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A Reinvestigation of Solar Lentigines

A Reinvestigation of Solar Lentigines Abstract • Solar lentigines were reinvestigated by a number of different methods to gain a better perspective on their structure. In histologic sections and dopa preparations of split skin, large numbers of melanocytes were seen crowded at the base of the clubbed, budding rete ridges. In splitskin preparations, the scanning electron microscope showed complex systems of ridges, columns, and craters on the underside of the lentiginous epidermis. Oval bodies measuring 15 to 30 μ, with dendrites, were numerous at the apices of the complex epidermal ridges; these bodies were presumed to be melanocytes. In transmission electron micrographs of lentigines, the melanosome complexes inside the keratinocytes were much larger than those found in noninvolved skin. The complex and distinctive architecture of these maculae is probably the result of concurrent proliferation of melanocytes and keratinocytes. (Arch Dermatol 116:1151-1154, 1980) References 1. Cawley EP, Curtis AC: Lentigo senilis . Arch Dermatol Syphilol 62:635-641, 1950.Crossref 2. Hodgson C: Senile lentigo . Arch Dermatol 87:197-207, 1963.Crossref 3. Braun-Falco 0, Schoenfinius HH: Lentigo senilis . Hautarzt 22:277-283, 1971. 4. Beam WB: Senile freckles . JAMA 234:1059, 1975.Crossref 5. Lever W, Schaumburg-Lever G: Histopathology of the Skin , ed 5. Philadelphia, JB Lippincott Co, 1975, pp 646-679. 6. Mehregan AH: Lentigo senilis and its evolutions . J Invest Dermatol 65:429-433, 1975.Crossref 7. Roman NA: Orcein-hematoxylin in iodized ferric chloride as a stain for elastic fibers, with metanil yellow counterstaining . J Invest Dermatol 42:199-202, 1967. 8. Gomori G: Microscopic Histochemistry: Principles and Practice . Chicago, University of Chicago Press, 1952. 9. Roman NA, Ford DM, Montagna W: The demonstration of cutaneous nerves . J Invest Dermatol 53:328-331, 1969.Crossref 10. Russel NJ: Epidermal Ultrastructure During Wound Healing in Chick Embryos, thesis. Graduate School of the University of Minnesota, Minneapolis, 1972. 11. Millonig G: Further observations on a phosphate buffer for osmium solutions in fixation , in Breese SS Jr (ed): Fifth International Congress of Electron Microscopy . New York, Academic Press Inc, 1962, vol 2, pp P8-P9. 12. Spurr AR: A low-viscosity epoxy resin embedding medium for electron microscopy . J Ultrastruct Res 26:31-43, 1969.Crossref 13. Reynolds ES: The use of lead citrate at high pH as an electron opaque stain in electron microscopy . J Cell Biol 17:208-212, 1963.Crossref 14. Starrico RJ, Pinkus H: Quantitative and qualitative data on the pigment cells of adult human dermis . J Invest Dermatol 28:33-45, 1957. 15. Hu F: Aging of melanocytes . J Invest Dermatol 73:70-79, 1979.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

A Reinvestigation of Solar Lentigines

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Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1980.01640340061017
Publisher site
See Article on Publisher Site

Abstract

Abstract • Solar lentigines were reinvestigated by a number of different methods to gain a better perspective on their structure. In histologic sections and dopa preparations of split skin, large numbers of melanocytes were seen crowded at the base of the clubbed, budding rete ridges. In splitskin preparations, the scanning electron microscope showed complex systems of ridges, columns, and craters on the underside of the lentiginous epidermis. Oval bodies measuring 15 to 30 μ, with dendrites, were numerous at the apices of the complex epidermal ridges; these bodies were presumed to be melanocytes. In transmission electron micrographs of lentigines, the melanosome complexes inside the keratinocytes were much larger than those found in noninvolved skin. The complex and distinctive architecture of these maculae is probably the result of concurrent proliferation of melanocytes and keratinocytes. (Arch Dermatol 116:1151-1154, 1980) References 1. Cawley EP, Curtis AC: Lentigo senilis . Arch Dermatol Syphilol 62:635-641, 1950.Crossref 2. Hodgson C: Senile lentigo . Arch Dermatol 87:197-207, 1963.Crossref 3. Braun-Falco 0, Schoenfinius HH: Lentigo senilis . Hautarzt 22:277-283, 1971. 4. Beam WB: Senile freckles . JAMA 234:1059, 1975.Crossref 5. Lever W, Schaumburg-Lever G: Histopathology of the Skin , ed 5. Philadelphia, JB Lippincott Co, 1975, pp 646-679. 6. Mehregan AH: Lentigo senilis and its evolutions . J Invest Dermatol 65:429-433, 1975.Crossref 7. Roman NA: Orcein-hematoxylin in iodized ferric chloride as a stain for elastic fibers, with metanil yellow counterstaining . J Invest Dermatol 42:199-202, 1967. 8. Gomori G: Microscopic Histochemistry: Principles and Practice . Chicago, University of Chicago Press, 1952. 9. Roman NA, Ford DM, Montagna W: The demonstration of cutaneous nerves . J Invest Dermatol 53:328-331, 1969.Crossref 10. Russel NJ: Epidermal Ultrastructure During Wound Healing in Chick Embryos, thesis. Graduate School of the University of Minnesota, Minneapolis, 1972. 11. Millonig G: Further observations on a phosphate buffer for osmium solutions in fixation , in Breese SS Jr (ed): Fifth International Congress of Electron Microscopy . New York, Academic Press Inc, 1962, vol 2, pp P8-P9. 12. Spurr AR: A low-viscosity epoxy resin embedding medium for electron microscopy . J Ultrastruct Res 26:31-43, 1969.Crossref 13. Reynolds ES: The use of lead citrate at high pH as an electron opaque stain in electron microscopy . J Cell Biol 17:208-212, 1963.Crossref 14. Starrico RJ, Pinkus H: Quantitative and qualitative data on the pigment cells of adult human dermis . J Invest Dermatol 28:33-45, 1957. 15. Hu F: Aging of melanocytes . J Invest Dermatol 73:70-79, 1979.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Oct 1, 1980

References