Abstract The guinea pig was found to be a useful experimental model for the study of otitis externa. Infection of the external ear canal could be induced by methods which would result in human disease. The clinical appearance of the diseased ear canal was similar to that in man. Prolonged exposure to water resulted in a shift from gram-positive normal bacterial flora to abnormal gram-negative flora and in disease. Data presented suggest that the presence of a normal bacterial flora is of significance in reducing the incidence of otitis externa. Removal of ear canal lipids did not result in disease, although this procedure predisposed the ear to infection following contamination. The data support the concept of a multiplex etiology for otitis externa. References 1. Jenkins BH: Treatment of otitis externa and swimmers ear . JAMA 175:402-404, 1961.Crossref 2. Cobet AB, Wright DN, Warren PI: Tektite-1 program: Bacteriological aspects . Aerospace Med 41:611-616, 1970. 3. McKelvie M, McKelvie P: Some aetiological factors in otitis externa . Brit J Derm 78:227-231, 1966.Crossref 4. Perry ET: The Human Ear Canal . Springfield, Ill, Charles C Thomas Publisher, 1957. 5. Grono LR: Experimental production of otitis externa in the dog . Vet Rec 85:34-36, 1969.Crossref 6. Senturia BH: Diseases of the External Ear . Springfield, Ill, Charles C Thomas Publisher, 1957. 7. Salvin SB, Lewis ML: External otitis with additional studies on the genus Pseudomonas . J Bact 51:495-506, 1946. 8. Carr CD, Sonnenwirth AC, Senturia BH: External otitis: Production of Pseudomonas areuginosa antibodies . Ann Otol 76:193-408, 1967. 9. Way SC, Memmesheimer A, Rowe AH: An evaluation of the etiology of otitis externa with additional studies . Arch Derm 72:138-140, 1955.Crossref 10. Punt NA: Otitis externa granulosa . Brit Med J 2:989-990, 1949.Crossref 11. Sataloff J, Zapp J: The environment in relation to otologic disease . Arch Environ Health 10:403-415, 1965.Crossref 12. Singer DE, Freeman E, Hoffert WR, et al: Otitis external: Bacteriological and mycological studies . Ann Otol 61:317-330, 1952. 13. Senturia BH, Carr CD: Studies of factors considered responsible for diseases of the external ear . Laryngoscope 68:2052-2079, 1950. 14. Wright DN: Water as an etiologic agent in human otitis externa. to be published.
Archives of Otolaryngology – American Medical Association
Published: Mar 1, 1972
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