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A Histological Study of the Evolution of Solar Urticaria

A Histological Study of the Evolution of Solar Urticaria Abstract † The histological evolution of solar simulator-induced lesions of solar urticaria was investigated in four severely affected white patients. A series of two to 32 minimal whealing doses of radiation, each much lower than the 24-hour minimal erythema dose, was administered to separate buttock sites. Biopsy specimens were obtained from the exposed areas at five minutes and two and 24 hours later, as well as from adjacent nonexposed skin. Lesions showed a statistically significant dose-dependent increase, predominantly perivascular, in upper dermal neutrophil and eosinophil numbers at five minutes and two hours, but not at 24 hours, and at higher radiation doses in mononuclear cell numbers by 24 hours. Nonirradiated patient skin and irradiated control subject skin was not similarly affected. These changes may be associated with the pathogenesis of solar urticaria. (Arch Dermatol 1988;124:80-83) References 1. Epstein JH: Photomedicine , in Smith K (ed): Science of Photobiology . New York, Plenum Press, 1977, pp 175-207. 2. Rantanen T, Suhonen R: Solar urticaria: A case with increased skin mast cells and good therapeutic response to an antihistamine . Acta Derm Venereol 1980;60:363-365. 3. Peters MS, Winkelmann RK: Neutrophilic urticaria . Br J Dermatol 1985;113:25-30.Crossref 4. Winkelmann RK, Black AK, Dover J, et al: Pressure urticaria: Histopathological study . Clin Exp Dermatol 1986;11:139-147.Crossref 5. Winkelmann RK: Cholinergic urticaria shows neutrophilic inflammation . Acta Derm Venereol 1985;65:432-434. 6. Winkelmann RK: Immunofluorescent and histologic study of cold urticaria . Arch Dermatol Res 1985;278:37-40.Crossref 7. Wong E, Morgan EW, MacDonald DM: The chloroacetate esterase reaction for mast cells in dermatopathology . Acta Derm Venereol 1982;62:431-434. 8. Hawk JLM, Eady RAJ, Challoner AVJ, et al: Elevated blood histamine levels and mast cell degranulation in solar urticaria . Br J Clin Pharmacol 1980;9:183-186.Crossref 9. Sams MW: Solar urticaria: Studies of the active serum factor . J Allergy Clin Immunol 1970;45:295-301. 10. Michell P, Hawk JLM, Shafrir A, et al: Assessing the treatment of solar urticaria, the dose response as a quantifying approach . Dermatologica 1980;160:198-207.Crossref 11. Murphy GM, Holden CAH, Young AR, et al: Quantitative histological studies of the evolution of the human sunburn reaction . Br J Dermatol 1986;113:771. 12. Wedmore CV, Williams TJ: Control of vascular permeability by polymorphonuclear leukocytes in inflammation . Nature 1981; 289:646-650.Crossref 13. Leiferman KM, Ackerman SJ, Sampson HA, et al: Dermal deposition of eosinophil-granule major basic protein in atopic dermatitis . N Engl J Med 1985;313:282-285.Crossref 14. Lewis DM, Lewis JC, Loegering PA, et al: Localization of the guinea pig eosinophil major basic protein to the core of the granule . J Cell Biol 1978;77:702-713.Crossref 15. Peters MS, Schroeter AI, Kephart GM, et al: Localization of eosinophil granule major basic protein in chronic urticaria . J Invest Dermatol 1983;81:39-43.Crossref 16. O'Donnell MC, Ackerman SJ, Gleich GJ, et al: Activation of basophil and mast cell histamine release by eosinophil granule major basic protein . J Exp Med 1983;157:1981-1991.Crossref 17. Zheutlin LM, Ackerman SJ, Gleich GJ, et al: Stimulation of basophil and rat mast cell histamine release by eosinophil granule-derived cationic proteins . J Immunol 1984;133:2180-2184. 18. Leiferman KM, Loegering PA, Gleich GJ: Production of wheal and flare skin reactions by eosinophil granule proteins . J Invest Dermatol 1984;82:414. 19. Paz RA, Spector WG: The mononuclear cell response to injury . J Pathol Bacteriol 1962;84:85-90.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

