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A Histologic Comparison of Congenital and Acquired Nevomelanocytic Nevi

A Histologic Comparison of Congenital and Acquired Nevomelanocytic Nevi Abstract • A reliable microscopic differentiation of nevomelanocytic nevi (NMNs) as congenital or acquired would be useful in defining a histogenic relationship between cutaneous melanoma and congenital NMN. In order to delineate histologic differences between congenital NMN and acquired NMN, a standardized assessment was conducted blindly, using a sample of consecutive surgical specimens of NMN submitted to a children's hospital pathology file. Despite significant histologic differences between congenital NMN and acquired NMN, the lack of a reliable prevalence rate for the proportion of congenital NMNs among all NMN specimens submitted for pathologic examination precludes a precise estimate of predictive value for diagnosing a given NMN as congenital or acquired based on histologic features alone. The results of this study can be used neither to support nor to refute a histologic association between cutaneous melanoma and congenital NMN. (Arch Dermatol 1985;121:1266-1273) References 1. Lever WF, Schaumburg-Lever G: Histopathology of the Skin , ed 6. Philadelphia, JB Lippincott Co, 1983. 2. Nicholls EM: Development and elimination of pigmented moles, and the anatomical distribution of primary malignant melanoma . Cancer 1973;32:191-195.Crossref 3. Alper J, Holmes LB, Mihm MC: Birthmarks with serious medical significance: Nevocellular nevi, sebaceous nevi, and multiple cafe-au-lait spots . J Pediatr 1979;95:696-700.Crossref 4. Walton RG, Jacobs AH, Cox HJ: Pigmented lesions in newborn infants . Br J Dermatol 1976;95:389-396.Crossref 5. Rhodes AR: Pigmented birthmarks and precursor melanocytic lesions of cutaneous melanoma identifiable in childhood . Pediatr Clin North Am 1983;30:435-463. 6. Rhodes AR, Sober AJ, Day CL, et al: The malignant potential of small congenital nevocellular nevi . J Am Acad Dermatol 1982;6:230-241.Crossref 7. Mark GJ, Mihm MC, Liteplo MG, et al: Congenital melanocytic nevi of the small and garment type . Hum Pathol 1973;4:395-418.Crossref 8. Rhodes AR, Melski JW: Small congenital nevocellular nevi and the risk of cutaneous melanoma . J Pediatr 1982;100:219-224.Crossref 9. Rhodes AR, Melski JW, Sober AJ, et al: Increased intraepidermal melanocyte frequency and size in dysplastic melanocytic nevi and cutaneous melanoma . J Invest Dermatol 1983;80:452-459.Crossref 10. Rhodes AR, Harrist TJ, Momtaz-T K: The PUVA-induced pigmented macule . J Am Acad Dermatol 1983;9:47-58.Crossref 11. Wolff M: The pathology of cutaneous melanocytic lesions , in Ariel IM (ed): Malignant Melanoma . New York, Appleton-Century-Crofts, 1981, p 49. 12. Melski JW, Geer DE, Bleich HL: Medical information and storage retrieval using preprocessed variables . Comput Biomed Res 1978;11:613-621.Crossref 13. Zitelli JA, Grant MG, Abell E, et al: Histologic patterns of congenital nevocytic nevi and implications for treatment . J Am Acad Dermatol 1984;11:402-409.Crossref 14. Alper JC: Melanocytic nevi in neonates . J Am Acad Dermatol 1981;5:344.Crossref 15. Silvers DN, Helwig EB: Melanocytic nevi in neonates . J Am Acad Dermatol 1981;4:166-175.Crossref 16. Stenn KS, Arons M, Hurwitz S: Patterns of congenital nevocellular nevi . J Am Acad Dermatol 1983;9:388-393.Crossref 17. Reed WB, Becker SW Sr, Becker SW Jr, et al: Giant pigmented naevi, melanoma and leptomeningeal melanocytosis . Arch Dermatol 1965;91:100-119.Crossref 18. Ainsworth AM, Folberg R, Reed RJ, et al: Melanocytic nevi, melanocytomas, melanocytic dysplasias, and uncommon forms of melanoma , in Clark WH Jr, Goldman LI, Mastrangelo MJ (eds): Human Malignant Melanoma . New York, Grune & Stratton Inc, 1979, pp 167-208. 19. Blinova GA, Movchan VI: Comparative aspects of pigmented nevi in children, youths, and adults . Tumori 1978;64:285-294. 20. Lund HZ, Stobbe GD: The natural history of the pigmented nevus: Factors of age and anatomic location . Am J Pathol 1979;25:1117-1155. 21. Maize JC, Foster G: Age-related changes in melanocytic naevi . Clin Exp Dermatol 1979;4:49-58.Crossref 22. Stegmaier OC: Natural regression of the melanocytic nevus . J Invest Dermatol 1959;32:413-421.Crossref 23. Walton RG: Pigmented nevi . Pediatr Clin North Am 1971;18:897-923. 24. Vecchio TJ: Predictive value of a single diagnostic test in unselected populations . N Engl J Med 1966;274:1171-1173.Crossref 25. Pack GT, Lenson N, Gerber DM: Regional distribution of moles and melanomas . Arch Surg 1952;65:862-870.Crossref 26. Greene MH, Clark WH, Tucker MA, et al: Precursor nevi in cutaneous malignant melanoma: A proposed nomenclature . Lancet 1980;2:1024.Crossref 27. Rhodes AR, Harrist TJ, Day CL, et al: Dysplastic melanocytic nevi in histologic association with 234 primary cutaneous melanomas . J Am Acad Dermatol 1983;9:563-574.Crossref 28. Stegmaier OC, Montgomery H: Histopathologic studies of pigmented nevi in children . J Invest Dermatol 1953;20:51-64. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

