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A FORM OF CHRONIC EPIDEMIC ENCEPHALITIS SIMULATING THE LANDOUZY-DEJERINE TYPE OF PROGRESSIVE MUSCULAR DYSTROPHY: Value of Studies on Creatine in Conjunction with Ingestion of Amino-Acid as an Aid in Differential Diagnosis

A FORM OF CHRONIC EPIDEMIC ENCEPHALITIS SIMULATING THE LANDOUZY-DEJERINE TYPE OF PROGRESSIVE... Abstract So protean are the manifestations of chronic epidemic encephalitis, that one's diagnostic acumen is frequently taxed to the utmost in attempting to determine the exact nature of the syndrome that presents itself. This is especially true in the not uncommon cases in which the encephalitic onset is obscure or so transitory as to have been overlooked altogether. Then again, it is possible that the disease has become distorted since the severe pandemics of 1917 to 1920. Grinker1 expressed the belief that it may not have an acute or subacute onset, the virus being so attenuated or the host so resistant that the disease process may be chronic from the beginning and run a progressive, slow, malignant course. The most frequent localization of the lesions of epidemic encephalitis is in the extrapyramidal motor system, and all are familiar with the striopallidal syndrome resembling paralysis agitans, which this produces. However, many References 1. Grinker, R. R.: Epidemic Encephalitis , in Neurology , Springfield, Ill., Charles C. Thomas, Publisher, 1934. 2. Stewart, W. B.: Epidemic Encephalitis , in Piersol, G. A.: Cyclopedia of Medicine , Philadelphia, F. A. Davis Company, 1932, vol. 5, pp. 105-120. 3. Ornsteen, A. M.: Syndrome of Amyotrophic Lateral Sclerosis in Epidemic Encephalitis , J. Nerv. & Ment. Dis. 72:369 ( (Oct.) ) 1930. 4. Electrical reactions are omitted. 5. Kuré, K., quoted by Grinker.1 6. Tripoli, C. J.; McCord, W. M., and Beard, H. H.: Muscular Dystrophy, Muscular Atrophy, Myasthenia Gravis and Strabismus: Clinical and Biochemical Studies of the Effects of Amino Acid Therapy , J. A. M. A. 103:1595 ( (Nov. 24) ) 1934. 7. Benedict, S. R., and Myers, V. C.: The Determination of Creatine and Creatinine , Am. J. Physiol. 18:397, 1907. 8. Folin, Otto: On the Determination of Creatinine and Creatine in Urine , J. Biol. Chem. 17:469, 1914. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

A FORM OF CHRONIC EPIDEMIC ENCEPHALITIS SIMULATING THE LANDOUZY-DEJERINE TYPE OF PROGRESSIVE MUSCULAR DYSTROPHY: Value of Studies on Creatine in Conjunction with Ingestion of Amino-Acid as an Aid in Differential Diagnosis

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Publisher
American Medical Association
Copyright
Copyright © 1937 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1937.02260230137008
Publisher site
See Article on Publisher Site

Abstract

Abstract So protean are the manifestations of chronic epidemic encephalitis, that one's diagnostic acumen is frequently taxed to the utmost in attempting to determine the exact nature of the syndrome that presents itself. This is especially true in the not uncommon cases in which the encephalitic onset is obscure or so transitory as to have been overlooked altogether. Then again, it is possible that the disease has become distorted since the severe pandemics of 1917 to 1920. Grinker1 expressed the belief that it may not have an acute or subacute onset, the virus being so attenuated or the host so resistant that the disease process may be chronic from the beginning and run a progressive, slow, malignant course. The most frequent localization of the lesions of epidemic encephalitis is in the extrapyramidal motor system, and all are familiar with the striopallidal syndrome resembling paralysis agitans, which this produces. However, many References 1. Grinker, R. R.: Epidemic Encephalitis , in Neurology , Springfield, Ill., Charles C. Thomas, Publisher, 1934. 2. Stewart, W. B.: Epidemic Encephalitis , in Piersol, G. A.: Cyclopedia of Medicine , Philadelphia, F. A. Davis Company, 1932, vol. 5, pp. 105-120. 3. Ornsteen, A. M.: Syndrome of Amyotrophic Lateral Sclerosis in Epidemic Encephalitis , J. Nerv. & Ment. Dis. 72:369 ( (Oct.) ) 1930. 4. Electrical reactions are omitted. 5. Kuré, K., quoted by Grinker.1 6. Tripoli, C. J.; McCord, W. M., and Beard, H. H.: Muscular Dystrophy, Muscular Atrophy, Myasthenia Gravis and Strabismus: Clinical and Biochemical Studies of the Effects of Amino Acid Therapy , J. A. M. A. 103:1595 ( (Nov. 24) ) 1934. 7. Benedict, S. R., and Myers, V. C.: The Determination of Creatine and Creatinine , Am. J. Physiol. 18:397, 1907. 8. Folin, Otto: On the Determination of Creatinine and Creatine in Urine , J. Biol. Chem. 17:469, 1914.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Nov 1, 1937

References