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A Quantitative Investigation of Hippocampal Pyramidal Cell Size, Shape, and Variability of Orientation in Schizophrenia

A Quantitative Investigation of Hippocampal Pyramidal Cell Size, Shape, and Variability of... Abstract • Hippocampal abnormalities have been described in patients with schizophrenia, with disarray of pyramidal cells being one of the more intriguing findings. Controversy exists regarding whether disarray is present in the brains from schizophrenics in the Yakovlev collection at the Armed Forces Institute of Pathology, Washington, DC. We examined for disarray the CA1 region of the midhippocampus of 17 schizophrenics and 32 controls from this collection using computerized determination of neuronal angle and directional statistical analysis of the variability of neuronal angle. Neuronal area and shape were also assessed. We found no differences between patients and controls in these measures. Possible methodological reasons for the discrepancy between our and others' findings are discussed, as well as directions for further research into possible pathological study of the hippocampus and related structures in schizophrenia. References 1. Pribram KH. The hippocampal system and recombinant processing . In: Isaacson RL, Pribram KH, eds. The Hippocampus . New York, NY: Plenum Publishing Corp; 1986;4:329-370. 2. Gabriel M, Sparenborg, Stolar N. An executive function of the hippocampus: pathway selection for thalamic neuronal significance code . In: Isaacson RL, Pribram KH, eds. The Hippocampus . New York, NY: Plenum Publishing Corp; 1986;4:1-40. 3. Grey JA. Précis of the neuropsychology of anxiety: an enquiry into the functions of the septo-hippocampal system . Behav Brain Sciences . 1982;5:469-534.Crossref 4. Berger TW, Berry SD, Thompson RF. Role of the hippocampus in classical conditioning of aversive and appetitive behaviors . In: Isaacson RL, Pribram KH, eds. The Hippocampus . New York, NY: Plenum Publishing Corp; 1986;4:203-240. 5. Heath RG, Walker CF. Case report: correlation of deep and surface electroencephalograms with psychosis and hallucinations in schizophrenics: a report of two cases . Biol Psychiatry . 1985;20:669-674.Crossref 6. Stevens JR. Neuropathology of schizophrenia . Arch Gen Psychiatry . 1982;39:1131-1139.Crossref 7. Nieto D, Escobar A. Major psychoses . In: Minckler J, ed. Pathology of the Nervous System . New York, NY: McGraw-Hill International Book Co; 1972;3:2654-2665. 8. Bogerts B, Meertz E, Schonfeldt-Bausch R. Basal ganglia and limbic system pathology in schizophrenia: a morphometric study of brain volume and shrinkage . Arch Gen Psychiatry . 1985;42:784-791.Crossref 9. Falkai P, Bogerts B. Cell loss in the hippocampus of schizophrenics . Eur Arch Psychiatry Neurol Sci . 1986;236:154-161.Crossref 10. Roberts GW, Ferrier IN, Lee Y, Crow TJ, Johnstone EC, Owens DGC, Bacarese-Hamilton AJ, McGregor G, O'Shaughnessey D, Polak JM, Bloom SR. Peptides, the limbic lobe and schizophrenia . Brain Res . 1983;288:199-211.Crossref 11. Farmery SM, Owen F, Poulter M, Crow TJ. Reduced high affinity cholecystokinin binding in hippocampus and frontal cortex of schizophrenic patients . Life Sci . 1985;36:473-477.Crossref 12. Jeste DV, Lohr JB. Hippocampal pathology in schizophrenia. Presented at the 25th Annual Meeting of the American College of Neuropsychopharmacology; December 9, 1986; Washington, DC. 13. Scheibel AB, Kovelman JA. Disorientation of the hippocampal pyramidal cell and its processes in the schizophrenic patient . Biol Psychiatry . 1981;16:101-102. 14. Kovelman JA, Scheibel AB. A neurohistological correlate of schizophrenia . Biol Psychiatry . 1984;19:1601-1621. 15. Altshuler LL, Conrad A, Kovelman JA, Scheibel A. Hippocampal pyramidal cell orientation in schizophrenia: a controlled neurohistologic study of the Yakovlev collection . Arch Gen Psychiatry . 1987;44:1094-1098.Crossref 16. Weinberger DR, Luchins DJ, Kleinman JE, Wyatt RJ. The hippocampus in schizophrenia: a controlled postmortem study. Presented at the 35th Annual Society of Biological Psychiatry Annual Meeting; 1980; Boston, Mass. 17. Spitzer RL, Endicott J, Robins E. Research Diagnostic Criteria for a Selected Group of Functional Disorders . 