A Histologic Comparison of Congenital and Acquired Nevomelanocytic Nevi

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Publisher
American Medical Association
Copyright
Copyright © 1985 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1985.01660100046013
Publisher site
See Article on Publisher Site

Abstract

Abstract • A reliable microscopic differentiation of nevomelanocytic nevi (NMNs) as congenital or acquired would be useful in defining a histogenic relationship between cutaneous melanoma and congenital NMN. In order to delineate histologic differences between congenital NMN and acquired NMN, a standardized assessment was conducted blindly, using a sample of consecutive surgical specimens of NMN submitted to a children's hospital pathology file. Despite significant histologic differences between congenital NMN and acquired NMN, the lack of a reliable prevalence rate for the proportion of congenital NMNs among all NMN specimens submitted for pathologic examination precludes a precise estimate of predictive value for diagnosing a given NMN as congenital or acquired based on histologic features alone. The results of this study can be used neither to support nor to refute a histologic association between cutaneous melanoma and congenital NMN. (Arch Dermatol 1985;121:1266-1273) References 1. Lever WF, Schaumburg-Lever G: Histopathology of the Skin , ed 6. Philadelphia, JB Lippincott Co, 1983. 2. Nicholls EM: Development and elimination of pigmented moles, and the anatomical distribution of primary malignant melanoma . Cancer 1973;32:191-195.Crossref 3. Alper J, Holmes LB, Mihm MC: Birthmarks with serious medical significance: Nevocellular nevi, sebaceous nevi, and multiple cafe-au-lait spots . J Pediatr 1979;95:696-700.Crossref 4. Walton RG, Jacobs AH, Cox HJ: Pigmented lesions in newborn infants . Br J Dermatol 1976;95:389-396.Crossref 5. Rhodes AR: Pigmented birthmarks and precursor melanocytic lesions of cutaneous melanoma identifiable in childhood . Pediatr Clin North Am 1983;30:435-463. 6. Rhodes AR, Sober AJ, Day CL, et al: The malignant potential of small congenital nevocellular nevi . J Am Acad Dermatol 1982;6:230-241.Crossref 7. Mark GJ, Mihm MC, Liteplo MG, et al: Congenital melanocytic nevi of the small and garment type . Hum Pathol 1973;4:395-418.Crossref 8. Rhodes AR, Melski JW: Small congenital nevocellular nevi and the risk of cutaneous melanoma . J Pediatr 1982;100:219-224.Crossref 9. Rhodes AR, Melski JW, Sober AJ, et al: Increased intraepidermal melanocyte frequency and size in dysplastic melanocytic nevi and cutaneous melanoma . J Invest Dermatol 1983;80:452-459.Crossref 10. Rhodes AR, Harrist TJ, Momtaz-T K: The PUVA-induced pigmented macule . J Am Acad Dermatol 1983;9:47-58.Crossref 11. Wolff M: The pathology of cutaneous melanocytic lesions , in Ariel IM (ed): Malignant Melanoma . New York, Appleton-Century-Crofts, 1981, p 49. 