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A Morphometric and Histologic Study of the Scalp in Psoriasis: Paradoxical Sebaceous Gland Atrophy and Decreased Hair Shaft Diameters Without Alopecia

A Morphometric and Histologic Study of the Scalp in Psoriasis: Paradoxical Sebaceous Gland... Abstract • A histologic study was designed to evaluate the pilosebaceous unit of the scalp in nonpustular patch- and plaque-stage psoriasis. Punch biopsy specimens from involved and uninvolved areas of 28 patients were sectioned in a horizontal plane for qualitative and quantitative study. All samples were evaluated in a blind mode, and data were analyzed for statistical significance. There was no evidence for alopecia of any type. Sebaceous gland atrophy was a frequent concomitant in the psoriatic lesion, with probable down-sizing of the hair follicle and thinner hair shafts. Paradoxical sebaceous gland atrophy and down-sized hair follicles in psoriasis may be due to possible inhibiting effects of yet unidentified factors produced by the epidermal lesion. (Arch Dermatol. 1989;125:639-642) References 1. Shahrad P, Marks R. Hair follicle kinetics in psoriasis . Br J Dermatol . 1976;94:7-12.Crossref 2. Comaish S. Autoradiographic studies of hair growth in various dermatoses: investigation of a possible circadian rhythm in human hair growth . Br J Dermatol . 1969;81:282-283. 3. Katsuoka K, Schell H, Deinlein E, Hornstein OP. Cell kinetics in the human anagen hair follicle . Dermatologica . 1987;174:105-109.Crossref 4. Wyatt EH, Bottoms E, Comaish S. Abnormal hair shafts in psoriasis on scanning electron microscopy . Br J Dermatol . 1972; 87:368-373.Crossref 5. Wyatt EH, Roggott J. The influence of psoriasis on hair diameter . Br J Dermatol . 1981;105:349-350. 6. Headington JT. Transverse microscopic anatomy of the human scalp . Arch Dermatol . 1984;120:448-456.Crossref 7. Shuster S. Psoriatic alopecia . Br J Dermatol . 1972;87:73-77.Crossref 8. Braun-Falco O, Heilgemeir GP, Lincke-Plewig H. Histologische Differentialdiagnose von Psoriasis vulgaris and seborrhoischem Ekzem des Kapillitium . Hautarzt . 1979;30:478-483. 9. Braun-Falco O, Rassner B. Haarwurzelmuster bei Psoriasis vulgaris der Kopfhaut . Arch Klin Exp Dermatol . 1966;225:42-48.Crossref 10. Foreman MI, Picton W, Kukowiecki GA, Clark C. The effect of topical crude coal tar treatment on unstimulated hairless hamster skin . Br J Dermatol . 1979;100:707-715.Crossref 11. Altmeyer P. Ein Beitrag zur Histologie der von Kortikoidexterna verursachten Hautveränderungen . Hautarzt . 1977;28:83-88. 12. Nanney LB, Migid M, Stoscheck CM, King LE. Comparison of epidermal growth factor binding and receptor distribution in normal human epidermis and epidermal appendages . J Invest Dermatol . 1984;83:385-393.Crossref 13. Green MR, Couchman JR. Differences in human skin between the epidermal growth factor receptor distribution detected by EGF binding and monoclonal antibody recognition . J Invest Dermatol . 1985;85:239-245.Crossref 14. Nanney LB, Stoscheck CM, Magid M, King LE. Altered 125I-Epidermoid growth factor binding and receptor distribution in psoriasis . J Invest Dermatol . 1986;86:260-265.Crossref 15. Elder JT, Fisher GJ, Lindquist PB, et al. Overexpression of TGF-α, but not TGF-β, in psoriasis epidermis: potential role of phospholipase C . Science . 1989;243:811-814.Crossref 16. Moore GPM, Panaretto BA, Carter NB. Epidermal hyperplasia and wool follicle regression in sheep infused with epidermal growth factor . J Invest Dermatol . 1985;84:172-175.Crossref 17. Gill GN, Lazar CS. Increased phosphotyrosine content and inhibition of proliferation of EGF-α treated A431 cells . Nature . 1981;293:305-307.Crossref 18. Girai M, Gamou S, Minoshima S, Shimizu N. Two independent mechanisms for escaping epidermal growth factor mediated growth inhibition in epidermal growth factor receptor-hyperproducing human tumor cells . J Cell Biol . 1988;107:791-799.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

