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A Variant of Hoigne's Syndrome Following Intramuscular Cefoxitin Sodium?

A Variant of Hoigne's Syndrome Following Intramuscular Cefoxitin Sodium? Abstract Sir.—In the April 1985 issue of AJDC, Silber and D'Angelo1 described four teenagers who manifested Hoigne's syndrome, an acute, toxic, nonallergic reaction to the intramuscular (IM) administration of aqueous penicillin G procaine. I encountered a patient with a presentation similar to that of their four patients who had a similar reaction to an IM injection of cefoxitin sodium. A 17-year-old girl presented to the emergency room with abdominal pain, fever, and vaginal discharge of two weeks' duration, her symptoms having intensified on the night of presentation. Her boyfriend had complained of a urethral discharge. Appropriate cultures were taken, and a diagnosis of pelvic inflammatory disease (PTD) was made. Because the girl thought she might be allergic to penicillin, cefotoxin sodium (Mefoxin) (2.0 g) was administered IM in a divided dose. She was felt to have low-grade disease, and the intention was to treat her as an outpatient. Immediately References 1. Silber TJ, D'Angelo L: Psychosis and seizures following the injection of penicillin G procaine . AJDC 1985;139:335-337. 2. Utley PM, Lucas JB, Billings TE: Acute psychotic reactions to aqueous procaine penicillin . South Med J 1966;59:1271-1274.Crossref 3. Washington AE, Sweet RL, Shafer MB: Pelvic inflammatory disease and its sequelae in adolescents . J Adolesc Health Care 1985;6: 298-310.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

A Variant of Hoigne's Syndrome Following Intramuscular Cefoxitin Sodium?

American Journal of Diseases of Children , Volume 141 (5) – May 1, 1987

A Variant of Hoigne's Syndrome Following Intramuscular Cefoxitin Sodium?

Abstract

Abstract Sir.—In the April 1985 issue of AJDC, Silber and D'Angelo1 described four teenagers who manifested Hoigne's syndrome, an acute, toxic, nonallergic reaction to the intramuscular (IM) administration of aqueous penicillin G procaine. I encountered a patient with a presentation similar to that of their four patients who had a similar reaction to an IM injection of cefoxitin sodium. A 17-year-old girl presented to the emergency room with abdominal pain, fever, and vaginal...
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References (4)

Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1987.04460050017007
Publisher site
See Article on Publisher Site

Abstract

Abstract Sir.—In the April 1985 issue of AJDC, Silber and D'Angelo1 described four teenagers who manifested Hoigne's syndrome, an acute, toxic, nonallergic reaction to the intramuscular (IM) administration of aqueous penicillin G procaine. I encountered a patient with a presentation similar to that of their four patients who had a similar reaction to an IM injection of cefoxitin sodium. A 17-year-old girl presented to the emergency room with abdominal pain, fever, and vaginal discharge of two weeks' duration, her symptoms having intensified on the night of presentation. Her boyfriend had complained of a urethral discharge. Appropriate cultures were taken, and a diagnosis of pelvic inflammatory disease (PTD) was made. Because the girl thought she might be allergic to penicillin, cefotoxin sodium (Mefoxin) (2.0 g) was administered IM in a divided dose. She was felt to have low-grade disease, and the intention was to treat her as an outpatient. Immediately References 1. Silber TJ, D'Angelo L: Psychosis and seizures following the injection of penicillin G procaine . AJDC 1985;139:335-337. 2. Utley PM, Lucas JB, Billings TE: Acute psychotic reactions to aqueous procaine penicillin . South Med J 1966;59:1271-1274.Crossref 3. Washington AE, Sweet RL, Shafer MB: Pelvic inflammatory disease and its sequelae in adolescents . J Adolesc Health Care 1985;6: 298-310.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: May 1, 1987

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