Abstract Several years ago, a striking advance in radiologic examination of the biliary tract enabled the common duct to be visualized by a new solution administered intravenously.1 Shortly thereafter it was learned that the biliary tract could be outlined in the absence of the gallbladder.2 This new technical accomplishment was made possible by a rather highly concentrated iodine derivative, prepared as a solution and administered intravenously. Iodipamide (Cholografin) methylglucamine is a colorless solution of the bis N-methylglucamine salt of 3-3'(adipoyldiimino) bis (2,4,6-triiodobenzoic acid). Since its introduction, different techniques have been employed in order to obtain the best radiographic reproduction of the biliary tract, criteria have been established in order to standardize interpretations, and, with the ever-increasing number of examinations, information has been accumulated to evaluate the advantages and limitations of this diagnostic procedure. Iodipamide, being isotonic, is administered intravenously and under normal conditions is excreted promptly by the liver. References 1. Frommhold, W.: Ein neuartiges Kontrastmittel für die intravenöse Cholezystographie , Fortschr. Geb. Röntgenstrahlen 79:283, 1953.Crossref 2. Sklaroff, D. M.; Cohn, E. M.; Orloff, T. L., and Gershon-Cohen, J.: The Common Bile Duct in the Postcholecystectomy Patient , A. M. A. Arch. Surg. 70:559, 1955.Crossref 3. Shehadi, W. H.: Intravenous Cholecystocholangiography , J. A. M. A. 159:1350, 1955.Crossref 4. Orloff, T. L.: Intravenous Choledocholaminography , Am. J. Roentgenol. 2:804, 1954. 5. Mitchell, D. J.: Basic Combined Cholecystangiography , Brit. J. Radiol. 29:133, 1956.Crossref 6. Lajos, S.: Durch Biligrafin eröffnete neue Wege für die Röntgenuntersuchung des Gallensystems , Fortschr. Geb. Röntgenstrahlen 83:776, 1955.Crossref 7. Orloff, T. L.; Sklaroff, D. M.; Cohn, E. M., and Gershon-Cohen, J.: Intravenous Choledochography with a New Contrast Medium, "Cholografin." Radiology 62:868, 1954.Crossref 8. Jordan, P. H.: The Use of Intravenous Cholangiocholecystography in the Diagnosis of Acute Conditions of the Abdomen , Surg. Gynec. & Obst. 102:218, 1956. 9. Doubilet, H., and Mulholland, J. H.: Recurrent Acute Pancreatitis , Ann. Surg. 128:609, 1948. 10. Cohn, E. M.; Orloff, T. L.; Sklaroff, D. M., and Gershon-Cohen, J.: The Use of Cholografin in the Postcholecystectomy Syndrome , Ann. Int. Med. 42:59, 1955. 11. McDonough, F. E., and Wise, R. E.: Limitations of the Clinical Application of Intravenous Cholangiography in Determining Disease of the Bile Ducts After Cholecystectomy , Gastroenterology 29:771, 1955. 12. Sparkman, R. S., and Ellis, P. R.: Intravenous Cholecyst-Cholangiography in Emergency Abdominal Diagnosis , Ann. Surg. 143:416, 1956. 13. Kremens, V.; Berger, S. M., and Cohn, E. M.: Comparison of Rapid Intravenously and Orally Administered Contrast Mediums for Routine Gall Bladder Study , New England J. Med. 254:705, 1956. 14. Kantor, H. G.; Evans, J. A., and Glenn, F.: Cholangiography: Critical Analysis , A. M. A. Arch. Surg. 70:237, 1955. 15. Aldridge, N. H.: Cholecystography and Cholangiography: A Review of Present Methods of Examination , Am. J. M. Sc. 231:701, 1956. 16. Cohn, E. M.; Berger, S. M., and Kremens, V.: Cholecystography in the Presence of Jaundice , Ann. Int. Med. 46:53, 1957. 17. Wise, R. E., and O'Brien, R. G.: Interpretation of the Intravenous Cholangiogram , J. A. M. A. 160:819, 1956.
A.M.A. Archives of Internal Medicine – American Medical Association
Published: Jun 1, 1958