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A Human Papillomavirus–Associated Disease With Disseminated Warts, Depressed Cell-Mediated Immunity, Primary Lymphedema, and Anogenital Dysplasia

A Human Papillomavirus–Associated Disease With Disseminated Warts, Depressed Cell-Mediated... OBSERVATION A Human Papillomavirus–Associated Disease With Disseminated Warts, Depressed Cell-Mediated Immunity, Primary Lymphedema, and Anogenital Dysplasia WILD Syndrome Alexander Kreuter, MD; Bettina Hochdorfer, MD; Norbert H. Brockmeyer, MD; Peter Altmeyer, MD; Herbert Pfister, PhD; Ulrike Wieland, MD; for the Competence Network HIV/AIDS Background: Epidermodysplasia verruciformis (EV) is the specimens from lesional biopsies carried-HPV. Con- a rare genodermatosis associated with infections with spe- sistently found -HPV types included HPV types 6, 51, cific human papillomaviruses (HPVs) belonging to the 52, 61, and 84 in the genitoanal region and HPV-57 in genus of HPV. Patients with EV usually have a selec- skin lesions. Histological and cytological evaluation re- tive defect in cell-mediated immunity. Although skin can- vealed multifocal anogenital dysplasia and benign geni- cer frequently develops in the sun-exposed cutaneous le- tal and cutaneous warts. sions of patients with EV, the anogenital area is usually not affected by squamous cell carcinomas related to mu- Conclusions: To our knowledge, only 1 other similar cosal HPV types. case of an EV-like syndrome with impaired, cell- mediated immunity and primary lymphedema has been Observations: We report the case of a patient with clini- described in the literature. Based on the characteristic clini- cal similarities http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Dermatology American Medical Association

A Human Papillomavirus–Associated Disease With Disseminated Warts, Depressed Cell-Mediated Immunity, Primary Lymphedema, and Anogenital Dysplasia

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Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6068
eISSN
2168-6084
DOI
10.1001/archderm.144.3.366
pmid
18347293
Publisher site
See Article on Publisher Site

Abstract

OBSERVATION A Human Papillomavirus–Associated Disease With Disseminated Warts, Depressed Cell-Mediated Immunity, Primary Lymphedema, and Anogenital Dysplasia WILD Syndrome Alexander Kreuter, MD; Bettina Hochdorfer, MD; Norbert H. Brockmeyer, MD; Peter Altmeyer, MD; Herbert Pfister, PhD; Ulrike Wieland, MD; for the Competence Network HIV/AIDS Background: Epidermodysplasia verruciformis (EV) is the specimens from lesional biopsies carried-HPV. Con- a rare genodermatosis associated with infections with spe- sistently found -HPV types included HPV types 6, 51, cific human papillomaviruses (HPVs) belonging to the 52, 61, and 84 in the genitoanal region and HPV-57 in genus of HPV. Patients with EV usually have a selec- skin lesions. Histological and cytological evaluation re- tive defect in cell-mediated immunity. Although skin can- vealed multifocal anogenital dysplasia and benign geni- cer frequently develops in the sun-exposed cutaneous le- tal and cutaneous warts. sions of patients with EV, the anogenital area is usually not affected by squamous cell carcinomas related to mu- Conclusions: To our knowledge, only 1 other similar cosal HPV types. case of an EV-like syndrome with impaired, cell- mediated immunity and primary lymphedema has been Observations: We report the case of a patient with clini- described in the literature. Based on the characteristic clini- cal similarities

Journal

JAMA DermatologyAmerican Medical Association

Published: Mar 1, 2008

References