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A STUDY OF THE HEMOLYTIC ACTIVITY OF THE SPLEEN IN PERNICIOUS ANEMIA

A STUDY OF THE HEMOLYTIC ACTIVITY OF THE SPLEEN IN PERNICIOUS ANEMIA Abstract There is a certain amount of evidence that the increased blood destruction occurring in pernicious anemia is in some way associated with an abnormal functioning of the spleen, since removal of this organ brings about a marked reduction in the quantity of blood destroyed. This reduction has been found in almost every instance where the blood destruction was studied before and after splenectomy.1 Eppinger and Ranzi2 and the author,3 who report the two largest series of cases, found that the greatly increased hemolysis present before operation showed a constant and marked decrease afterwards, reaching normal in all but two or three cases. Yet the manner in which the spleen acted to produce increased blood destruction is as yet undetermined. The literature contains comparatively few observations on the hemolytic activity of the human spleen either in normal or pathological conditions. Benard4 tested salt solution extracts of two References 1. The quantitative estimation of urobilin in the stool was used as an index to the degree of blood destruction. 2. Eppinger, H., and Ranzi, E.: Mitt. a. d. Grenzgeb. d. Med. u. Chir. , 1914, xxvii, 796. 3. Robertson, O. H. : The Archives Int. Med. , 1915, xvi, 429.Crossref 4. Benard, H.: Thèse de Paris, 1913. 5. Antonelli : Progressive Med. , (June) , 1914, p. 327. 6. Port, Fr.: Berl. klin. Wchnschr. , 1914, li, 546. 7. McPhedran, W. F.: Jour. Exper. Med. , 1913, xviii, 527.Crossref 8. Eppinger, H.: Berl. klin. Wchnschr. , 1913, 1, 2409. 9. Huber, O. R. C.: Berl. klin. Wchnschr. , 1913, 1, 2179. 10. Widal Abrami and Brule : Bull. Soc. d. hôp. de Paris , 1912, No. (13) . 11. Banti: Semaine méd., 1913, p. 313. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

A STUDY OF THE HEMOLYTIC ACTIVITY OF THE SPLEEN IN PERNICIOUS ANEMIA

Archives of Internal Medicine , Volume XVI (4) – Oct 1, 1915

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Publisher
American Medical Association
Copyright
Copyright © 1915 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1915.00080040148010
Publisher site
See Article on Publisher Site

Abstract

Abstract There is a certain amount of evidence that the increased blood destruction occurring in pernicious anemia is in some way associated with an abnormal functioning of the spleen, since removal of this organ brings about a marked reduction in the quantity of blood destroyed. This reduction has been found in almost every instance where the blood destruction was studied before and after splenectomy.1 Eppinger and Ranzi2 and the author,3 who report the two largest series of cases, found that the greatly increased hemolysis present before operation showed a constant and marked decrease afterwards, reaching normal in all but two or three cases. Yet the manner in which the spleen acted to produce increased blood destruction is as yet undetermined. The literature contains comparatively few observations on the hemolytic activity of the human spleen either in normal or pathological conditions. Benard4 tested salt solution extracts of two References 1. The quantitative estimation of urobilin in the stool was used as an index to the degree of blood destruction. 2. Eppinger, H., and Ranzi, E.: Mitt. a. d. Grenzgeb. d. Med. u. Chir. , 1914, xxvii, 796. 3. Robertson, O. H. : The Archives Int. Med. , 1915, xvi, 429.Crossref 4. Benard, H.: Thèse de Paris, 1913. 5. Antonelli : Progressive Med. , (June) , 1914, p. 327. 6. Port, Fr.: Berl. klin. Wchnschr. , 1914, li, 546. 7. McPhedran, W. F.: Jour. Exper. Med. , 1913, xviii, 527.Crossref 8. Eppinger, H.: Berl. klin. Wchnschr. , 1913, 1, 2409. 9. Huber, O. R. C.: Berl. klin. Wchnschr. , 1913, 1, 2179. 10. Widal Abrami and Brule : Bull. Soc. d. hôp. de Paris , 1912, No. (13) . 11. Banti: Semaine méd., 1913, p. 313.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Oct 1, 1915

References

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