Abstract So protean are the manifestations of chronic epidemic encephalitis, that one's diagnostic acumen is frequently taxed to the utmost in attempting to determine the exact nature of the syndrome that presents itself. This is especially true in the not uncommon cases in which the encephalitic onset is obscure or so transitory as to have been overlooked altogether. Then again, it is possible that the disease has become distorted since the severe pandemics of 1917 to 1920. Grinker1 expressed the belief that it may not have an acute or subacute onset, the virus being so attenuated or the host so resistant that the disease process may be chronic from the beginning and run a progressive, slow, malignant course. The most frequent localization of the lesions of epidemic encephalitis is in the extrapyramidal motor system, and all are familiar with the striopallidal syndrome resembling paralysis agitans, which this produces. However, many References 1. Grinker, R. R.: Epidemic Encephalitis , in Neurology , Springfield, Ill., Charles C. Thomas, Publisher, 1934. 2. Stewart, W. B.: Epidemic Encephalitis , in Piersol, G. A.: Cyclopedia of Medicine , Philadelphia, F. A. Davis Company, 1932, vol. 5, pp. 105-120. 3. Ornsteen, A. M.: Syndrome of Amyotrophic Lateral Sclerosis in Epidemic Encephalitis , J. Nerv. & Ment. Dis. 72:369 ( (Oct.) ) 1930. 4. Electrical reactions are omitted. 5. Kuré, K., quoted by Grinker.1 6. Tripoli, C. J.; McCord, W. M., and Beard, H. H.: Muscular Dystrophy, Muscular Atrophy, Myasthenia Gravis and Strabismus: Clinical and Biochemical Studies of the Effects of Amino Acid Therapy , J. A. M. A. 103:1595 ( (Nov. 24) ) 1934. 7. Benedict, S. R., and Myers, V. C.: The Determination of Creatine and Creatinine , Am. J. Physiol. 18:397, 1907. 8. Folin, Otto: On the Determination of Creatinine and Creatine in Urine , J. Biol. Chem. 17:469, 1914.
Archives of Neurology & Psychiatry – American Medical Association
Published: Nov 1, 1937