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ARTICLE JOURNAL CLUB A Randomized Trial of Nebulized 3% Hypertonic Saline With Epinephrine in the Treatment of Acute Bronchiolitis in the Emergency Department Simran Grewal, MD; Samina Ali, MD; Don W. McConnell, MD; Ben Vandermeer, MSc; Terry P. Klassen, MSc, MD Objective: To determine whether nebulized 3% hyper- Results: Forty-six patients were enrolled and evalu- tonic saline with epinephrine is more effective than nebu- ated. The 2 study groups had similar baseline character- lized 0.9% saline with epinephrine in the treatment of istics. The RACS from baseline to 120 minutes demon- bronchiolitis in the emergency department. strated no improvement in respiratory distress in the hypertonic saline group compared with the normal sa- Design: Randomized, double-blind, controlled trial. line control group. The change in oxygen saturation in the hypertonic saline group was not significant when com- Setting: Single-center urban pediatric emergency de- pared with the control group. Rates of admission and re- partment. turn to the emergency department were not different be- tween the 2 groups. Participants: Infants younger than 12 months with mild to moderate bronchiolitis. Conclusions: In the treatment of acute bronchiolitis, hy- Interventions: Patients were randomized to receive pertonic saline and epinephrine did not improve clini- nebulized
JAMA Pediatrics – American Medical Association
Published: Nov 1, 2009
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