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A Mendelian Randomization Approach for Assessing the Relationship Between Physical Activity and Depression

A Mendelian Randomization Approach for Assessing the Relationship Between Physical Activity and... Opinion EDITORIAL A Mendelian Randomization Approach for Assessing the Relationship Between Physical Activity and Depression Adam Mourad Chekroud, PhD There is a large and growing need to better manage the bur- gene variants can be used as instrumental variables, and be- cause these variants are allocated randomly before birth, they den of major depression. Antidepressants are not universally effective, and many patients undergo a trial-and-error pro- are relatively independent of environmental factors (which cess to find the right regimen. Psychological therapies are about mitigates the risk of residual confounding) and established be- equally effective and can be fore disease onset (which mitigates the risk of reverse causa- expensive and difficult to ac- tion). Put simply, if exercise causally reduces the incidence of Related article page 399 cess. Reducing the number of depression, then people who carry gene variants that increase individuals who develop depression would be ideal, but iden- exercise should proportionally be less likely to get depressed. tifying robust protective factors that are modifiable has proven Drawing on summary genetic data from approximately challenging. Physical exercise has emerged as a key opportu- 300 000 adults of European ancestry, Choi et al showed this nity. In large cross-sectional studies, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

A Mendelian Randomization Approach for Assessing the Relationship Between Physical Activity and Depression

JAMA Psychiatry , Volume 76 (4) – Apr 23, 2019

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Publisher
American Medical Association
Copyright
Copyright 2019 American Medical Association. All Rights Reserved.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/jamapsychiatry.2018.3870
Publisher site
See Article on Publisher Site

Abstract

Opinion EDITORIAL A Mendelian Randomization Approach for Assessing the Relationship Between Physical Activity and Depression Adam Mourad Chekroud, PhD There is a large and growing need to better manage the bur- gene variants can be used as instrumental variables, and be- cause these variants are allocated randomly before birth, they den of major depression. Antidepressants are not universally effective, and many patients undergo a trial-and-error pro- are relatively independent of environmental factors (which cess to find the right regimen. Psychological therapies are about mitigates the risk of residual confounding) and established be- equally effective and can be fore disease onset (which mitigates the risk of reverse causa- expensive and difficult to ac- tion). Put simply, if exercise causally reduces the incidence of Related article page 399 cess. Reducing the number of depression, then people who carry gene variants that increase individuals who develop depression would be ideal, but iden- exercise should proportionally be less likely to get depressed. tifying robust protective factors that are modifiable has proven Drawing on summary genetic data from approximately challenging. Physical exercise has emerged as a key opportu- 300 000 adults of European ancestry, Choi et al showed this nity. In large cross-sectional studies,

Journal

JAMA PsychiatryAmerican Medical Association

Published: Apr 23, 2019

References