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A Rapid Metabolic Screening Test to Evaluate Potential Cadaveric Kidney Donors

A Rapid Metabolic Screening Test to Evaluate Potential Cadaveric Kidney Donors A tetrazolium dye reduction test has been evaluated for use in assessing the suitability of cadaver kidneys for transplantation. The time required for a color change of a small cortical slice was measured. Nine human cadaveric kidney transplants were tested and the results generally paralleled the severity of the acute tubular necrosis present. In a simulated cadaver experiment with canine kidneys subjected to varying periods of ischemia, the tetrazolium test could identify kidneys which would not recover function. Its greatest potential value appears to be in the utilization of kidneys previously thought unsuitable. A favorable test result in a donor kidney which was subjected to 48 hours of severe shock and 36 hours of total anuria which was unresponsive to mannitol, resulted in a successful transplantation to a recipient who otherwise might have been denied a kidney. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

A Rapid Metabolic Screening Test to Evaluate Potential Cadaveric Kidney Donors

JAMA , Volume 201 (3) – Jul 17, 1967

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Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1967.03130030030007
Publisher site
See Article on Publisher Site

Abstract

A tetrazolium dye reduction test has been evaluated for use in assessing the suitability of cadaver kidneys for transplantation. The time required for a color change of a small cortical slice was measured. Nine human cadaveric kidney transplants were tested and the results generally paralleled the severity of the acute tubular necrosis present. In a simulated cadaver experiment with canine kidneys subjected to varying periods of ischemia, the tetrazolium test could identify kidneys which would not recover function. Its greatest potential value appears to be in the utilization of kidneys previously thought unsuitable. A favorable test result in a donor kidney which was subjected to 48 hours of severe shock and 36 hours of total anuria which was unresponsive to mannitol, resulted in a successful transplantation to a recipient who otherwise might have been denied a kidney.

Journal

JAMAAmerican Medical Association

Published: Jul 17, 1967

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