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A Test for Abnormal Hemoglobins in Umbilical Cord Blood

A Test for Abnormal Hemoglobins in Umbilical Cord Blood Abstract • This article describes a rapid, simple, and inexpensive method for testing the cord blood of infants for the common hemoglobinopathies by electrophoresis using cellulose polycetate strips. In a study of 7,500 umbilical cord blood specimens, 11% were found to contain an abnormal hemoglobin. While the importance of evaluating cord blood in a screening program for hemoglobinopathies is evident, the procedure must be accurate, verified, and followed by proper counseling. (Am J Dis Child 130:805-806, 1976) References 1. Pearson HA, O'Brien RT, McIntosh S, et al: Routine screening of umbilical cord blood for sickle cell diseases . JAMA 227:420-421, 1974.Crossref 2. Powards D, Schroeder WA, White L: Rapid diagnosis of sickle cell disease at birth by microcolumn chromatography . Pediatrics 55:630-635, 1975. 3. Friedman S, Atwater J, Gill FM, et al: Alpha-thalassemia in Negro infants . Pediatr Res 8:955-959, 1974.Crossref 4. Weatherall DJ: Relationship of hemoglobin Barts and H to alpha-thalassemia . Ann NY Acad Sci 119:463-473, 1964.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1976.02120090015003
Publisher site
See Article on Publisher Site

Abstract

Abstract • This article describes a rapid, simple, and inexpensive method for testing the cord blood of infants for the common hemoglobinopathies by electrophoresis using cellulose polycetate strips. In a study of 7,500 umbilical cord blood specimens, 11% were found to contain an abnormal hemoglobin. While the importance of evaluating cord blood in a screening program for hemoglobinopathies is evident, the procedure must be accurate, verified, and followed by proper counseling. (Am J Dis Child 130:805-806, 1976) References 1. Pearson HA, O'Brien RT, McIntosh S, et al: Routine screening of umbilical cord blood for sickle cell diseases . JAMA 227:420-421, 1974.Crossref 2. Powards D, Schroeder WA, White L: Rapid diagnosis of sickle cell disease at birth by microcolumn chromatography . Pediatrics 55:630-635, 1975. 3. Friedman S, Atwater J, Gill FM, et al: Alpha-thalassemia in Negro infants . Pediatr Res 8:955-959, 1974.Crossref 4. Weatherall DJ: Relationship of hemoglobin Barts and H to alpha-thalassemia . Ann NY Acad Sci 119:463-473, 1964.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Aug 1, 1976

References