3rd ed. New York, NY: New York State Psychiatric Institute, Biometrics Research Division; 1978. 18. Lorente de No R. Studies on the structure of the cerebral cortex, II: continuation of the study of the ammonic system . J Psychol Neurol . 1934;46:113-177. 19. Armstrong E, Frost GT. Evolution of the primate subiculum . Soc Neurosci Abstr . 1988;14:527. 20. Loats HL, Whitehouse PS, Lloyd DL, Altschuler RS, Price DL. A computer image analysis system for neuron morphometry . Soc Neurosci Abstr . 1986;12:82. 21. Press WH. Numerical Recipes: The Art of Scientific Computing . New York, NY: Cambridge University Press; 1956. 22. Mardia KV. Statistics of Directional Data . Orlando, Fla: Academic Press Inc; 1972. 23. Benes FM, Paskevich PA, Davidson J, Domesick VB. The effects of haloperidol on synaptic patterns in the rat striatum . Brain Res . 1985;329:265-274.Crossref 24. Jellinger K. Neuropathologic findings after neuroleptic long-term therapy . In: Roizin L, Shiraki H, Grcebic N, eds. Neurotoxicology . New York, NY: Raven Press; 1977:25-42. 25. Greenblatt M, Solomon H. Neuropathologic lesions following lobotomy . In: Greenblatt M, Solomon H, eds. Frontal Lobes and Schizophrenia . New York, NY: Springer Publishing Co Inc; 1953:307-324. 26. Roizin L. Histopathologic observations in schizophrenia: including effects of somatic and biochemical therapies . In: Minckler J, ed. Pathology of the Nervous System . New York, NY: McGraw-Hill International Book Co; 1972:2670-2677. 27. Carpenter MB. Core Text of Neuroanatomy . 2nd ed. Baltimore, Md: Williams & Wilkins; 1978:26. 28. Shelton RC, Weinberger DR. X-ray computerized tomography studies in schizophrenia: a review and synthesis . In: Nasrallah HA, Weinberger DR, eds. Handbook of Schizophrenia, I: The Neurology of Schizophrenia . Amsterdam, the Netherlands: Elsevier Science Publishers; 1986:207-250. 29. Brown R, Colter N, Corsellis JAN, Crow TJ, Frith CD, Jagoe R, Johnstone EC, Marsh L. Postmortem evidence of structural brain changes in schizophrenia: differences in brain weight, temporal horn area, and parahippocampal gyrus compared with affective disorder . Arch Gen Psychiatry . 1986;43:36-42.Crossref 30. Swanson LW. Normal hippocampal circuitry: anatomy . Neurosciences Res Prog Bull . 1982;20:624-634. 31. Blackstad TW. On the termination of some afferents to the hippocampus and fascia dentata: an experimental study in the rat . Acta Anat . 1958;35:202-214.Crossref 32. Hjorth-Simonsen A. Projections of the lateral part of the entorhinal area of the hippocampus and fascia dentata . J Comp Neurol 1972;146:219-232.Crossref 33. Hjorth-Simonsen A, Jenne B. Origin and termination of the hippocampal perforant path in the rat studied by silver impregnation . J Comp Neurol . 1972;144:215-232.Crossref 34. Van Hoesen GW, Pardya DN. Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey, I: temporal lobe afferents . Brain Res . 1975;95:1-24.Crossref 35. Van Hoesen GW. The parahippocampal gyrus: new observations regarding its cortical connections in the monkey . TINS . 1982;5:345-350. 36. Rosene DL, Van Hoesen GW. Hippocampal efferents reach widespread areas of cerebral cortex and amygdala in the rhesus monkey . Science . 1977;198:315-317.Crossref 37. Witter MP, Groenewegen HJ. Connections of the parahippocampal cortex in the cat, III: cortical and thalamic efferents . J Comp Neurol . 1986;252:1-31.Crossref 38. Descarries L, Lemay B, Doucet G, Berger B. Regional and laminar density of the dopamine innervation in adult rat cerebral cortex . Neuroscience . 1987;21:807-824.Crossref 39. Jakob H, Beckmann H. Prenatal developmental disturbances in the limbic allocortex in schizophrenics . J Neural Transm . 1986;65:303-326.Crossref 40. Colter N, Battal S, Crow TJ, Johnstone EC, Brown R, Bruton C. White matter reduction in the parahippocampal gyrus of patients with schizophrenia . Arch Gen Psychiatry . 1987;44:1023.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of General Psychiatry American Medical Association