A Histological Study of the Evolution of Solar Urticaria

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Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1988.01670010044019
Publisher site
See Article on Publisher Site

Abstract

Abstract † The histological evolution of solar simulator-induced lesions of solar urticaria was investigated in four severely affected white patients. A series of two to 32 minimal whealing doses of radiation, each much lower than the 24-hour minimal erythema dose, was administered to separate buttock sites. Biopsy specimens were obtained from the exposed areas at five minutes and two and 24 hours later, as well as from adjacent nonexposed skin. Lesions showed a statistically significant dose-dependent increase, predominantly perivascular, in upper dermal neutrophil and eosinophil numbers at five minutes and two hours, but not at 24 hours, and at higher radiation doses in mononuclear cell numbers by 24 hours. Nonirradiated patient skin and irradiated control subject skin was not similarly affected. These changes may be associated with the pathogenesis of solar urticaria. (Arch Dermatol 1988;124:80-83) References 1. Epstein JH: Photomedicine , in Smith K (ed): Science of Photobiology . New York, Plenum Press, 1977, pp 175-207. 2. Rantanen T, Suhonen R: Solar urticaria: A case with increased skin mast cells and good therapeutic response to an antihistamine . Acta Derm Venereol 1980;60:363-365. 3. Peters MS, Winkelmann RK: Neutrophilic urticaria . Br J Dermatol 1985;113:25-30.Crossref 4. Winkelmann RK, Black AK, Dover J, et al: Pressure urticaria: Histopathological study . Clin Exp Dermatol 1986;11:139-147.Crossref 5. Winkelmann RK: Cholinergic urticaria shows neutrophilic inflammation . Acta Derm Venereol 1985;65:432-434. 6. Winkelmann RK: Immunofluorescent and histologic study of cold urticaria . Arch Dermatol Res 1985;278:37-40.Crossref 7. Wong E, Morgan EW, MacDonald DM: The chloroacetate esterase reaction for mast cells in dermatopathology . Acta Derm Venereol 1982;62:431-434. 8. Hawk JLM, Eady RAJ, Challoner AVJ, et al: Elevated blood histamine levels and mast cell degranulation in solar urticaria . Br J Clin Pharmacol 1980;9:183-186.Crossref 9. Sams MW: Solar urticaria: Studies of the active serum factor . J Allergy Clin Immunol 1970;45:295-301. 10. Michell P, Hawk JLM, Shafrir A, et al: Assessing the treatment of solar urticaria, the dose response as a quantifying approach . Dermatologica 1980;160:198-207.Crossref 11. Murphy GM, Holden CAH, Young AR, et al: Quantitative histological studies of the evolution of the human sunburn reaction . Br J Dermatol 1986;113:771. 12. Wedmore CV, Williams TJ: Control of vascular permeability by polymorphonuclear leukocytes in inflammation . Nature 1981; 289:646-650.Crossref 13. Leiferman KM, Ackerman SJ, Sampson HA, et al: Dermal deposition of eosinophil-granule major basic protein in atopic dermatitis . N Engl J Med 1985;313:282-285.Crossref 14. Lewis DM, Lewis JC, Loegering PA, et al: Localization of the guinea pig eosinophil major basic protein to the core of the granule . J Cell Biol 1978;77:702-713.Crossref 15. Peters MS, Schroeter AI, Kephart GM, et al: Localization of eosinophil granule major basic protein in chronic urticaria . J Invest Dermatol 1983;81:39-43.Crossref 16. O'Donnell MC, Ackerman SJ, Gleich GJ, et al: Activation of basophil and mast cell histamine release by eosinophil granule major basic protein . J Exp Med 1983;157:1981-1991.Crossref 17. Zheutlin LM, Ackerman SJ, Gleich GJ, et al: Stimulation of basophil and rat mast cell histamine release by eosinophil granule-derived cationic proteins . J Immunol 1984;133:2180-2184. 18. Leiferman KM, Loegering PA, Gleich GJ: Production of wheal and flare skin reactions by eosinophil granule proteins . J Invest Dermatol 1984;82:414. 19. Paz RA, Spector WG: The mononuclear cell response to injury . J Pathol Bacteriol 1962;84:85-90.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Jan 1, 1988

References