A Morphometric and Histologic Study of the Scalp in Psoriasis: Paradoxical Sebaceous Gland Atrophy and Decreased Hair Shaft Diameters Without Alopecia

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Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1989.01670170053007
Publisher site
See Article on Publisher Site

Abstract

Abstract • A histologic study was designed to evaluate the pilosebaceous unit of the scalp in nonpustular patch- and plaque-stage psoriasis. Punch biopsy specimens from involved and uninvolved areas of 28 patients were sectioned in a horizontal plane for qualitative and quantitative study. All samples were evaluated in a blind mode, and data were analyzed for statistical significance. There was no evidence for alopecia of any type. Sebaceous gland atrophy was a frequent concomitant in the psoriatic lesion, with probable down-sizing of the hair follicle and thinner hair shafts. Paradoxical sebaceous gland atrophy and down-sized hair follicles in psoriasis may be due to possible inhibiting effects of yet unidentified factors produced by the epidermal lesion. (Arch Dermatol. 1989;125:639-642) References 1. Shahrad P, Marks R. Hair follicle kinetics in psoriasis . Br J Dermatol . 1976;94:7-12.Crossref 2. Comaish S. Autoradiographic studies of hair growth in various dermatoses: investigation of a possible circadian rhythm in human hair growth . Br J Dermatol . 1969;81:282-283. 3. Katsuoka K, Schell H, Deinlein E, Hornstein OP. Cell kinetics in the human anagen hair follicle . Dermatologica . 1987;174:105-109.Crossref 4. Wyatt EH, Bottoms E, Comaish S. Abnormal hair shafts in psoriasis on scanning electron microscopy . Br J Dermatol . 1972; 87:368-373.Crossref 5. Wyatt EH, Roggott J. The influence of psoriasis on hair diameter . Br J Dermatol . 1981;105:349-350. 6. Headington JT. Transverse microscopic anatomy of the human scalp . Arch Dermatol . 1984;120:448-456.Crossref 7. Shuster S. Psoriatic alopecia . Br J Dermatol . 1972;87:73-77.Crossref 8. Braun-Falco O, Heilgemeir GP, Lincke-Plewig H. Histologische Differentialdiagnose von Psoriasis vulgaris and seborrhoischem Ekzem des Kapillitium . Hautarzt . 1979;30:478-483. 9. Braun-Falco O, Rassner B. Haarwurzelmuster bei Psoriasis vulgaris der Kopfhaut . Arch Klin Exp Dermatol . 1966;225:42-48.Crossref 10. Foreman MI, Picton W, Kukowiecki GA, Clark C. The effect of topical crude coal tar treatment on unstimulated hairless hamster skin . Br J Dermatol . 1979;100:707-715.Crossref 11. Altmeyer P. Ein Beitrag zur Histologie der von Kortikoidexterna verursachten Hautveränderungen . Hautarzt . 1977;28:83-88. 12. Nanney LB, Migid M, Stoscheck CM, King LE. Comparison of epidermal growth factor binding and receptor distribution in normal human epidermis and epidermal appendages . J Invest Dermatol . 1984;83:385-393.Crossref 13. Green MR, Couchman JR. Differences in human skin between the epidermal growth factor receptor distribution detected by EGF binding and monoclonal antibody recognition . J Invest Dermatol . 1985;85:239-245.Crossref 14. Nanney LB, Stoscheck CM, Magid M, King LE. Altered 125I-Epidermoid growth factor binding and receptor distribution in psoriasis . J Invest Dermatol . 1986;86:260-265.Crossref 15. Elder JT, Fisher GJ, Lindquist PB, et al. Overexpression of TGF-α, but not TGF-β, in psoriasis epidermis: potential role of phospholipase C . Science . 1989;243:811-814.Crossref 16. Moore GPM, Panaretto BA, Carter NB. Epidermal hyperplasia and wool follicle regression in sheep infused with epidermal growth factor . J Invest Dermatol . 1985;84:172-175.Crossref 17. Gill GN, Lazar CS. Increased phosphotyrosine content and inhibition of proliferation of EGF-α treated A431 cells . Nature . 1981;293:305-307.Crossref 18. Girai M, Gamou S, Minoshima S, Shimizu N. Two independent mechanisms for escaping epidermal growth factor mediated growth inhibition in epidermal growth factor receptor-hyperproducing human tumor cells . J Cell Biol . 1988;107:791-799.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: May 1, 1989

References