A Quantitative Investigation of Hippocampal Pyramidal Cell Size, Shape, and Variability of Orientation in Schizophrenia

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Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0003-990X
eISSN
1598-3636
DOI
10.1001/archpsyc.1989.01810110069010
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Abstract

Abstract • Hippocampal abnormalities have been described in patients with schizophrenia, with disarray of pyramidal cells being one of the more intriguing findings. Controversy exists regarding whether disarray is present in the brains from schizophrenics in the Yakovlev collection at the Armed Forces Institute of Pathology, Washington, DC. We examined for disarray the CA1 region of the midhippocampus of 17 schizophrenics and 32 controls from this collection using computerized determination of neuronal angle and directional statistical analysis of the variability of neuronal angle. Neuronal area and shape were also assessed. We found no differences between patients and controls in these measures. Possible methodological reasons for the discrepancy between our and others' findings are discussed, as well as directions for further research into possible pathological study of the hippocampus and related structures in schizophrenia. References 1. Pribram KH. The hippocampal system and recombinant processing . In: Isaacson RL, Pribram KH, eds. The Hippocampus . New York, NY: Plenum Publishing Corp; 1986;4:329-370. 2. Gabriel M, Sparenborg, Stolar N. An executive function of the hippocampus: pathway selection for thalamic neuronal significance code . In: Isaacson RL, Pribram KH, eds. The Hippocampus . New York, NY: Plenum Publishing Corp; 1986;4:1-40. 3. Grey JA. Précis of the neuropsychology of anxiety: an enquiry into the functions of the septo-hippocampal system . Behav Brain Sciences . 1982;5:469-534.Crossref 4. Berger TW, Berry SD, Thompson RF. Role of the hippocampus in classical conditioning of aversive and appetitive behaviors . In: Isaacson RL, Pribram KH, eds. The Hippocampus . New York, NY: Plenum Publishing Corp; 1986;4:203-240. 5. Heath RG, Walker CF. Case report: correlation of deep and surface electroencephalograms with psychosis and hallucinations in schizophrenics: a report of two cases . Biol Psychiatry . 1985;20:669-674.Crossref 6. Stevens JR. Neuropathology of schizophrenia . Arch Gen Psychiatry . 1982;39:1131-1139.Crossref 7. Nieto D, Escobar A. Major psychoses . In: Minckler J, ed. Pathology of the Nervous System . New York, NY: McGraw-Hill International Book Co; 1972;3:2654-2665. 8. Bogerts B, Meertz E, Schonfeldt-Bausch R. Basal ganglia and limbic system pathology in schizophrenia: a morphometric study of brain volume and shrinkage . Arch Gen Psychiatry . 1985;42:784-791.Crossref 9. Falkai P, Bogerts B. Cell loss in the hippocampus of schizophrenics . Eur Arch Psychiatry Neurol Sci . 1986;236:154-161.Crossref 10. Roberts GW, Ferrier IN, Lee Y, Crow TJ, Johnstone EC, Owens DGC, Bacarese-Hamilton AJ, McGregor G, O'Shaughnessey D, Polak JM, Bloom SR. Peptides, the limbic lobe and schizophrenia . Brain Res . 1983;288:199-211.Crossref 11. Farmery SM, Owen F, Poulter M, Crow TJ. Reduced high affinity cholecystokinin binding in hippocampus and frontal cortex of schizophrenic patients . Life Sci . 1985;36:473-477.Crossref 12. Jeste DV, Lohr JB. Hippocampal pathology in schizophrenia. Presented at the 25th Annual Meeting of the American College of Neuropsychopharmacology; December 9, 1986; Washington, DC. 13. Scheibel AB, Kovelman JA. Disorientation of the hippocampal pyramidal cell and its processes in the schizophrenic patient . Biol Psychiatry . 1981;16:101-102. 14. Kovelman JA, Scheibel AB. A neurohistological correlate of schizophrenia . Biol Psychiatry . 1984;19:1601-1621. 15. Altshuler LL, Conrad A, Kovelman JA, Scheibel A. Hippocampal pyramidal cell orientation in schizophrenia: a controlled neurohistologic study of the Yakovlev collection . Arch Gen Psychiatry . 1987;44:1094-1098.Crossref 16. Weinberger DR, Luchins DJ, Kleinman JE, Wyatt RJ. The hippocampus in schizophrenia: a controlled postmortem study. Presented at the 35th Annual Society of Biological Psychiatry Annual Meeting; 1980; Boston, Mass. 17. Spitzer RL, Endicott J, Robins E. Research Diagnostic Criteria for a Selected Group of Functional Disorders . 