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A Therapeutic Suggestion for Defects in Keratinization

A Therapeutic Suggestion for Defects in Keratinization Abstract To the Editor.— The article entitled "Cornoid Lamella in Pachyonychia Congenita," by Wilkin et al, in the December 1978 Archives (114:1795-1796), aroused our interest because of the association of several manifestations of disordered keratinization, namely, thickened fingernails and toenails, follicular keratotic papules on the elbows and knees, and keratoses and ruptured bullae on the soles, together with a biopsy specimen from a keratotic papule showing a cornoid lamella that was characteristic of porokeratosis of Mibelli. There was no mention of treatment in the case reported.We would like to offer a therapeutic suggestion, one we have found to be of value in several dermatoses characterized by defects in keratinization, such as Darier's disease,1 pityriasis rubra pilaris,2 and acne vulgaris.3 Although we have not had the opportunity of treating either pachyonychia congenita or porokeratosis of Mibelli by this method, the treatment is harmless and might conceivably prove effective. References 1. Ayres S Jr, Mihan R: Keratosis follicularis (Darier's disease) . Arch Dermatol 106:909-910, 1972.Crossref 2. Ayres S Jr, Mihan R: Is vitamin E involved in the autoimmune mechanism? Cutis 21:321-325, 1978. 3. Ayres S Jr, Mihan R: Acne vulgaris and lipid peroxidation: New concepts in pathogenesis and treatment . Int Soc Trop Dermatol 17:305-307, 1978.Crossref 4. Ames SR: Factors affecting absorption, transport, and storage of vitamin A. Am J Clin Nutr 22:934-935, 1969. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

A Therapeutic Suggestion for Defects in Keratinization

Archives of Dermatology , Volume 115 (7) – Jul 1, 1979

A Therapeutic Suggestion for Defects in Keratinization

Abstract

Abstract To the Editor.— The article entitled "Cornoid Lamella in Pachyonychia Congenita," by Wilkin et al, in the December 1978 Archives (114:1795-1796), aroused our interest because of the association of several manifestations of disordered keratinization, namely, thickened fingernails and toenails, follicular keratotic papules on the elbows and knees, and keratoses and ruptured bullae on the soles, together with a biopsy specimen from a keratotic papule showing a cornoid...
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Publisher
American Medical Association
Copyright
Copyright © 1979 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1979.04010070003005
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— The article entitled "Cornoid Lamella in Pachyonychia Congenita," by Wilkin et al, in the December 1978 Archives (114:1795-1796), aroused our interest because of the association of several manifestations of disordered keratinization, namely, thickened fingernails and toenails, follicular keratotic papules on the elbows and knees, and keratoses and ruptured bullae on the soles, together with a biopsy specimen from a keratotic papule showing a cornoid lamella that was characteristic of porokeratosis of Mibelli. There was no mention of treatment in the case reported.We would like to offer a therapeutic suggestion, one we have found to be of value in several dermatoses characterized by defects in keratinization, such as Darier's disease,1 pityriasis rubra pilaris,2 and acne vulgaris.3 Although we have not had the opportunity of treating either pachyonychia congenita or porokeratosis of Mibelli by this method, the treatment is harmless and might conceivably prove effective. References 1. Ayres S Jr, Mihan R: Keratosis follicularis (Darier's disease) . Arch Dermatol 106:909-910, 1972.Crossref 2. Ayres S Jr, Mihan R: Is vitamin E involved in the autoimmune mechanism? Cutis 21:321-325, 1978. 3. Ayres S Jr, Mihan R: Acne vulgaris and lipid peroxidation: New concepts in pathogenesis and treatment . Int Soc Trop Dermatol 17:305-307, 1978.Crossref 4. Ames SR: Factors affecting absorption, transport, and storage of vitamin A. Am J Clin Nutr 22:934-935, 1969.

Journal

Archives of DermatologyAmerican Medical Association

Published: Jul 1, 1979

References

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