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A Study of Late Radiation Necrosis Following Therapy of Skin Cancer

A Study of Late Radiation Necrosis Following Therapy of Skin Cancer Abstract The utilization of roentgen rays in cancer therapy obviously is dependent upon their capacity to destroy the malignant growth without producing destruction of the surrounding normal tissue. However, in basal- and squamous-cell cancer of the skin, the margin of difference between what is generally regarded as "the tumor lethal dose" and that which will produce permanent destruction (necrosis) of the normal skin and subcutaneous tissues, is a somewhat narrow one. It should not be surprising, therefore, that if the normal tissue tolerance were for any reason slightly lowered, it might approach that of the tumor lethal dose. Consequently, surrounding tissue, as well as the tumor, might be destroyed. Although these basic principles have been known for years, there appears to be a tendency to associate the phenomenon of tissue necrosis solely with excessive overdosage. The late radiation changes resulting from total dosages far in References 1. Merrell, M., and Shulman, L. E.: Determination of Prognosis in Chronic Disease, Illustrated by Systemic Lupus Erythematosus , J. Chronic Dis. 1:12 ( (Jan.) ) 1955.Crossref 2. Windeyer, B. W.: Symposium: Radiation Necrosis , Brit. J. Radiol. 20:274 ( (July) ) 1947.Crossref 3. Paterson, R.: The Treatment of Malignant Disease by Radium and X-Rays, London, Edward Arnold & Company, 1949, p. 168. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

A Study of Late Radiation Necrosis Following Therapy of Skin Cancer

A.M.A. Archives of Dermatology , Volume 72 (5) – Nov 1, 1955

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Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1955.03730350048008
Publisher site
See Article on Publisher Site

Abstract

Abstract The utilization of roentgen rays in cancer therapy obviously is dependent upon their capacity to destroy the malignant growth without producing destruction of the surrounding normal tissue. However, in basal- and squamous-cell cancer of the skin, the margin of difference between what is generally regarded as "the tumor lethal dose" and that which will produce permanent destruction (necrosis) of the normal skin and subcutaneous tissues, is a somewhat narrow one. It should not be surprising, therefore, that if the normal tissue tolerance were for any reason slightly lowered, it might approach that of the tumor lethal dose. Consequently, surrounding tissue, as well as the tumor, might be destroyed. Although these basic principles have been known for years, there appears to be a tendency to associate the phenomenon of tissue necrosis solely with excessive overdosage. The late radiation changes resulting from total dosages far in References 1. Merrell, M., and Shulman, L. E.: Determination of Prognosis in Chronic Disease, Illustrated by Systemic Lupus Erythematosus , J. Chronic Dis. 1:12 ( (Jan.) ) 1955.Crossref 2. Windeyer, B. W.: Symposium: Radiation Necrosis , Brit. J. Radiol. 20:274 ( (July) ) 1947.Crossref 3. Paterson, R.: The Treatment of Malignant Disease by Radium and X-Rays, London, Edward Arnold & Company, 1949, p. 168.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Nov 1, 1955

References