotransmitters, and schizophrenia . Am J Psychiatry 135:164-173, 1973. 5. Matthysse S, Lipinsky J: Biochemical aspects of schizophrenia . Annu Rev Med 26:551-565, 1975.Crossref 6. Bertilsson L, Atkinson AJ, Althaus JR, et al: Quantitative determination of 5-hydroxyindole-3-acetic acid in cerebrospinal fluid by gas chromatography-mass spectrometry . Anal Chem 44:1434-1438, 1972.Crossref 7. Sjöqvist B, Anggård E: Gas chromatographic determination of homovanillic acid in human cerebrospinal fluid by electron capture detection and by mass fragmentography with a deuterated internal standard . Anal Chem 44:2297-2301, 1972.Crossref 8. Bertilsson L: Quantitative determination of 4-hydroxy-3-methoxyphenylglycol and its conjugates in cerebrospinal fluid by mass fragmentography . J Chromatogr 87:147-153, 1973.Crossref 9. Sedvall G, Fyrö B, Nybäck H, et al: Mass fragmentometric determination of homovanillic acid in lumbar cerebrospinal fluid of schizophrenic patients during treatment with antipsychotic drugs . J Psychiatr Res 11:75-80, 1974.Crossref 10. Sedvall G, Alfredsson G, Bjerkenstedt L, et al: Selective effects of psychoactive drugs on levels of monoamine metabolites and prolactin in cerebrospinal fluid of psychiatric patients, in Paasonen M, Tuomisto J (eds): Proceedings of the Sixth International Congress of Pharmacology: Helsinki, 1975. New York, Pergamon Press, 1976, vol 3, pp 255-267. 11. Bertilsson L, Åsberg M, Thorén P: Differential effect of chloripramine and nortriptyline on cerebrospinal fluid metabolites of serotonin and noradrenaline in depression . Eur J Clin Pharmacol 7:365-368, 1974.Crossref 12. Ashcroft GW, Crawford TBB, Eccleston DF, et al: 5-Hydroxyindole compounds in the cerebrospinal fluid of patients with psychiatric or neurological diseases . Lancet 2:1049-1052, 1966.Crossref 13. Persson T, Roos BE: Acid metabolites from monoamine in cerebrospinal fluid of chronic schizophrenics . Br J Psychiatry 115:95-98, 1969.Crossref 14. Bowers MB: Central dopamine turnover in schizophrenic syndromes . Arch Gen Psychiatry 31:50-54, 1974.Crossref 15. Post RM, Fink E, Carpenter WT, et al: Cerebrospinal fluid amine metabolites in acute schizophrenia . Arch Gen Psychiatry 32:1063-1069, 1975.Crossref 16. Sedvall G, Bjerkenstedt L, Swahn C-G, et al: Mass fragmentography to study dopamine metabolism , in Costa E, Gessa GL (eds): Advances in Biochemical Psychopharmacology . New York, Raven Press, 1977, vol 16, pp 343-348. 17. Gottfries CG, Gottfries I, Johansson B, et al: Acid monoamine metabolites in human cerebrospinal fluid and their relations to age and sex . Neuropharmacology 10:665-672, 1971.Crossref 18. Spitzer RL, Endicott J, Robins E: Research Diagnostic Criteria: Rationale and reliability . Arch Gen Psychiatry 35:773-782, 1978.Crossref 19. Fri C-G, Wiesel F-A, Sedvall G: Simultaneous quantification of homovanillic acid and 5-hydroxyindoleacetic acid in cerebrospinal fluid by mass fragmentography . Life Sci 14:2469-2480, 1974.Crossref 20. Swahn C-G, Sandgärde B, Wiesel F-A, et al: Simultaneous determination of the three major monoamine metabolites in brain tissue and body fluids by a mass fragmentographic method . Psychopharmacology 48:147-152, 1976.Crossref 21. Sedvall G, Fyrö B, Gullberg B, et al: Relationships in healthy volunteers between concentrations of monoamine metabolites in cerebrospinal fluid and family history of psychiatric morbidity . Br J Psychiatry 136:366-374, 1980.Crossref 22. Wode-Helgodt B, Fyrö B, Gullberg B, et al: Effect of chlorpromazine treatment on monoamine metabolite levels in cerebrospinal fluid of psychotic patients . Acta Psychiatr Scand 56:129-142, 1977.Crossref 23. Post RM, Goodwin FK, Gordon E, et al: Amine metabolites in human cerebrospinal fluid: Effects of cord transection and spinal fluid block . Science 179:897-899, 1973.Crossref 24. Post RM, Kotin J, Goodwin FK: Psychomotor activity and cerebrospinal fluid amine metabolites in affective illness . Am J Psychiatry 130:67-72, 1973. 25. Van Praag HM, Korf J: Endogenous depressions with and without disturbances in the 5-hydroxytryptamine metabolism: A biochemical classification? Psychopharmacologia 19:148-152, 1971.Crossref 26. Åsberg M, Thorén P, Träskman L, et al: Serotonin depression: A biochemical subgroup within the affective disorders? Science 191:478-480, 1976.Crossref 27. Åsberg M, Träskman L, Thorén P: 5-HIAA in the cerebrospinal fluid: A biochemical suicide predictor? Arch Gen Psychiatry 33:1193-1197, 1976.Crossref 28. Kety SS: Genetic aspects of schizophrenia: Observations on the biological and adoptive relatives of adoptees who became schizophrenic , in Gershon RH, Belmaker SS, Kety M (eds): The Impact of Biology on Modern Psychiatry . New York, Plenum Press Inc, 1977, pp 195-206.

Journal

Archives of General PsychiatryAmerican Medical Association

Published: Oct 1, 1980

References