12. Melski JW, Geer DE, Bleich HL: Medical information and storage retrieval using preprocessed variables . Comput Biomed Res 1978;11:613-621.Crossref 13. Zitelli JA, Grant MG, Abell E, et al: Histologic patterns of congenital nevocytic nevi and implications for treatment . J Am Acad Dermatol 1984;11:402-409.Crossref 14. Alper JC: Melanocytic nevi in neonates . J Am Acad Dermatol 1981;5:344.Crossref 15. Silvers DN, Helwig EB: Melanocytic nevi in neonates . J Am Acad Dermatol 1981;4:166-175.Crossref 16. Stenn KS, Arons M, Hurwitz S: Patterns of congenital nevocellular nevi . J Am Acad Dermatol 1983;9:388-393.Crossref 17. Reed WB, Becker SW Sr, Becker SW Jr, et al: Giant pigmented naevi, melanoma and leptomeningeal melanocytosis . Arch Dermatol 1965;91:100-119.Crossref 18. Ainsworth AM, Folberg R, Reed RJ, et al: Melanocytic nevi, melanocytomas, melanocytic dysplasias, and uncommon forms of melanoma , in Clark WH Jr, Goldman LI, Mastrangelo MJ (eds): Human Malignant Melanoma . New York, Grune & Stratton Inc, 1979, pp 167-208. 19. Blinova GA, Movchan VI: Comparative aspects of pigmented nevi in children, youths, and adults . Tumori 1978;64:285-294. 20. Lund HZ, Stobbe GD: The natural history of the pigmented nevus: Factors of age and anatomic location . Am J Pathol 1979;25:1117-1155. 21. Maize JC, Foster G: Age-related changes in melanocytic naevi . Clin Exp Dermatol 1979;4:49-58.Crossref 22. Stegmaier OC: Natural regression of the melanocytic nevus . J Invest Dermatol 1959;32:413-421.Crossref 23. Walton RG: Pigmented nevi . Pediatr Clin North Am 1971;18:897-923. 24. Vecchio TJ: Predictive value of a single diagnostic test in unselected populations . N Engl J Med 1966;274:1171-1173.Crossref 25. Pack GT, Lenson N, Gerber DM: Regional distribution of moles and melanomas . Arch Surg 1952;65:862-870.Crossref 26. Greene MH, Clark WH, Tucker MA, et al: Precursor nevi in cutaneous malignant melanoma: A proposed nomenclature . Lancet 1980;2:1024.Crossref 27. Rhodes AR, Harrist TJ, Day CL, et al: Dysplastic melanocytic nevi in histologic association with 234 primary cutaneous melanomas . J Am Acad Dermatol 1983;9:563-574.Crossref 28. Stegmaier OC, Montgomery H: Histopathologic studies of pigmented nevi in children . J Invest Dermatol 1953;20:51-64.

Journal

Archives of DermatologyAmerican Medical Association

Published: Oct 1, 1985

References