3rd ed. New York, NY: New York State Psychiatric Institute, Biometrics Research Division; 1978. 18. Lorente de No R. Studies on the structure of the cerebral cortex, II: continuation of the study of the ammonic system . J Psychol Neurol . 1934;46:113-177. 19. Armstrong E, Frost GT. Evolution of the primate subiculum . Soc Neurosci Abstr . 1988;14:527. 20. Loats HL, Whitehouse PS, Lloyd DL, Altschuler RS, Price DL. A computer image analysis system for neuron morphometry . Soc Neurosci Abstr . 1986;12:82. 21. Press WH. Numerical Recipes: The Art of Scientific Computing . New York, NY: Cambridge University Press; 1956. 22. Mardia KV. Statistics of Directional Data . Orlando, Fla: Academic Press Inc; 1972. 23. Benes FM, Paskevich PA, Davidson J, Domesick VB. The effects of haloperidol on synaptic patterns in the rat striatum . Brain Res . 1985;329:265-274.Crossref 24. Jellinger K. Neuropathologic findings after neuroleptic long-term therapy . In: Roizin L, Shiraki H, Grcebic N, eds. Neurotoxicology . New York, NY: Raven Press; 1977:25-42. 25. Greenblatt M, Solomon H. Neuropathologic lesions following lobotomy . In: Greenblatt M, Solomon H, eds. Frontal Lobes and Schizophrenia . New York, NY: Springer Publishing Co Inc; 1953:307-324. 26. Roizin L. Histopathologic observations in schizophrenia: including effects of somatic and biochemical therapies . In: Minckler J, ed. Pathology of the Nervous System . New York, NY: McGraw-Hill International Book Co; 1972:2670-2677. 27. Carpenter MB. Core Text of Neuroanatomy . 2nd ed. Baltimore, Md: Williams & Wilkins; 1978:26. 28. Shelton RC, Weinberger DR. X-ray computerized tomography studies in schizophrenia: a review and synthesis . In: Nasrallah HA, Weinberger DR, eds. Handbook of Schizophrenia, I: The Neurology of Schizophrenia . Amsterdam, the Netherlands: Elsevier Science Publishers; 1986:207-250. 29. Brown R, Colter N, Corsellis JAN, Crow TJ, Frith CD, Jagoe R, Johnstone EC, Marsh L. Postmortem evidence of structural brain changes in schizophrenia: differences in brain weight, temporal horn area, and parahippocampal gyrus compared with affective disorder . Arch Gen Psychiatry . 1986;43:36-42.Crossref 30. Swanson LW. Normal hippocampal circuitry: anatomy . Neurosciences Res Prog Bull . 1982;20:624-634. 31. Blackstad TW. On the termination of some afferents to the hippocampus and fascia dentata: an experimental study in the rat . Acta Anat . 1958;35:202-214.Crossref 32. Hjorth-Simonsen A. Projections of the lateral part of the entorhinal area of the hippocampus and fascia dentata . J Comp Neurol 1972;146:219-232.Crossref 33. Hjorth-Simonsen A, Jenne B. Origin and termination of the hippocampal perforant path in the rat studied by silver impregnation . J Comp Neurol . 1972;144:215-232.Crossref 34. Van Hoesen GW, Pardya DN. Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey, I: temporal lobe afferents . Brain Res . 1975;95:1-24.Crossref 35. Van Hoesen GW. The parahippocampal gyrus: new observations regarding its cortical connections in the monkey . TINS . 1982;5:345-350. 36. Rosene DL, Van Hoesen GW. Hippocampal efferents reach widespread areas of cerebral cortex and amygdala in the rhesus monkey . Science . 1977;198:315-317.Crossref 37. Witter MP, Groenewegen HJ. Connections of the parahippocampal cortex in the cat, III: cortical and thalamic efferents . J Comp Neurol . 1986;252:1-31.Crossref 38. Descarries L, Lemay B, Doucet G, Berger B. Regional and laminar density of the dopamine innervation in adult rat cerebral cortex . Neuroscience . 1987;21:807-824.Crossref 39. Jakob H, Beckmann H. Prenatal developmental disturbances in the limbic allocortex in schizophrenics . J Neural Transm . 1986;65:303-326.Crossref 40. Colter N, Battal S, Crow TJ, Johnstone EC, Brown R, Bruton C. White matter reduction in the parahippocampal gyrus of patients with schizophrenia . Arch Gen Psychiatry . 1987;44:1023.Crossref

Journal

Archives of General PsychiatryAmerican Medical Association

Published: Nov 1, 1989

References