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A Report on Animal Experiments with Griseofulvin: The Griseofulvin Content of Hair

A Report on Animal Experiments with Griseofulvin: The Griseofulvin Content of Hair Abstract During the early experimental studies of the effect of oral griseofulvin on Microsporum canis ringworm in guinea pigs (Gentles, 1958)4 it was observed that, approximately seven days after the first treatment, the fluorescence under Wood's light had cleared from the base of infected hairs. Microscopic examination showed that the fungus was confined to the fluorescent portion of the hair, and investigation of large numbers of epilated hairs and of hairs cut longitudinally in skin sections revealed that in certain of them, the tips of some of the fungal hyphae were malformed in a manner which was reminiscent of the effect of griseofulvin on susceptible fungi (Fig. 1). Because of this, and because the length of the uninvaded basal portions of the hairs (Fig. 2) corresponded approximately to the growth in length expected during the treatment period, it was postulated that griseofulvin given orally is incorporated in some way in References 1. Bedford, C.; Child, K. J., and Tomich, E. G.: Nature, London 184:364-365, 1959.Crossref 2. Bedford, C.; Busfield, D.; Child, K. J.; MacGregor, P. S., and Tomich, E. G., to be published. 3. Boothroyd, B.: Personal communication to the authors, 1959. 4. Gentles, J. C.: Nature, London 182:476-477, 1958.Crossref 5. Gentles, J. C.; Barnes, M. J., and Fantes, K. H.: Nature, London 183:256-257, 1959.Crossref 6. Muggleton, P. W.: Personal communication to the authors, 1959. 7. Wilson, J. W., in Therapy of Fungus Diseases , edited by Sternberg, T. H., and Newcomer, V. D., Boston, Little, Brown & Co., 1955, p. 27. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

A Report on Animal Experiments with Griseofulvin: The Griseofulvin Content of Hair

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Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1960.03730050059011
Publisher site
See Article on Publisher Site

Abstract

Abstract During the early experimental studies of the effect of oral griseofulvin on Microsporum canis ringworm in guinea pigs (Gentles, 1958)4 it was observed that, approximately seven days after the first treatment, the fluorescence under Wood's light had cleared from the base of infected hairs. Microscopic examination showed that the fungus was confined to the fluorescent portion of the hair, and investigation of large numbers of epilated hairs and of hairs cut longitudinally in skin sections revealed that in certain of them, the tips of some of the fungal hyphae were malformed in a manner which was reminiscent of the effect of griseofulvin on susceptible fungi (Fig. 1). Because of this, and because the length of the uninvaded basal portions of the hairs (Fig. 2) corresponded approximately to the growth in length expected during the treatment period, it was postulated that griseofulvin given orally is incorporated in some way in References 1. Bedford, C.; Child, K. J., and Tomich, E. G.: Nature, London 184:364-365, 1959.Crossref 2. Bedford, C.; Busfield, D.; Child, K. J.; MacGregor, P. S., and Tomich, E. G., to be published. 3. Boothroyd, B.: Personal communication to the authors, 1959. 4. Gentles, J. C.: Nature, London 182:476-477, 1958.Crossref 5. Gentles, J. C.; Barnes, M. J., and Fantes, K. H.: Nature, London 183:256-257, 1959.Crossref 6. Muggleton, P. W.: Personal communication to the authors, 1959. 7. Wilson, J. W., in Therapy of Fungus Diseases , edited by Sternberg, T. H., and Newcomer, V. D., Boston, Little, Brown & Co., 1955, p. 27.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: May 1, 1960

References