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A New Preparation for Gastric Secretory Studies in Dogs: Transplantation of the Autologous and Homologous Total Stomachs

A New Preparation for Gastric Secretory Studies in Dogs: Transplantation of the Autologous and... Abstract PROGRESS with homotransplantation and isolated perfusion of stomach preparations has been made, but each method has its limitations. Prolonged survival of homografts is difficult to obtain. Furthermore, some drugs administered to prevent rejection interfere with normal gastric secretions. Isolated perfusion preparations are useful, but pose many technical problems.1 Although total, or partial stomach transplantation experiments and experiments of isolated gastric perfusions are not recent developments, the results have never been completely satisfactory.2,3 With the recent development of a technic which facilitates the anastomosis of small vessels, however, the number of stomach transplantation experiments undertaken has increased.4-9 In the study of homotransplantation of the distal half of the stomach by Thompson et al, 31 homografts receiving immunosuppressive drugs had an average survival of 12.7 days.8 Unfortunately, other investigators have not mentioned the average number of survival days in their reports. Experiments of isolated gastric perfusions have been References 1. Salmon, P.A., and Assimacopoulos, CA.: Perfusion of the Isolated Canine Stomach , J Surg Res 4:339-348 ( (Aug) ) 1964.Crossref 2. Ivy, A.C., and Farrell, J.I.: Contributions to the Physiology of Gastric Secretion: Proof of a Humoral Mechanism: A New Procedure for the Study of Gastric Physiology , Amer J Physiol 74:639-649 ( (Nov) ) 1925. 3. Lim, R.K.S.; Loo, C.T.; and Liu, A.C.: Observation on the Secretion of the Transplanted Stomach , Chin J Physiol 1:51-62 ( (Jan) ) 1927. 4. Lillehei, R.C.; Longerbeam, J.K.; and Scott, W.R.: Whole Organ Grafts of the Stomach , JAMA 183:861-865 ( (March) ) 1963.Crossref 5. Hirota, L., et al: A Method for Transplanting Gastric Pouches , Surgery 57:876-885 ( (June) ) 1965. 6. Assimacopoulos, C.A., and Salmon, P.A.: Homotransplantation of the Canine Stomach: Preliminary Report , Surgery 57:714-720 ( (May) ) 1965. 7. Salmon, P.A., and Assimacopoulos, C.A.: Gastric Homotransplantation in Dogs: Response to Histamine and Meat Stimulation and Immunosuppressive Therapy With Azathioprine and Prednisolone , Ann Surg 162:825-836 ( (Nov) ) 1965.Crossref 8. Thompson, J.C., et al: Studies on the Humoral Control of Gastric Secretion in Dogs With Autogenous and Homotransplanted Antral and Fundic Pouches , Surgery 58:84-109 ( (July) ) 1965. 9. Davidson, W.D., et al: Dose-Response Curves of Denervated Autogenous and Homotransplanted Canine Fundic Pouches Stimulated With Purified Gastrin and Histamine , Gastroenterology 51:180-192 ( (Aug) ) 1966. 10. Dale, H.H., and Feldberg, W.: The Chemical Transmitter of Vagus Effects to the Stomach , J Physiol 81:320-334 ( (June) ) 1934. 11. Kawasake, G.: Über die Bewegung und die Entleerung des Inhaltes des ausgeschnittenem durchgeblutetem Magens , Jap J Med Sci Biol 6( (pt 3) :140-141 (Sept) 1940. 12. Barlow, T.E.; Bentley, F.H.; and Walder, D.N.: Arteries, Veins, and Arteriovenous Anastomoses in the Human Stomach . Surg Gynec Obstet 93:657-671 ( (Dec) ) 1951. 13. Moody, F.G.; Gilder, H.; and Beal, J.M.: Perfusion Secretory Studies of the Isolated Canine Stomach , Surg Forum 13:282-284, 1962. 14. Eisenberg, M.M.; Schapiro, H.; and Wood-ward, E.R.: A Technique for Construction and Perfusion of an Isolated Gastric Pouch , Surg Forum 14:320-322, 1963. 15. Nakayama, K., et al: A Simple New Apparatus for Small Vessel Anastomosis (Free Autograft of the Sigmoid Included) , Surg 52:918-931 ( (Dec) ) 1962. 16. Odaka, M.: Free-Autograft of the Intestine for Corrosive Stricture of the Esophagus, With Particular Reference to the Operative Method , Jap J Thorac Surg 12:198-225 ( (March) ) 1964. 17. Fletcher, T.L., et al: A New Preparation of Gastrin: Preliminary Characterization , Nature (London) 190:448 ( (April 29) ) 1961.Crossref 18. Babkin, B.P.; Schachter, M.; and Nisse, R.: Further Studies on the Relationship Between the Vagal Secretory Function and the Chemical Phase of Gastric Secretion , Clinics 3:494-505 ( (Oct) ) 1944. 19. Schachter, M.: Anesthesia and Gastric Secretion , Amer J Physiol , 156:248-255 ( (Feb) ) 1949. 20. Bennett, A.: Effect of Gastrin on Isolated Smooth Muscle Preparations , Nature (London) 208:170-173 ( (Oct) ) 1965.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

