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A Pink-Pigmented, Oxidative, Nonmotile Bacterium as a Cause of Opportunistic Infections

A Pink-Pigmented, Oxidative, Nonmotile Bacterium as a Cause of Opportunistic Infections Abstract • We describe two cases of bacteremia due to a pink-pigmented, oxidative, nonmotile, gram-negative, rod-shaped organism. One case occurred in a febrile neutropenic patient and another in a chronically debilitated patient with pancreatic abscess. The first patient was cured with gentamicin and ticarcillin, but the second patient died while receiving cefamandole therapy. The organisms described here are similar to Methylobacterium mesophilicum (Pseudomonas mesophilica) and the "unnamed taxon" organisms. A major difference from M mesophilicum is the lack of methanol utilization. Further distinctions between our isolates and M mesophilicum are the lack of flagella in our organisms, growth at 42°C, growth on MacConkey's agar, lack of acetamide assimilation, and citrate utilization. The lack of flagella is the principle difference between our isolates and those in the unnamed taxon. Both of the isolates were resistant to the cephalosporins, but susceptible to the aminoglycosides, ticarcillin-clavulanic acid, sulfamethoxazole and trimethoprim, and imipenem. With the growing population of immunocompromised and chronically ill patients, these organisms may emerge as important pathogens. (Arch Intern Med. 1989;149:1449-1451) References 1. Patt TE, Cole GC, Hanson RS. Methylobacterium: a new genus of facultatively methylotrophic bacteria . Int J Syst Bacteriol . 1976;26:226-229.Crossref 2. Green PN, Bousfield IJ. Emendation of Methylobacterium (Patt, Cole, and Hanson 1976); Methylobacterium rhodinum (Heumann 1962) comb nov corrig; Methylobacterium radiotolerans (Ito and Iizuka 1971) comb nov corrig; and Methylobacterium mesophilicum (Austin and Goodfellow 1979) comb nov . Int J Syst Bacteriol . 1983;33:875-877.Crossref 3. Urakami T, Komagata K. Protomonas: a new genus of facultatively methylotrophic bacteria . Int J Syst Bacteriol . 1984;34:188-201.Crossref 4. Austin B, Goodfellow M. Pseudomonas mesophilica: a new species of pink bacteria isolated from leaf surfaces . Int J Syst Bacteriol . 1979;29:373-378.Crossref 5. Gilardi GL, Faur YC. Pseudomonas mesophilica and an unnamed taxon: clinical isolates of pink-pigmented oxidative bacteria . J Clin Microbiol . 1984;20:626-629. 6. Bassalik K. Uber die Verarbeitung der Oxalsaure durch Bacillus extorquens n sp . Jahrb Wiss Bot . 1913;53:255-302. 7. Green PN, Bousfield IJ, Hood D. Three new Methylobacterium species: M rhodesianum sp nov, M zatmanii sp nov, and M fujisawaense sp nov . Int J Syst Bacteriol . 1988;38:124-127.Crossref 8. Lambert WC, Pathan AK, Imaeda T, Kaminski ZC, Reichman LB. Culture of Vibrio extorquens from severe, chronic skin ulcers in a Puerto Rican woman . J Am Acad Dermatol . 1983;9:262-268.Crossref 9. Smith SM, Eng RHK, Forrester C. Pseudomonas mesophilica infections in humans . J Clin Microbiol . 1985;21:314-317. 10. Gilchrist MJR, Kraft JA, Hammond JG, Connelly BL, Myers MG. Detection of Pseudomonas mesophilica as a source of nosocomial infections in a bone marrow transplant unit . J Clin Microbiol . 1986;23:1052-1055. 11. Odugbemi T, Nwofor C, Joiner K. Isolation of an unindentified pink-pigmented bacterium in a clinical specimen . J Clin Microbiol . 1988;26:1072-1073. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

A Pink-Pigmented, Oxidative, Nonmotile Bacterium as a Cause of Opportunistic Infections

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Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1989.00390060153036
Publisher site
See Article on Publisher Site

Abstract

Abstract • We describe two cases of bacteremia due to a pink-pigmented, oxidative, nonmotile, gram-negative, rod-shaped organism. One case occurred in a febrile neutropenic patient and another in a chronically debilitated patient with pancreatic abscess. The first patient was cured with gentamicin and ticarcillin, but the second patient died while receiving cefamandole therapy. The organisms described here are similar to Methylobacterium mesophilicum (Pseudomonas mesophilica) and the "unnamed taxon" organisms. A major difference from M mesophilicum is the lack of methanol utilization. Further distinctions between our isolates and M mesophilicum are the lack of flagella in our organisms, growth at 42°C, growth on MacConkey's agar, lack of acetamide assimilation, and citrate utilization. The lack of flagella is the principle difference between our isolates and those in the unnamed taxon. Both of the isolates were resistant to the cephalosporins, but susceptible to the aminoglycosides, ticarcillin-clavulanic acid, sulfamethoxazole and trimethoprim, and imipenem. With the growing population of immunocompromised and chronically ill patients, these organisms may emerge as important pathogens. (Arch Intern Med. 1989;149:1449-1451) References 1. Patt TE, Cole GC, Hanson RS. Methylobacterium: a new genus of facultatively methylotrophic bacteria . Int J Syst Bacteriol . 1976;26:226-229.Crossref 2. Green PN, Bousfield IJ. Emendation of Methylobacterium (Patt, Cole, and Hanson 1976); Methylobacterium rhodinum (Heumann 1962) comb nov corrig; Methylobacterium radiotolerans (Ito and Iizuka 1971) comb nov corrig; and Methylobacterium mesophilicum (Austin and Goodfellow 1979) comb nov . Int J Syst Bacteriol . 1983;33:875-877.Crossref 3. Urakami T, Komagata K. Protomonas: a new genus of facultatively methylotrophic bacteria . Int J Syst Bacteriol . 1984;34:188-201.Crossref 4. Austin B, Goodfellow M. Pseudomonas mesophilica: a new species of pink bacteria isolated from leaf surfaces . Int J Syst Bacteriol . 1979;29:373-378.Crossref 5. Gilardi GL, Faur YC. Pseudomonas mesophilica and an unnamed taxon: clinical isolates of pink-pigmented oxidative bacteria . J Clin Microbiol . 1984;20:626-629. 6. Bassalik K. Uber die Verarbeitung der Oxalsaure durch Bacillus extorquens n sp . Jahrb Wiss Bot . 1913;53:255-302. 7. Green PN, Bousfield IJ, Hood D. Three new Methylobacterium species: M rhodesianum sp nov, M zatmanii sp nov, and M fujisawaense sp nov . Int J Syst Bacteriol . 1988;38:124-127.Crossref 8. Lambert WC, Pathan AK, Imaeda T, Kaminski ZC, Reichman LB. Culture of Vibrio extorquens from severe, chronic skin ulcers in a Puerto Rican woman . J Am Acad Dermatol . 1983;9:262-268.Crossref 9. Smith SM, Eng RHK, Forrester C. Pseudomonas mesophilica infections in humans . J Clin Microbiol . 1985;21:314-317. 10. Gilchrist MJR, Kraft JA, Hammond JG, Connelly BL, Myers MG. Detection of Pseudomonas mesophilica as a source of nosocomial infections in a bone marrow transplant unit . J Clin Microbiol . 1986;23:1052-1055. 11. Odugbemi T, Nwofor C, Joiner K. Isolation of an unindentified pink-pigmented bacterium in a clinical specimen . J Clin Microbiol . 1988;26:1072-1073.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jun 1, 1989

References