A New Preparation for Gastric Secretory Studies in Dogs: Transplantation of the Autologous and Homologous Total Stomachs

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Publisher
American Medical Association
Copyright
Copyright © 1968 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1968.01330240048011
Publisher site
See Article on Publisher Site

Abstract

Abstract PROGRESS with homotransplantation and isolated perfusion of stomach preparations has been made, but each method has its limitations. Prolonged survival of homografts is difficult to obtain. Furthermore, some drugs administered to prevent rejection interfere with normal gastric secretions. Isolated perfusion preparations are useful, but pose many technical problems.1 Although total, or partial stomach transplantation experiments and experiments of isolated gastric perfusions are not recent developments, the results have never been completely satisfactory.2,3 With the recent development of a technic which facilitates the anastomosis of small vessels, however, the number of stomach transplantation experiments undertaken has increased.4-9 In the study of homotransplantation of the distal half of the stomach by Thompson et al, 31 homografts receiving immunosuppressive drugs had an average survival of 12.7 days.8 Unfortunately, other investigators have not mentioned the average number of survival days in their reports. Experiments of isolated gastric perfusions have been References 1. Salmon, P.A., and Assimacopoulos, CA.: Perfusion of the Isolated Canine Stomach , J Surg Res 4:339-348 ( (Aug) ) 1964.Crossref 2. Ivy, A.C., and Farrell, J.I.: Contributions to the Physiology of Gastric Secretion: Proof of a Humoral Mechanism: A New Procedure for the Study of Gastric Physiology , Amer J Physiol 74:639-649 ( (Nov) ) 1925. 3. Lim, R.K.S.; Loo, C.T.; and Liu, A.C.: Observation on the Secretion of the Transplanted Stomach , Chin J Physiol 1:51-62 ( (Jan) ) 1927. 4. Lillehei, R.C.; Longerbeam, J.K.; and Scott, W.R.: Whole Organ Grafts of the Stomach , JAMA 183:861-865 ( (March) ) 1963.Crossref 5. Hirota, L., et al: A Method for Transplanting Gastric Pouches , Surgery 57:876-885 ( (June) ) 1965. 6. Assimacopoulos, C.A., and Salmon, P.A.: Homotransplantation of the Canine Stomach: Preliminary Report , Surgery 57:714-720 ( (May) ) 1965. 7. Salmon, P.A., and Assimacopoulos, C.A.: Gastric Homotransplantation in Dogs: Response to Histamine and Meat Stimulation and Immunosuppressive Therapy With Azathioprine and Prednisolone , Ann Surg 162:825-836 ( (Nov) ) 1965.Crossref 8. Thompson, J.C., et al: Studies on the Humoral Control of Gastric Secretion in Dogs With Autogenous and Homotransplanted Antral and Fundic Pouches , Surgery 58:84-109 ( (July) ) 1965. 9. Davidson, W.D., et al: Dose-Response Curves of Denervated Autogenous and Homotransplanted Canine Fundic Pouches Stimulated With Purified Gastrin and Histamine , Gastroenterology 51:180-192 ( (Aug) ) 1966. 10. Dale, H.H., and Feldberg, W.: The Chemical Transmitter of Vagus Effects to the Stomach , J Physiol 81:320-334 ( (June) ) 1934. 11. Kawasake, G.: Über die Bewegung und die Entleerung des Inhaltes des ausgeschnittenem durchgeblutetem Magens , Jap J Med Sci Biol 6( (pt 3) :140-141 (Sept) 1940. 12. Barlow, T.E.; Bentley, F.H.; and Walder, D.N.: Arteries, Veins, and Arteriovenous Anastomoses in the Human Stomach . Surg Gynec Obstet 93:657-671 ( (Dec) ) 1951. 13. Moody, F.G.; Gilder, H.; and Beal, J.M.: Perfusion Secretory Studies of the Isolated Canine Stomach , Surg Forum 13:282-284, 1962. 14. Eisenberg, M.M.; Schapiro, H.; and Wood-ward, E.R.: A Technique for Construction and Perfusion of an Isolated Gastric Pouch , Surg Forum 14:320-322, 1963. 15. Nakayama, K., et al: A Simple New Apparatus for Small Vessel Anastomosis (Free Autograft of the Sigmoid Included) , Surg 52:918-931 ( (Dec) ) 1962. 16. Odaka, M.: Free-Autograft of the Intestine for Corrosive Stricture of the Esophagus, With Particular Reference to the Operative Method , Jap J Thorac Surg 12:198-225 ( (March) ) 1964. 17. Fletcher, T.L., et al: A New Preparation of Gastrin: Preliminary Characterization , Nature (London) 190:448 ( (April 29) ) 1961.Crossref 18. Babkin, B.P.; Schachter, M.; and Nisse, R.: Further Studies on the Relationship Between the Vagal Secretory Function and the Chemical Phase of Gastric Secretion , Clinics 3:494-505 ( (Oct) ) 1944. 19. Schachter, M.: Anesthesia and Gastric Secretion , Amer J Physiol , 156:248-255 ( (Feb) ) 1949. 20. Bennett, A.: Effect of Gastrin on Isolated Smooth Muscle Preparations , Nature (London) 208:170-173 ( (Oct) ) 1965.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Jun 1, 1968

References